Protein Alignment Khc and Stard9

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: XP_036018388.1
• Gene: Stard9 / 668880
• MGIID: 3045258
• Length: 4598
• Species: Mus musculus
• Alignment Length: 1017
• Identity: 244/1017 - (23%)
• Similarity: 397/1017 - (39%)
• Gaps: 313/1017 - (30%)

  Fly    12 SIKVVCRFRPLNDSEEKAGSKFVVKFPNNV-----------EENCISIAGKV--YLFDKVF---- 59
            :::|..|.|||:..|.|.|.:.:|:..:.|           .|:......||  :.||..:
Mouse     3 NVQVAVRVRPLSKRETKEGGRIIVEVDDKVAKIRNVKVDSRPESFGDTREKVVAFGFDYCYWSVN 67

  Fly    60 --KPN-ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVND 121
              .|: ||||.|:.:....:::....|||..:||||||.||||:||   :|.....|:.|||...
Mouse    68 PEDPHYASQEVVFRDLGTEVLSGAAKGYNICLFAYGQTGSGKTYTM---LGTPASVGLTPRICEG 129

  Fly   122 IF-NHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVN----LSVHEDKNRVPYVKGATERFVS 181
            :| .............||||:.|||.:::||||..|..|    |.|.|.....|||:|.::..|:
Mouse   130 LFIREDDCASQPCSRSIKVSFLEIYNERVRDLLKQSNQNKSYTLRVREHPEMGPYVQGLSQHVVT 194

  Fly   182 SPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQ--KKLSGKLYLVDLAGSEK 244
            :.:.|.:::|.|.:||..|.|:::|.|||||::|.|:..|..|:|.  .:.:.|:.||||||||:
Mouse   195 NYQQVIQLLEAGIANRITAATHVHEASSRSHAIFTIHCTQAILQNNLPSETASKINLVDLAGSER 259

  Fly   245 VSKTGAEGTVLDEAKNINKSLSALGNVISALADGN------------------------------ 279
            ...:..:..: .|..||||||..||.|||.||..:
Mouse   260 ADPSYCKDRI-TEGANINKSLVTLGIVISTLAQNSQVFSSCQSLSSAASSGGDSGVPSTTSGASS 323

  Fly   280 -------KTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVV 337
                   :::||||||.||.:|:||||||::|.:|...|||..:.|||.||:.:...||.:.|..
Mouse   324 GGGPARRQSYIPYRDSVLTWLLKESLGGNSKTIMVATVSPAHTSYSETMSTMRYASNAKNIINKP 388

  Fly   338 CVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLE 402
            .|||               :.|.:|   :.:|..|:.|.:|       ..:|.|
Mouse   389 RVNE---------------DANVKL---IRELREEIERLKA-------VLLNFE----------- 417

  Fly   403 VEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKE 467
                               |.|.|   ::|:.  |....:.|..|.|.|.:.:.|........::
Mouse   418 -------------------LRNFS---SLNDD--LDESLQELVFQSDLKIDTLTQHWTEKRNDRQ 458

  Fly   468 QVMEQEELIANARREYETLQSEMARIQQ-ENESAKEEVKEVLQALEELAVNYDQKSQEID-NKNK 530
            .:||...:..|.:|....:.|.:..:.. |::.....|  ||..|:|...    |...|| ::.:
Mouse   459 ALMEHYGVDINRKRARVVIDSSLPHLMALEDDVLSTGV--VLYHLKEGTT----KIGRIDSDQEQ 517

  Fly   531 DIDALNEELQQKQSVFNA-----------------------ASTELQQLKDMSSHQKKRITEMLT 572
            ||....:.:::......:                       ||..|.|.:|...:....:|..:.
Mouse   518 DIVLQGQWIERDHCTITSTCGVVILRPTQGARCTVNGREVTASCRLTQGRDYGLNSGWCVTGAVI 582

  Fly   573 NLLRDLGEVGQAIA-----PGESSI----DLKMSALAGTDAS----KVEEDFTMARLFISK-MKT 623
            .|       |:|..     |.|:::    .||:....|:..|    .::.|.:.:||.:.. ::.
Mouse   583 TL-------GKAQKFRFNHPAEAAVLRHQRLKVGEALGSSGSLEWLDLDGDVSASRLGLCPVLRK 640

  Fly   624 EAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQI 688
            |.:.:.::|                 ::|                  |:..|.:|...|...||
Mouse   641 ERRVLEEQC-----------------DRD------------------QQPSRHSEIPYRAQPEQ- 669

  Fly   689 DSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDE 753
                ::|       ||.|:    ||:|:|.:|....:: ||...|..|                :
Mouse   670 ----QQC-------HVEAL----KQQAKEGQSRVQKEL-ELDHTHISQ----------------Q 702

  Fly   754 MKDVHQKLLLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKE--LQT 816
            :|| :|:.||..:...|...:.:||..           ..|.:|        ||.:||.:  |.|
Mouse   703 IKD-NQQWLLTEETWLASLRETQQEGN-----------CGEEKE--------LEASVAPDAWLPT 747

  Fly   817 LHNLRKLFVQDLQQRI-----------RKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQ 870
            :.......:...|:|:           |..|.|          .:::|:||      ||.::.|
Mouse   748 VPQTPPSPLVQSQKRVVQPQCSPRHTTRATVWN----------IRQKKVSF------QLERIIK- 795

  Fly   871 LVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMR 912
                           ::||.....|::.|.|......:||.|
Mouse   796 ---------------KRRLLEAQRRLEQLSTFFWIQDDGASR 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	131/384 (34%)
		Smc	<341..>807	CDD:440809	85/504 (17%)
		Khc_CBD_cc	856..925	CDD:467880	12/57 (21%)
Stard9	XP_036018388.1	KISc_KIF1A_KIF1B	2..391	CDD:276816	132/391 (34%)
		Kinesin_assoc	390..504	CDD:465047	31/175 (18%)
		FHA	475..605	CDD:469597	23/142 (16%)
		SRPBCC	4394..4598	CDD:472699