DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and KIF5C

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_004513.1	Gene:	KIF5C / 3800	HGNCID:	6325	Length:	957	Species:	Homo sapiens

Alignment Length:	971	Identity:	597/971 - (61%)
Similarity:	748/971 - (77%)	Gaps:	47/971 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            |||.||||:|||||||::|...|.||:.||..  :|..:...||.|:||:|..||.:||:|||..
Human     4 PAECSIKVMCRFRPLNEAEILRGDKFIPKFKG--DETVVIGQGKPYVFDRVLPPNTTQEQVYNAC 66

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHI 137
            ||.||.|||.||||||||||||||||||||||.:.|....||||||.:|||:|||:|:.||||||
Human    67 AKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHI 131

  Fly   138 KVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVT 202
            ||||:|||:|||||||||||.||:|||||||||||||.|||||||||:|.:||:|||:|||:|||
Human   132 KVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVT 196

  Fly   203 NMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSA 267
            |||||||||||:||||:||||:|.:|||||||||||||||||||||||||.||||||||||||||
Human   197 NMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSA 261

  Fly   268 LGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKT 332
            |||||||||:|.|||:||||||:|||||:|||||.||||||||||:.|||:||||||.||:||||
Human   262 LGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   333 VKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEA- 396
            :||.|.||.||||||||::||||||||..||..::.||:||.|||.||.|..:|||:.:|....
Human   327 IKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDEQISAKDQKNLE 391

  Fly   397 ---STPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQ 458
               :||.::                  .:|.:.|.::..|:.:...|...||:||||||:|||||
Human   392 PCDNTPIID------------------NIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQ 438

  Fly   459 SQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQ 523
            ||.||:||:|:::|:||:|:.||:||.:|.|:.|:|.|||:||:|||||||||||||||||||||
Human   439 SQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYDQKSQ 503

  Fly   524 EIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPG 588
            |:::|.:..:.|.:||.||.:.......||.||:::|:|||||.||:|..||:||||:|..|...
Human   504 EVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTN 568

  Fly   589 ESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDL 653
            :      :..||..: ..:||:||||||:|||||:|.|::..|...:|:.|.|||:|::..|::|
Human   569 D------VKTLADVN-GVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKMNASEREL 626

  Fly   654 GEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQR---- 714
            ...:||||||||::|||.:.|:..|.|:|.|||..|||.||.|||:|.|.:..|:.::|::
Human   627 AACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLT 691

  Fly   715 ----AEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKV 775
                |||::...:.||:..||||.:|:|.|||||..||..:||::|::|||.|..:::::||.|:
Human   692 RLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKL 756

  Fly   776 RQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEE 840
            :.||.|:..:|:.::|.|::|||||:||||||:||::||||||||||||||||..|::|: |..:
Human   757 KIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKS-VELD 820

  Fly   841 SEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKE 905
            :::.|||.|||||||||||||:||||||||||||||||||||||||||||.|.|||||||:||||
Human   821 NDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKE 885

  Fly   906 AKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQ-------GAIAIRGGG 959
            |||.|||||||||.||||||||||.|::.||...||||||||.|.       ...||||||
Human   886 AKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGG 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	247/322 (77%)
		KISc	12..340	CDD:214526	250/327 (76%)
		Apolipoprotein	595..744	CDD:279749	70/156 (45%)
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	247/322 (77%)
		Microtubule-binding	174..315		119/140 (85%)
		Smc	<460..801	CDD:224117	171/347 (49%)
		PRK03918	<715..>916	CDD:235175	136/201 (68%)
		Globular	859..956		64/88 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..957		18/36 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	646	1.000	Domainoid score	I161
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1143	1.000	Inparanoid score	I213
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm40436
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870