DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and Klp98A

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	1110	Identity:	271/1110 - (24%)
Similarity:	445/1110 - (40%)	Gaps:	308/1110 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEE------NCISIAGK-----------VYLFDKVF 59
            |:||..|.||.|..|....::.:::..|....      ..|..||:           .:.||...
  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67

  Fly    60 KPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFN 124
            ...|:||:||::....:|.....|||..:||||||.||||.||   :|.....|:||||..::|.
  Fly    68 PHFATQEQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTM---MGTPNNPGLIPRICEELFA 129

  Fly   125 HI-YAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKV--NLSVHEDKNRVPYVKGATERFVSSPEDV 186
            .: ...|....:....||.|||.::::|||.....  .|.|.|.::..|||:..::..||..:::
  Fly   130 RMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLRVREHRSLGPYVENLSQHAVSDFDEI 194

  Fly   187 FEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQ--KKLSGKLYLVDLAGSEKVSKTG 249
            .|.|..|.:.|..|.||||:.|||||::|.|...|....|.  .:...|::||||||||:.:.||
  Fly   195 QECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETVSKIHLVDLAGSERANATG 259

  Fly   250 AEGTVLDEAKNINKSLSALGNVISALAD----GNKT-----------------HIPYRDSKLTRI 293
            |.|..|.|..:|||||..||:||||||:    |:.:                 :||||||.||.:
  Fly   260 ATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPYRDSILTWL 324

  Fly   294 LQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEK 358
            |::|||||::|.::...|||..|.|||.|||.:..|||.:.|...|||:...:..:...|:..:.
  Fly   325 LKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRELREEINKL 389

  Fly   359 NARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALA 423
            .:.|.|.:..|:                            |:|:|                  ||
  Fly   390 KSMLAGDIHSLQ----------------------------PSLKV------------------LA 408

  Fly   424 NMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQS 488
            ::....|   |.::.|             ||..::.:.|:.:   :.||:.|..........|.|
  Fly   409 DLQKKEA---QEKVLT-------------EEWTEKWKVAQSI---LQEQKSLGLRKSGVGVVLDS 454

  Fly   489 EMARIQQENESAKEEVKEVLQALEELAVNYDQK----SQEIDNKNKDIDALNEELQQKQSVFNAA 549
            ||..:...:......|  .|.:|:|.......:    :|:|:.....|.|.:..:..|..|....
  Fly   455 EMPHLIGIHNDVTTGV--TLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLKGGVVTLH 517

  Fly   550 STELQQLKDMSSH---QKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDF 611
            ...|.|.. :::|   :.|:|::            |..|..|.::| .:.:..|  :|:|:.:|.
  Fly   518 PWPLAQCW-VNAHLIDEPKQISQ------------GDIILLGRTNI-FRFNNPA--EAAKLRKDL 566

  Fly   612 TMARLFISKMK--TEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESM 674
            :.::|.:|::.  |.:|.....||....:..     .|.|::...:|      :..|..|..:..
  Fly   567 SRSQLDMSRLSLITSSKENLLTCSIYSDEDG-----ASPYKRPERQY------YPQRPMSRDDPE 620

  Fly   675 REAENKK--RTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQV 737
            .:.||:|  .|:|..:..|                |.|..|               :.:.:..:|
  Fly   621 LQDENRKILDTIENALKQL----------------NVERVQ---------------MHDQYKTKV 654

  Fly   738 SELRDE-IAAKQHEMD--EMKDVHQKLLLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQA 799
            .:|.:| |..:|.|||  ::.:..::.|:|.:.|.. :|| ..|..:.....:.|.....:.:..
  Fly   655 RKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLL-WEK-NNEKVQIDIVCRQISAFQTQLDSK 717

  Fly   800 RKDLKGLEDTVAKELQTLHNLRKL-------------------------------FVQDLQQRIR 833
            ::|   ..:.||||||.|.:..||                               |::|   .:|
  Fly   718 KRD---FSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAAQFIKD---TVR 776

  Fly   834 KNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKA 898
            :|  |||..:....:|:|::|  |..:..::.||.:.::...|.|        :|||
  Fly   777 RN--NEEIRKLDEQIAEKERI--LNASTTKIAKVDETMLEIQAQL--------ERLR-------- 821

  Fly   899 LETALKEAKEGAMRDRKRYQ---------------YEVDRIKEA----------VRQKHL----- 933
            ||.|..||:..|||.:|:..               .|.|.:.::          ..|.:|
  Fly   822 LERAESEAESQAMRAKKQNMKLQLGNKSMSTSTSTNEADDVSKSDTYETCDTFHTAQSNLSLVSS 886

  Fly   934 -----GRRGPQAQI-------AKPIR----------------------SGQGAIAIRGGGAVGGP 964
                 |::.|.:..       |:..|                      ||.|::.|.|.|:....
  Fly   887 PTITEGQQSPLSNCSCDAEDEAEDTRKDDLSGSSEETSRTCTAGPSSGSGSGSVGIGGSGSAPSC 951

  Fly   965 SPLAQ 969
            :|.:|
  Fly   952 TPSSQ 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	134/363 (37%)
		KISc	12..340	CDD:214526	135/370 (36%)
		Apolipoprotein	595..744	CDD:279749	27/153 (18%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	135/370 (36%)
		KISc	3..371	CDD:214526	135/370 (36%)
		Kinesin_assoc	370..478	CDD:292801	28/174 (16%)
		FHA	456..555	CDD:238017	20/114 (18%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950