Protein Alignment Khc and zgc:56231

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_998353.1
• Gene: zgc:56231 / 406257
• ZFINID: ZDB-GENE-040426-1914
• Length: 810
• Species: Danio rerio
• Alignment Length: 877
• Identity: 203/877 - (23%)
• Similarity: 337/877 - (38%)
• Gaps: 252/877 - (28%)

  Fly     2 SAEREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCI-------------------- 46
            |...||..:..::|..:.||.:..|.|          ||.::.|:
Zfish    41 SENAEIHEQQQLRVYLKVRPFSVEELK----------NNEDQGCVVLEDSETIVLHAPKGSASMK 95

  Fly    47 ----SIAGKVY--LFDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGV 105
                .|..:||  .|.::|.||.:|.:.:.....|.|...|.|.|..:|:||.|::|||:|::|.
Zfish    96 SSEKGIGQQVYKFSFSQIFGPNCNQTEFFEGTISSQVQAFLHGKNALVFSYGVTNAGKTYTIQGS 160

  Fly   106 IGDSVKQGIIPRIVNDIFNHI-------------------------------------------- 126
            ..|   .||:||.:..:|.||
Zfish   161 PKD---PGILPRALEVLFKHIGGRQYEHMDLKPYLSSDVQKLDSELVKLERNAKAALFSLLKEDP 222

  Fly   127 ---------------------------------YAMEVNLEFHIKVSYYEIYMDKIRDLLDVS-- 156
                                             .|.|.:..:.:.|::||||.:.:.|||..:
Zfish   223 EPTKLRKRSSTSSINSLSFSNVSYDHTVDSADGMADEAHCFYSVWVAFYEIYNEHVYDLLQPAQS 287

  Fly   157 -----KVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVF- 215
                 :..|.|.||.....|::......|.:.|:..:|:..|..||..|.|.||:.||||||:|
Zfish   288 SKTKRRAALRVCEDSTGSSYIRDLRWVNVQNTEEFSKVLRVGNKNRSAAATKMNQSSSRSHSIFT 352

  Fly   216 --LINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADG 278
              ||.::..:::...:||    |.||||||:.:||...|..|.||.|||.||..||..|:||.:.
Zfish   353 IKLIRIEGADVQALSELS----LCDLAGSERCNKTKTFGDRLKEAGNINNSLLILGKCIAALRNN 413

  Fly   279 ----NKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCV 339
                .|:::|:|:|||||:.|....|..|.::::..:..:....||...:.|...||.|..|:.
Zfish   414 QGFRTKSYVPFRESKLTRLFQGMFCGRGRASMIVNINQCASTYDETLHVMKFSAVAKQVLQVIP- 477

  Fly   340 NEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVE 404
                     .|..|....:...|.||      .|.:....:....::.::.|:|::....::.:
Zfish   478 ---------PRSLESLAPRIVGLDGK------PLLKNGVIDDQAVDDYLSEEELLDGDEADMSI- 526

  Fly   405 AAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQV 469
                        ..:..|.|:..|:.|.   .||...:.|.|       ||..:.:..:.:.:|:
Zfish   527 ------------LPQEELVNLVESLRVK---LLAERRKNLLQ-------EIQIRKEMGDAMLQQI 569

  Fly   470 MEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQ------ALEELAVNYDQKSQEIDNK 528
            ||.|||.:   |:.|.|:..   .:::.:|..|..||.|:      |||.|..:|
Zfish   570 MEAEELHS---RQMEDLKES---YEEKMDSTFEMYKEALKEHAYQCALERLEEDY---------- 618

  Fly   529 NKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSID 593
             ..|:...|| |::..|......||:        ||.|.:..|.|:               ....
Zfish   619 -IPIEEYKEE-QERVEVLEKRVCELE--------QKCRCSGPLPNV---------------QDNS 658

  Fly   594 LKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIA----QRCSNMETQQADSNKKISE----YE 650
            ::.:||..|:||..|. |.:    :.|.|...:|:.    :...::|.:..:.|..:.|    |.
Zfish   659 MQTNALPTTEASGAER-FKL----LYKEKCAVENLCVEKQEFIMSLEQRIGELNDTLQEAGESYM 718

  Fly   651 KDLGEYRLL---ISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVS------- 705
            :.|.|.:.|   :|..|..::.||.::       ...|::|..||||..|| |::.:.
Zfish   719 EKLAEVQNLQNRLSTREQEIECLQSNI-------MAKEKEITGLREEITKL-ASDSIGPPRSRCG 775

  Fly   706 -AVNAEEKQRAEELRSMFDSQMDELREAHTRQ 736
             .||.:|........|:..:....:|....|:
Zfish   776 LLVNIKESMTPPSTGSLCRTIRKSVRATSLRK 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	113/439 (26%)
		Smc	<341..>807	CDD:440809	85/421 (20%)
		Khc_CBD_cc	856..925	CDD:467880
zgc:56231	NP_998353.1	KISc_KIF23_like	50..470	CDD:276819	111/436 (25%)
		SMC_N	<464..>762	CDD:481474	81/389 (21%)