DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc and Klp59D

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_611762.1	Gene:	Klp59D / 37674	FlyBaseID:	FBgn0034827	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	160/537 - (29%)
Similarity:	244/537 - (45%)	Gaps:	72/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKVVCRFRPLNDSEEKAGSKFVVKFPNN----VEENCISIAGKVYL------FDKVFKPNASQEK 67
            |.|..|.||::..||.:.:..::..|:.    |.|..:.:....:|      ||..|....|...
  Fly   234 ITVCVRKRPMSRKEENSKNLDIITVPSADSLIVHELRLKVDLTKFLEHHKFRFDYTFDEECSNAL 298

  Fly    68 VYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQ---GIIPRIVNDIFNHIYAM 129
            ||:..|:.::..:..|.|.|.||||||.|||||||.|.....|:.   ||......|:|..:...
  Fly   299 VYDHTARPLIRTMFEGGNATCFAYGQTGSGKTHTMGGEFFGKVQDCGTGIYAMAARDVFEEVSRP 363

  Fly   130 EV-NLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEG 193
            |. .:...|..|::|||..|:.|||..:|..|.|.||..:...|.|.||..|:..|||..:||.|
  Fly   364 EYRQMGAKITCSFFEIYGTKVFDLLLPNKPMLRVLEDARQQVVVVGLTEMPVTKVEDVLRLIEHG 428

  Fly   194 KSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKT-GAEGTVLDE 257
            ...|....|:.|..|||||:||.|.:   :..:.....||...|||||:|:.:.| .|:.....|
  Fly   429 SKERTSGQTSANAKSSRSHAVFQIAL---HFPDSWGPHGKCSFVDLAGNERGADTQSADRQTRIE 490

  Fly   258 AKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQES-LGGNA-RTTIVICCSPASFNESET 320
            ...|||||.||...|.||: ...:|:|:|.||||::|::| :||.. :|.::...||:......|
  Fly   491 GAEINKSLLALKECIRALS-RQSSHLPFRGSKLTQVLRDSFVGGKKNKTCMIAMISPSMSCVENT 554

  Fly   321 KSTLDFGRRAKTVKNVVCVNEELTA--EEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVK 383
            .:||.:..|.|          ||.|  :|..:..|.:.||:..|.   |:.|.|:         .
  Fly   555 LNTLRYADRVK----------ELIAKEDEHLQSVEGDGEKSPDLN---EESEPEM---------M 597

  Fly   384 AEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQL 448
            |:|:.:.|       |..|.....|.::|.|     ::..|||..::.|....:......:
  Fly   598 ADEEGDEE-------PEDEDNQHLTISSEEA-----SSYNNMSYDMSFNHTLNILGPSRNV---- 646

  Fly   449 DDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEE 513
             |..|...|.:...|.|        |..|:..|:.:| ..|:.:..|.:|||..::..::....:
  Fly   647 -DIQEVAEQHALLVENL--------ETYAHNFRQLKT-DKEIEQYTQNSESALMKLLAMVNRTRD 701

  Fly   514 LAVNYD-QKSQEIDNKN 529
            :..||: ||..:.:|:|
  Fly   702 VTHNYNTQKLLKEENQN 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	117/336 (35%)
		KISc	12..340	CDD:214526	117/343 (34%)
		Apolipoprotein	595..744	CDD:279749
Klp59D	NP_611762.1	KISc_KIF2_like	233..565	CDD:276818	116/334 (35%)
Klp59D	NP_611762.1	Kinesin	239..566	CDD:278646	115/340 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940