DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and kif3a

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	719	Identity:	226/719 - (31%)
Similarity:	354/719 - (49%)	Gaps:	94/719 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EIPAEDSIKVVCRFRPLNDSEEKAGSK---FVVKFPNNVEENCISIAG---KVYLFDKVFKPNAS 64
            ::...|::|||.|.||||:.|:..|.|   .|.:....:..|.:.|:.   |.:.||.||.|::.
Zfish    11 KLEVSDNVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVNKLDISSEPPKTFTFDTVFGPDSK 75

  Fly    65 QEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAM 129
            |..|||..|:.|:..||.||||||||||||.:|||.|||||......:||||.....:|.||...
Zfish    76 QLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHVFGHIAKA 140

  Fly   130 EVNLEFHIKVSYYEIYMDKIRDLLDVSKV-NLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEG 193
            |.:..|.::|||.|||.:::||||...:: .|.|.|..:...|:|..:...|::.:|:..::..|
Zfish   141 EGDTRFLVRVSYLEIYNEEVRDLLGKDQMQRLEVKERPDVGVYIKDLSGYVVNNADDMDRIMTLG 205

  Fly   194 KSNRHIAVTNMNEHSSRSHSVFLINVK--QENLE-NQKKLSGKLYLVDLAGSEKVSKTGAEGTVL 255
            ..||.:..|||||||||||::|.|.::  ::.:: ||....|||:||||||||:..||||.|..|
Zfish   206 HKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNQHVRMGKLHLVDLAGSERQGKTGATGQRL 270

  Fly   256 DEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESET 320
            .||..||.|||.||||||||.||..||:|||:|||||:||:|||||::|.:.....||.:|..||
Zfish   271 KEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDET 335

  Fly   321 KSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAE 385
            .|||.:..|||.:||...:||: ..:...|:::||.|:   ||.|:|:          ||.:...
Zfish   336 ISTLRYANRAKNIKNKARINED-PKDALLRQFQKEIEE---LKKKLEE----------GEEISGS 386

  Fly   386 EQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDD 450
            :....:|:.|           ...........:|.....:|....|..||::..|.:.|..:||.
Zfish   387 DGSGSDDMDE-----------DDVGDGGERRRKRRGRKKVSPDKMVEMQAKIEEERKALEAKLDM 440

  Fly   451 KDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVK---------- 505
            ::||.|:                     ||.|.|..:.::.:.|||:....|::.
Zfish   441 EEEERNK---------------------ARAELEKREKDLLKAQQEHHLLLEKLSALEKRVIVGG 484

  Fly   506 -EVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITE 569
             ::|...||.....::.:.|::.:.|..:.|..||::|:........:...|::.:..:.|::.:
Zfish   485 VDLLAKAEEQEKLLEESNNELEERRKRAEQLRRELEEKEQERLDIEEKYTSLQEEAQGKTKKLKK 549

  Fly   570 MLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKM------------- 621
            :.|.|:....|:..........|:..:.     :..::..:..:..|.|...
Zfish   550 VWTMLMAAKSEMADLQQEHHREIEGLLE-----NIRQLSRELRLQMLIIDNFIPQEYQEMIENYV 609

  Fly   622 -------KTEAKNIAQRCSNMETQQADSNKKISE-YEKDLGEYRLLISQHEARMKSLQ-ESMREA 677
                   :.:.|.:|...:||..|...|:||..: :|.||....|..::...|...:: |..|.:
Zfish   610 HWNEDIGEWQLKCVAYTGNNMRKQTPVSDKKEKDPFEVDLSHVYLAYTEESMRQSLMKLERPRTS 674

  Fly   678 ENKK 681
            :|.|
Zfish   675 KNGK 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	156/332 (47%)
		KISc	12..340	CDD:214526	157/337 (47%)
		Apolipoprotein	595..744	CDD:279749	19/109 (17%)
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	156/331 (47%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	152/324 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910