DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and KIF5B

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_004512.1	Gene:	KIF5B / 3799	HGNCID:	6324	Length:	963	Species:	Homo sapiens

Alignment Length:	972	Identity:	596/972 - (61%)
Similarity:	745/972 - (76%)	Gaps:	34/972 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEAA 73
            ||.:|||:|||||||:||...|.|::.||..   |:.:.||.|.|.||:||:.:.|||:|||:.|
Human     5 AECNIKVMCRFRPLNESEVNRGDKYIAKFQG---EDTVVIASKPYAFDRVFQSSTSQEQVYNDCA 66

  Fly    74 KSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHIK 138
            |.||.|||.||||||||||||||||||||||.:.|....|||||||.||||:||:|:.|||||||
Human    67 KKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIK 131

  Fly   139 VSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTN 203
            |||:|||:|||||||||||.||||||||||||||||.|||||.||::|.:.|:|||||||:||||
Human   132 VSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTN 196

  Fly   204 MNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSAL 268
            ||||||||||:|||||||||.:.::||||||||||||||||||||||||.|||||||||||||||
Human   197 MNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSAL 261

  Fly   269 GNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTV 333
            ||||||||:|: |::||||||:|||||:|||||.||||||||||:|:|||||||||.||:||||:
Human   262 GNVISALAEGS-TYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTI 325

  Fly   334 KNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEAST 398
            ||.||||.|||||:||::||||||||..|:..::.||.||.|||.||||..:||.:.|      .
Human   326 KNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKE------K 384

  Fly   399 PNLEVEAAQTAAAEAALAAQRTALA-NMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYA 462
            .|||   |.|...:..|...:.|.| .:..:....|:.:...|..:||:||||||||||||||..
Human   385 ANLE---AFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLV 446

  Fly   463 EQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDN 527
            |:||.|:::||||:|:.||:.:.:|:|:.|:|.||:::||||||||||||||||||||||||:::
Human   447 EKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVED 511

  Fly   528 KNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSI 592
            |.|:.:.|::||.||.:...:...|||:||:|::|||||..||:.:||:||.|:|  ||.|.:
Human   512 KTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIG--IAVGNN-- 572

  Fly   593 DLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYR 657
            |:|.....|    .::|:||:|||:|||||:|.|.:.:||..:|:.|.:||||:.|.||:|...:
Human   573 DVKQPEGTG----MIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQ 633

  Fly   658 LLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAE---EKQRAEELR 719
            |.||||||::|||.|.::..|.|||.|||.:|:|.||..:|:|.|.|..:..|   :.|.|.|::
Human   634 LRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVK 698

  Fly   720 SMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKSS 784
            ...:.|:...||.|.:|:|.||||:.||...:.:::|.:||::|..:::..::||::..|.|||.
Human   699 QAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSR 763

  Fly   785 ELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLA 849
            :|..:.:..:||||||:||||||:||||||||||||||||||||..|::|: ...:|::.|||.|
Human   764 KLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKS-AEIDSDDTGGSAA 827

  Fly   850 QKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDR 914
            ||||||||||||:||||||||||||||||||||||||||||.|.|||||||:|||||||.|.|||
Human   828 QKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDR 892

  Fly   915 KRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQGAI-------AIRGGGA-VGGPSPLA 968
            ||||.||||||||||.|::.|||..||||||||.||...       ||||||| |....|:|
Human   893 KRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVA 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	245/322 (76%)
		KISc	12..340	CDD:214526	249/327 (76%)
		Apolipoprotein	595..744	CDD:279749	66/151 (44%)
KIF5B	NP_004512.1	KISc_KHC_KIF5	6..325	CDD:276820	245/322 (76%)
		KISc	8..332	CDD:214526	249/327 (76%)
		DUF4337	<462..>538	CDD:290935	40/75 (53%)
		TACC	467..662	CDD:282818	103/202 (51%)
		TMPIT	598..>686	CDD:285135	41/87 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..963		24/47 (51%)
		Globular	915..963		21/40 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160263
Domainoid	1	1.000	646	1.000	Domainoid score	I161
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55829
Inparanoid	1	1.050	1143	1.000	Inparanoid score	I213
Isobase	1	0.950	-	0	Normalized mean entropy	S1747
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm40436
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750