Protein Alignment Khc and Kif27

DIOPT Version :9

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_780423.2
• Gene: Kif27 / 75050
• MGIID: 1922300
• Length: 1394
• Species: Mus musculus
• Alignment Length: 1141
• Identity: 297/1141 - (26%)
• Similarity: 499/1141 - (43%)
• Gaps: 294/1141 - (25%)

  Fly     6 EIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYN 70
            |||    |||..|.|||...|.....:..|:...|.::..|. ..:|:.||.||..|::|::|||
Mouse     3 EIP----IKVAVRIRPLLCKEVLHNHQVCVRDIPNTQQIIIG-RDRVFTFDFVFGKNSTQDEVYN 62

  Fly    71 EAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSV---KQGIIPRIVNDIFNHIYAMEVN 132
            ...|.:|..::.|||.|:||||||.||||:|:.|....||   ::|||||.:.:||..| :...:
Mouse    63 TCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGGHVASVVEGQKGIIPRAIQEIFQSI-SENPS 126

  Fly   133 LEFHIKVSYYEIYMDKIRDLLDV--SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKS 195
            ::|.|||||.|:|.:.:||||::  |..:|.:.||:.....:.||.|..|.|.|||..:::.|.:
Mouse   127 IDFKIKVSYIEVYKEDLRDLLELETSMKDLHIREDEKGNTVIVGAKECQVESVEDVMSLLQVGNA 191

  Fly   196 NRHIAVTNMNEHSSRSHSVFLINVKQ--------ENLE--NQKKLSGKLYLVDLAGSEKVSKTGA 250
            .||...|.|||||||||::|.|:|.|        ||.|  :.:.:..|.:.|||||||:|:|||.
Mouse   192 ARHTGTTQMNEHSSRSHAIFTISVCQVEKNAEAAENGEWYSHRHIVSKFHFVDLAGSERVTKTGN 256

  Fly   251 EGTVLDEAKNINKSLSALGNVISALADGNK--THIPYRDSKLTRILQESLGGNARTTIVICCSPA 313
            .|....|:..||..|.|||||||||.|..:  :||||||:|:||:|::||||:|:|.::.|.||:
Mouse   257 TGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRLLKDSLGGSAKTVMITCVSPS 321

  Fly   314 SFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRA 378
            |.:..|:.::|.:..||:.::|...:|....|:                  :::::|.|:...|
Mouse   322 SSDFDESLNSLKYANRARNIRNKPALNISPQAD------------------RMDEMEFEIKLLR- 367

  Fly   379 GETVKAEEQINMEDLMEASTPN---------LEVEAAQTAAAEAALAAQRTALANMSASVAVNEQ 434
             |.::: .|.::....:||:.|         ||.:.||  ..|..|..|.......:..|.:.:.
Mouse   368 -EALQS-HQASISQASQASSENVPDQNRIHSLEEQVAQ--LQEECLGYQDCIEQAFAFLVDLKDA 428

  Fly   435 ARLATECERLYQQLDDKDEEI----------NQ---------QSQYAEQLKEQ------------ 468
            .:|..:.:...|:...:.:|:          ||         |.....|||.:
Mouse   429 VKLNQKQQHKLQEWFSRTQEVRKAVLTPLPGNQGIGNLEEGPQHLTVLQLKRELKKYQCALAADQ 493

  Fly   469 -VMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVL-------QALEELAVNYDQKSQEI 525
             |..|::|      |.|.|::::..:.||::.....:||..       :.:.|..:..||.|.|:
Mouse   494 VVFTQKDL------ELEELRTQVQLMMQESKGHAVSLKEAQKVNRLQNEKIIEQQLLVDQLSAEL 552

  Fly   526 DNKNKDI------------DALNEELQQKQSVFNA------------------ASTELQQLKDMS 560
            ..::..:            ||...|.:...:.|.:                  :||.:..|..:.
Mouse   553 AKRSLSVPTSAKESCGDGPDARASEKRPHTAPFESHWGHYVYIPSRQDFKKVCSSTPVYSLDQVF 617

  Fly   561 SHQKKRITEMLTNLLRDLGEV---------------GQ------------AIAPGE--------- 589
            :..:.| ::||...|.|..||               ||            |..||.
Mouse   618 AGFRTR-SQMLMGHLEDQDEVLHCQFSDNSDDEDSEGQEKPRVRSRSHSWAKKPGSVCSLVELSD 681

  Fly   590 ----------SSIDLKMSALAGTDASKVEEDFTMARLFISKMK---------------------- 622
                      .:.||||.:|..:....::: ...:.|.::|.|
Mouse   682 TQAESQRSYLGNGDLKMESLQESQEINLQK-LRTSELILNKAKQKMRELTINIRMKEDLIKELIK 745

  Fly   623 --TEAKNIAQRCS------NMETQQA-----DSNKKISEYE-KDLGEYRLLIS-QHEARMKSLQE 672
              ..||:::::.|      ..|.:||     ::.|::.|.| |||.:..|.:. |.|.|.|
Mouse   746 TGNNAKSVSRQYSLKVTKLEHEAEQAKVELTETRKQLQELESKDLSDVALKVKLQKEFRKK---- 806

  Fly   673 SMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQV 737
             |..|:.:.:.|::          |.:.::.:::::.:.::||.||    :..:|.|:....:..
Mouse   807 -MDAAKMRVQVLQK----------KQQDSKKLASLSIQNEKRASEL----EHNVDHLKYQKVQLQ 856

  Fly   738 SELRDEIAAKQHEMD-EMKDVHQKL----LLAHQ-----------------------QMTADYEK 774
            ..||:| ..|:.::| |:|...||:    |.|.|                       :....::|
Mouse   857 RRLREE-GEKKKQLDAEIKRDQQKIKELQLKAGQGEGLNPKAEDQDGFNLNRRKSPFRSGDQFQK 920

  Fly   775 VRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAK-----------ELQTLHNLRKLFVQDL 828
            :.::......|::.::...:..|...:|||..|..|:|           |.:.|.:.:.|....|
Mouse   921 LDEQRKWLDEEVEKVLSQRQELEMLEEDLKKREAIVSKKEALLQEKSLLENKKLRSSQALSTDGL 985

  Fly   829 QQRIRKNVVNEESEE-----DGGSLAQKQKIS----FLENNLDQLTKVHKQLVRDNADLRCE--- 881
            :...|.|::::|..|     :.....:|.|||    .|:...|||     |..|::.|.|.:
Mouse   986 KISARLNLLDQELSEKSLQLESSPTEEKMKISEQVQALQRERDQL-----QRQRNSVDERLKHGR 1045

  Fly   882 --LPKLEKRLRCTMERVKALETALKEAKEGAMRDRK 915
              .||.|..|....|.::|||.|: |.|..:::.|:
Mouse  1046 VLSPKEEHLLFQLEEGIEALEAAI-EFKNESIQSRQ 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	144/339 (42%)
		KISc	12..340	CDD:214526	145/344 (42%)
		Apolipoprotein	595..744	CDD:279749	35/185 (19%)
Kif27	NP_780423.2	KISc_KIF4	4..342	CDD:276823	146/343 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..582		3/22 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..665		2/22 (9%)
		Smc	721..>1096	CDD:224117	82/386 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..916		2/29 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1267..1319
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1325..1344

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910