Protein Alignment Khc and cmet

DIOPT Version :9

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1249
• Identity: 302/1249 - (24%)
• Similarity: 502/1249 - (40%)
• Gaps: 379/1249 - (30%)

  Fly     1 MSAEREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIA---GKVYLFDKVFKPN 62
            |||:.    ..||:|..:.||   .|....|.:.||     |...|.:|   .:.|:||.||...
  Fly     1 MSAKN----ASSIQVCIKVRP---CEPGLTSLWQVK-----ERRSIHLADSHAEPYVFDYVFDEG 53

  Fly    63 ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIY 127
            ||.::|::..||.||...:.|:|||||||||||||||:||   :||....|::.....:||..|
  Fly    54 ASNQEVFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM---MGDEQNPGVMVLAAKEIFQQI- 114

  Fly   128 AMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEE 192
            :.|...:|.::|.|.|||.:||.|||:....:|.:||..|.:..| ...|..::|..|:..::..
  Fly   115 SSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNV-NCEECIITSEVDLLRLLCL 178

  Fly   193 GKSNRHIAVTNMNEHSSRSHSVFLINV---KQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTV 254
            |...|.:..|||||.|||||::|.|.:   |.::.::...:...|.||||||||:..:|||.|..
  Fly   179 GNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARGAR 243

  Fly   255 LDEAKNINKSLSALGNVISAL---ADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFN 316
            |.|..:|||||..|.|||.:|   ||...|:  |||||||||||.||||||.|:|:....|:...
  Fly   244 LKEGGHINKSLLFLSNVIKSLSENADNRFTN--YRDSKLTRILQASLGGNAFTSIICTIKPSIME 306

  Fly   317 ESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEK----------EKEKNARLKGKVEKLEI 371
            ||:  |||.|..|||.::....|||.::.....:|.|:          |:|:....:.|||.||.
  Fly   307 ESQ--STLSFATRAKKIRIKPQVNEMVSDATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLER 369

  Fly   372 ELA----RWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAAL----------------- 415
            ::.    :...|.::..:.|.........:.....:|.|:|...|..:
  Fly   370 QIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRIDQFPKVSHLPKPVFFHT 434

  Fly   416 --AAQR----TALANMSASVAVNEQAR------LATEC--------------------------- 441
              |.:|    ....|:..|:.:..::.      |..||
  Fly   435 SNAGKRWDNIPKTINILGSLDIGTESNSISEEFLPAECIDFGSPRPDVLKPMLTIRQLPDLPLTP 499

  Fly   442 ------ERLYQQLDD------KDEEINQQSQYAEQLKEQV---------MEQEELIANARREYET 485
                  :::.:::.|      .::....:.:..:.|||::         :|||.|....|  |:.
  Fly   500 KGPLTTDKIKKEIQDLQMFTSLEKHFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKER--YDA 562

  Fly   486 LQSEMARIQQENESAKEEVKEV------------------------------------------- 507
            |:.|:..::.:||:|..::.|:
  Fly   563 LEKEVTSLRADNEAANSKISELEEKLSTLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLL 627

  Fly   508 ---------------------------------------------------LQALEELAVNYDQK 521
                                                               .:.||:|..:.:.|
  Fly   628 SALLEKESTIESLQKSLDNLTRDVLRNSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESK 692

  Fly   522 --SQEIDNKNKDIDALNEELQQKQSVFNAASTE-LQQLKDMSSHQKKRITEMLTNLLRDLGEVGQ 583
              |.|.|....:|.::.::|:..:|.||.||:| :|:..|.     :|:::.|:......|::.:
  Fly   693 KNSCECDQLRLEIVSVRDKLESVESAFNLASSEIIQKATDC-----ERLSKELSTSQNAFGQLQE 752

  Fly   584 AIAPGESSIDLKMSA-LAGTDA-----SKVEEDFTMARLFISKMKTEAKNIA----QRCSNMETQ 638
            ..    .::|.:..| .||...     ..|:|.:...:....::::.|::.:    ||..|..|:
  Fly   753 RY----DALDQQWQAQQAGITTLHEKHEHVQEKYQKLQEEYEQLESRARSASSAEFQRLQNDNTK 813

  Fly   639 -QAD---SNKKISEYEKDLGEY--------RLLISQHE--ARMKSLQESMREAENKKRTLEEQI- 688
             |||   .|:::.|.:..|.|.        :|.|..||  |::|.|:.:..|.:.:...|..|:
  Fly   814 FQADIASLNERLEEAQNMLTEVQNSESTVEKLRIQNHELTAKIKELETNFEEMQREYDCLSNQLM 878

  Fly   689 ------DSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHT-RQVSELRDEIAA 746
                  |:|||| .|.:...||     ||..|:..:.|.||.|..::...|. .|:||...:|..
  Fly   879 ESVQENDALREE-IKQRPTSHV-----EESMRSSGISSDFDEQKQDINLLHQFVQLSESVQQIEL 937

  Fly   747 KQH-------EMDEMK----DVHQKLLLAHQQMTADY--EKVRQEDA------------------ 780
            :.|       ..::||    :...||.|.    :|:|  |..||.||
  Fly   938 QHHSGISRLFRANQMKLDQSEPGLKLCLE----SAEYIEEDNRQSDATEPICLKGFLKRHRFQIK 998

  Fly   781 ---------------------------EKSSELQNIILT-NERREQARKDLKGLEDTVAKE---- 813
                                       |||:.::....| ||.|||    :..||..:.::
  Fly   999 RLSQEHVDMGEEKRLLDIISQLEQEIEEKSALMEATEATINEMREQ----MTNLESALLEKSVII 1059

  Fly   814 ------LQTLHNLRK------LFVQDLQQRIRKNVVNEES------EED------GGSLAQKQKI 854
                  .:.:.:|.|      :..::||.|:.:.....||      :||      .....::|::
  Fly  1060 NKVEDYQRQIESLEKQNAEMTMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEV 1124

  Fly   855 SFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAM-------- 911
            :.|:.:   :|::..|:    :||:.||....::::.....:..|:|..:|..|..:
  Fly  1125 ATLKTS---ITELQSQV----SDLKAELENHLRQIQLKDGNIARLQTDFEEMSERCLSMEVRLAE 1182

  Fly   912 --RDRKRYQYEVDR 923
              .|.|:.|..:||
  Fly  1183 LDEDTKQKQELLDR 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	140/331 (42%)
		KISc	12..340	CDD:214526	140/336 (42%)
		Apolipoprotein	595..744	CDD:279749	46/180 (26%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	140/336 (42%)
		Motor_domain	8..321	CDD:277568	140/329 (43%)
		Smc	<680..1449	CDD:224117	118/547 (22%)
		TMPIT	779..>867	CDD:285135	21/87 (24%)
		Smc	1042..1910	CDD:224117	31/166 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840