Protein Alignment Khc and KIF15

DIOPT Version :9

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 1125
• Identity: 292/1125 - (25%)
• Similarity: 494/1125 - (43%)
• Gaps: 276/1125 - (24%)

  Fly    11 DSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEEN-CISIAG------------KVYLFDKVFKPN 62
            |:|||..|.||   ..|::||.       :.|:| |:|:..            |.:.||.|...:
Human    25 DAIKVFVRIRP---PAERSGSA-------DGEQNLCLSVLSSTSLRLHSNPEPKTFTFDHVADVD 79

  Fly    63 ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVI-GDSVK---QGIIPRIVNDIF 123
            .:||.|:...|||||...::||||||||||||.||||.||.|.. .|:..   :|:|||....:|
Human    80 TTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLRGVIPRSFEYLF 144

  Fly   124 NHIYAME----VNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPE 184
            :.|...:    ....|..|.|:.|||.::|.||||.:...|.:.|...:..:|.||.|:.|:|..
Human   145 SLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLLDSASAGLYLREHIKKGVFVVGAVEQVVTSAA 209

  Fly   185 DVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKL----SGKLYLVDLAGSEKV 245
            :.::|:..|..||.:|.|:||..|||||:||.|.:  |::|...::    :..|.||||||||:.
Human   210 EAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITI--ESMEKSNEIVNIRTSLLNLVDLAGSERQ 272

  Fly   246 SKTGAEGTVLDEAKNINKSLSALGNVISALAD---GNKTHIPYRDSKLTRILQESLGGNARTTIV 307
            ..|.|||..|.||.|||:|||.||.||:||.|   |.:.|:.|||||||.:|::||||||:|.|:
Human   273 KDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCYRDSKLTFLLRDSLGGNAKTAII 337

  Fly   308 ICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIE 372
            ....|.|....||.|||:|.:|||.:||...|||:.....            ::|:.:|::|:.:
Human   338 ANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNEDTQGNV------------SQLQAEVKRLKEQ 390

  Fly   373 LARWRAGET------VKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAV 431
            ||...:|:|      .:.:::.|..:..:                ||.|..:::.....|....|
Human   391 LAELASGQTPPESFLTRDKKKTNYMEYFQ----------------EAMLFFKKSEQEKKSLIEKV 439

  Fly   432 NEQARLATECERLYQQLD-----DKDEEINQQSQYAEQ----LKEQVMEQEELIANARREYETLQ 487
            .:...|..:.|:..|...     .:|:.|..:..:.|.    |.|   ||:.|::..|.|.:||:
Human   440 TQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFLPE---EQDRLLSELRNEIQTLR 501

  Fly   488 SE------MARIQQENESAKEEVKEVLQALEELAVNYDQKSQEID-------------------- 526
            .:      :|:...||.|.:||.:. |:.||.:     :::||:|
Human   502 EQIEHHPRVAKYAMENHSLREENRR-LRLLEPV-----KRAQEMDAQTIAKLEKAFSEISGMEKS 560

  Fly   527 NKNK---------------DIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLR 576
            :||:               :.:.|..:|.|.|:..|.:..|.::.|:::   :||..|:.:.|
Human   561 DKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEYEEFKELT---RKRQLELESEL-- 620

  Fly   577 DLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKN---IAQRCSNME-- 636
                  |::.....:::   :.|..|.|.|.:|...:.::....:|  .||   |.....|:|
Human   621 ------QSLQKANLNLE---NLLEATKACKRQEVSQLNKIHAETLK--LKNVMWIYNDLFNLENA 674

  Fly   637 -------------TQQADSNKKISEYEKDLGEYRLLISQH------------------------- 663
                         ..|..| :.:.:...::|.:..|.:|:
Human   675 GFFPIQIITTPTKAYQLHS-RPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEMNEQAFEAI 738

  Fly   664 -------EARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSM 721
                   :.:|.:||..:.|.|:|...|::.:|.|.....:::  |..|:...:..::.|||.|.
Human   739 SEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQ--ELFSSERIDWTKQQEELLSQ 801

  Fly   722 FDSQMDELREAHTR------QVSELR-------DEIAA-----------KQHEMDEMKDVHQKLL 762
            .:....:|:|..|:      :|.:||       .|:::           ::.|.:::.:.|..:.
Human   802 LNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQ 866

  Fly   763 LAHQQMTADYEKVRQEDA------------------EKSSELQNIILTNERREQARKDLKGLEDT 809
            |....:..:.||:.:..|                  :.|..|||.   .:..|..:.||..|.:.
Human   867 LQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLSRNLQNF---KKENETLKSDLNNLMEL 928

  Fly   810 VAKELQTLHNLRKLFVQDLQQ------RIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVH 868
            :..|.:..:.|...|.:|.:.      ::.:.|..|:.:|......|..|:..||.:|....||.
Human   929 LEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEKVI 993

  Fly   869 KQL--VRDN-----ADLRCELPKLEKRLRCTMERVKALETALKEAKE------GAMRDR------ 914
            ..|  .||:     |||..::.:|...: |  |:.:.::|..:|.|:      .|:.||
Human   994 SSLEKSRDSDKKVVADLMNQIQELRTSV-C--EKTETIDTLKQELKDINCKYNSALVDREESRVL 1055

  Fly   915 -KRYQYEVDRIKEAVRQKHL 933
             |:.:.::..:||.:|.:.|
Human  1056 IKKQEVDILDLKETLRLRIL 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	147/349 (42%)
		KISc	12..340	CDD:214526	148/355 (42%)
		Apolipoprotein	595..744	CDD:279749	37/211 (18%)
KIF15	XP_016862373.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910