DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and KIF5A

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_004975.2	Gene:	KIF5A / 3798	HGNCID:	6323	Length:	1032	Species:	Homo sapiens

Alignment Length:	950	Identity:	568/950 - (59%)
Similarity:	722/950 - (76%)	Gaps:	41/950 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEAAK 74
            |.||||:|||||||.:|...|.||:..|..   ::.:.|.||.|:||:||.||.:||:||:..|.
Human     7 ECSIKVLCRFRPLNQAEILRGDKFIPIFQG---DDSVVIGGKPYVFDRVFPPNTTQEQVYHACAM 68

  Fly    75 SIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHIKV 139
            .||.||||||||||||||||||||||||||.:.|....||||||..|||||||:|:.||||||||
Human    69 QIVKDVLAGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIKV 133

  Fly   140 SYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNM 204
            ||:|||:|||||||||:|.||||||||||||:|||.|||||||||::.:||:|||||||:|||||
Human   134 SYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFVKGCTERFVSSPEEILDVIDEGKSNRHVAVTNM 198

  Fly   205 NEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALG 269
            |||||||||:||||:||||:|.::||||||||||||||||||||||||.||||||||||||||||
Human   199 NEHSSRSHSIFLINIKQENMETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALG 263

  Fly   270 NVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVK 334
            |||||||:|.|:::||||||:|||||:|||||.|||:.|||||:|:|::||||||.||:||||:|
Human   264 NVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFGQRAKTIK 328

  Fly   335 NVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTP 399
            |...||.|||||:||::|||||||....|..:.|||.||:|||.||.|...|::
Human   329 NTASVNLELTAEQWKKKYEKEKEKTKAQKETIAKLEAELSRWRNGENVPETERL----------- 382

  Fly   400 NLEVEAAQTAAAEAALAAQ--RTALANMSASVAV----NEQARLATECERLYQQLDDKDEEINQQ 458
                     |..||||.|:  .....|.::|:.|    .|:.:...|..|||:||||||:|||||
Human   383 ---------AGEEAALGAELCEETPVNDNSSIVVRIAPEERQKYEEEIRRLYKQLDDKDDEINQQ 438

  Fly   459 SQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQ 523
            ||..|:||:|:::||||:.:.|.:.|.:|.|::.:|.||::||:|||||||||||||||||||||
Human   439 SQLIEKLKQQMLDQEELLVSTRGDNEKVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKSQ 503

  Fly   524 EIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPG 588
            |::.|::....|.:||.||.:...:..:|||:|:::|.||:|||.|:|..|::||.|....:..|
Human   504 EVEEKSQQNQLLVDELSQKVATMLSLESELQRLQEVSGHQRKRIAEVLNGLMKDLSEFSVIVGNG 568

  Fly   589 ESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDL 653
            |..:.:::|       ..:||:||:|||:|||:|:|.|::.:||..:|..|.:.::|:....::|
Human   569 EIKLPVEIS-------GAIEEEFTVARLYISKIKSEVKSVVKRCRQLENLQVECHRKMEVTGREL 626

  Fly   654 GEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEK----QR 714
            ...:||||||||:::||.|.|:..|.|||.|||..|||.:|.|||:|.|.|..|..::|    |.
Human   627 SSCQLLISQHEAKIRSLTEYMQSVELKKRHLEESYDSLSDELAKLQAQETVHEVALKDKEPDTQD 691

  Fly   715 AEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQED 779
            |:|::...:.||:..||||.||::.|||||..||..:||:||::|||.|..:::.|||||::.|:
Human   692 ADEVKKALELQMESHREAHHRQLARLRDEINEKQKTIDELKDLNQKLQLELEKLQADYEKLKSEE 756

  Fly   780 AEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEED 844
            .|||::||.:....||.||:::||||||:|||:|||||||||||||||:..|::|: ...|.|:.
Human   757 HEKSTKLQELTFLYERHEQSKQDLKGLEETVARELQTLHNLRKLFVQDVTTRVKKS-AEMEPEDS 820

  Fly   845 GGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEG 909
            ||..:||||||||||||:||||||||||||||||||||||||||||.|.|||||||.||||||||
Human   821 GGIHSQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKEG 885

  Fly   910 AMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSG 949
            ||:|::|||.||||||||||.|..|:||..||||||:|.|
Human   886 AMKDKRRYQQEVDRIKEAVRYKSSGKRGHSAQIAKPVRPG 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	240/322 (75%)
		KISc	12..340	CDD:214526	242/327 (74%)
		Apolipoprotein	595..744	CDD:279749	65/152 (43%)
KIF5A	NP_004975.2	KISc_KHC_KIF5	7..327	CDD:276820	240/322 (75%)
		Microtubule-binding	174..315		113/140 (81%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000250\|UniProtKB:P33175	271..361		59/89 (66%)
		Interaction with BICD2. /evidence=ECO:0000269\|PubMed:20386726	353..1032		308/600 (51%)
		Smc	<412..759	CDD:224117	164/353 (46%)
		DUF5401	<630..>902	CDD:375164	169/272 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..939		11/19 (58%)
		Globular	907..1032		11/18 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1010
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	646	1.000	Domainoid score	I161
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1143	1.000	Inparanoid score	I213
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm40436
orthoMCL	1	0.900	-	-		OOG6_100344
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2595
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870