Protein Alignment Khc and Klp67A

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 1025
• Identity: 247/1025 - (24%)
• Similarity: 405/1025 - (39%)
• Gaps: 280/1025 - (27%)

  Fly     7 IPAED--SIKVVCRFRPLNDSEEKAGSKFVVK--------FPNNVEENCISIAG----------- 50
            :|:|.  :|||..|.||.|..|.:...:.::|        |..:.|::.....|
  Fly     1 MPSEQHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKR 65

  Fly    51 ---KVYL-FDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVK 111
               |:.: ||:||..:.|.:.::.|....:|..||.|||.::|.||.|.:|||.||   :|....
  Fly    66 MNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTM---LGSEAH 127

  Fly   112 QGIIPRIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGAT 176
            .|:....:.|:|:.|.|.....:|.:.|||.|:|.:.:.:||..|. .|.:.||.|.| .|.|..
  Fly   128 PGLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSG-PLKLREDNNGV-VVSGLC 190

  Fly   177 ERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAG 241
            ...:.|.|::..::..|.|:|....|:.|..|||||::|.::::....:...|.:.||.::||||
  Fly   191 LTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTVKLSMIDLAG 255

  Fly   242 SEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTI 306
            ||:.:.|...|....|..:|||||.||||.|:.||||.| |||||||.|||||::|||||.||.:
  Fly   256 SERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLK-HIPYRDSNLTRILKDSLGGNCRTLM 319

  Fly   307 VICCSPASFNESETKSTLDFGRRAKTVKNVVCVN---------------EELTAEEWKRRYEKEK 356
            |...|.:|....:|.:||.:..|||.::..:..|               :|:.||.     |:.|
  Fly   320 VANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAEN-----ERLK 379

  Fly   357 EKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTA 421
            |:|..|:.|..:||      |||.        :..|.:|..|...:::|...||.:    .|...
  Fly   380 ERNKALEAKATQLE------RAGN--------SGFDPLELKTWYSKIDAVYAAARQ----LQEHV 426

  Fly   422 LANMSASVAVNEQARLATECERLYQQLDDKDEEINQQ-----SQYAEQLKEQVMEQEELIANARR 481
            |...|....:|.:..|..|.|. :::|...|:.:.|:     :.|...|..|:.:.:|
  Fly   427 LGMRSKIKNINYRQTLKKELEE-FRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKE------- 483

  Fly   482 EYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQ-QKQSV 545
            |..:..|:|....|:.||.|.||.: .:|.:.|.|..         |.||:     ||| .||::
  Fly   484 ELPSWLSKMEIAYQDLESLKREVNK-SKAYQILIVYV---------KYKDL-----ELQLTKQNI 533

  Fly   546 F----NAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASK 606
            |    ||.:.||.:..|:.....:...|:| |...|..|.||.:.|
  Fly   534 FNNHVNAINQELVENLDLMRKSFRTACEVL-NQTYDRLEDGQKLTP------------------- 578

  Fly   607 VEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQ 671
                                                                   :.||..:.|.
  Fly   579 -------------------------------------------------------EIEAVFERLL 588

  Fly   672 ESMREAENKKRTLEEQIDSLREECAKLKAA----EHVSAVNAEEKQRAEELRSMFDSQMDELREA 732
            ..||.|:::..|...:::.|....|...:|    |...::.|..|:|
  Fly   589 RKMRFADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKR------------------ 635

  Fly   733 HTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKSSELQNIIL------ 791
             .||.::..|::.....:.|.            |...:|.|::.:......:..:..:|
  Fly   636 -QRQAAQSDDDLHLSMEDFDS------------QDTESDSEELHRTFKRPRNLNETQVLGPCSSS 687

  Fly   792 TNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQKQKISF 856
            ::.....:....|.|..||.|.            :.:|||:..:::::::...|..
  Fly   688 SSSSTSSSSSARKALTATVTKP------------RTVQQRLVSDLISDQNVRGGNE--------- 731

  Fly   857 LENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEV 921
                     |:.|.|::.|              ..|.:.::....|...|||..       :|..
  Fly   732 ---------KIKKALLKSN--------------HFTAQGLQRTLAAASLAKENV-------KYNA 766

  Fly   922 DRIKEAVRQKHLGRRGPQAQIAKPIRSGQGAIAIRGGGAVGGPSPLAQVN 971
            :.:          |:.|:|.:||.: :|...:|.:..|:.....||.:.|
  Fly   767 NYV----------RKSPRALMAKAL-AGTSTLARKPLGSASKEPPLVKFN 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	125/347 (36%)
		Smc	<341..>807	CDD:440809	91/485 (19%)
		Khc_CBD_cc	856..925	CDD:467880	10/68 (15%)
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	124/343 (36%)