DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and Klp61F

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster

Alignment Length:	1016	Identity:	273/1016 - (26%)
Similarity:	480/1016 - (47%)	Gaps:	184/1016 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SAEREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKF--PNNV--EENCISIAGKVYLFDKVFKPN 62
            |.:.:..:..:|:|..|.||||..|....|..||..  |..|  .....|...|.:.||:.|.|.
  Fly     9 SRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPE 73

  Fly    63 ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQ--------GIIPRIV 119
            :.|..||:.....::.:||.|||.|:||||||.:||||||.|.....:|.        |||||.:
  Fly    74 SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRAL 138

  Fly   120 NDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLL---DVSKVNLSVHEDKNRVPYVKGATERFVS 181
            :.:|:.:..|||  |:.:::||.|:|.:::.|||   |.:|:.:.....|.....::|..|..|.
  Fly   139 SHLFDELRMMEV--EYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVH 201

  Fly   182 SPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVF--LINVKQENLENQKKLS-GKLYLVDLAGSE 243
            |.:||::::|:||..|..|.|.||..|||||:||  ::::::..:|.:..|. |||.||||||||
  Fly   202 SKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSE 266

  Fly   244 KVSKTGAE-GTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIV 307
            .|||.|.| |..:.|..|||:||..||.||:||.| ...|:|||:|||||:|||||||..:|:|:
  Fly   267 NVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSII 330

  Fly   308 ICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNAR-LKGKVEKLEI 371
            ...||...:..||.|||::..|||.::|...||::||.:...:.|.:|.:|..| |....:|..|
  Fly   331 ATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGI 395

  Fly   372 ELARWRAGE-TVKAEEQ---INMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVN 432
            .||....|| |:|.|.|   :|.:.|:                    |.|.:..|.|.
  Fly   396 YLAEETYGEITLKLESQNRELNEKMLL--------------------LKALKDELQNK------- 433

  Fly   433 EQARLATECERLYQQ----LDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARI 493
                     |:::.:    |.:|.:|:.:..:.....|..::..::::...:|.|:..:..:|..
  Fly   434 ---------EKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASH 489

  Fly   494 QQENESAKEEVKEVLQALEELAVNYD-------QKSQEIDNK-NKDIDALNEELQQKQSVFNAAS 550
            .:..:....:.:|:| |..:||.:..       ::.:|:|.| .:..|...:.:|....:...:
  Fly   490 MKTEQVLTTQAQEIL-AAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGS- 552

  Fly   551 TELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGES-SIDL--KMSALAGTDASKVEEDFT 612
              |...:|..:..|:::::.:.|    ...|.|.:|...| ||::  :|.|.:..|.:.:.....
  Fly   553 --LNLYQDQQAALKEQLSQEMVN----SSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLI 611

  Fly   613 MARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMRE- 676
            ...:.||...::| .:|:....|:.||...:|:|....:       :|.::..|.|::.:||:|
  Fly   612 GEVMKISDQHSQA-FVAKLMEQMQQQQLLMSKEIQTNLQ-------VIEENNQRHKAMLDSMQEK 668

  Fly   677 ----AENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEE---------------LRSMF 722
                .::..:::||....:.::..:|.|   :|..:|||.|..:|               |.||.
  Fly   669 FATIIDSSLQSVEEHAKQMHKKLEQLGA---MSLPDAEELQNLQEELANERALAQQEDALLESMM 730

  Fly   723 DSQMDELREAHTR-------QVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDA 780
             .||::::...::       .::::.:....:.|.:|::|...|           ||:|:..| |
  Fly   731 -MQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQ-----------DYQKLGIE-A 782

  Fly   781 EKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDG 845
            .:|::.:   ||:    |....:..|:..||.     .::.::.:::|.|:..|     |:.|:.
  Fly   783 SQSAQAE---LTS----QMEAGMLCLDQGVAN-----CSMLQVHMKNLNQKYEK-----ETNENV 830

  Fly   846 GSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKA-LETALKEAKEG 909
            ||:                 :||    .:..::.|:..|  ::|....|:.:. ||..:...::.
  Fly   831 GSV-----------------RVH----HNQVEIICQESK--QQLEAVQEKTEVNLEQMVDARQQL 872

  Fly   910 AMRDRKRY----QYEVDRIKEAVRQ--KHLGRRGPQAQIAK 944
            ...||:|:    ....|.::|:.||  :|...:..|.||.:
  Fly   873 ITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICE 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	143/341 (42%)
		KISc	12..340	CDD:214526	144/346 (42%)
		Apolipoprotein	595..744	CDD:279749	33/175 (19%)
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	146/350 (42%)
		Kinesin	25..356	CDD:278646	141/333 (42%)
		Microtub_bind	923..>1009	CDD:290642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.850