DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc and Klp59C

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_611759.1	Gene:	Klp59C / 37671	FlyBaseID:	FBgn0034824	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	142/466 - (30%)
Similarity:	209/466 - (44%)	Gaps:	69/466 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKVVCRFRPLNDSEEKAGSKFVVKFPNN----VEE-----NCIS-IAGKVYLFDKVFKPNASQEK 67
            |.|..|.|||...|.....:.||..|:.    |.|     |.:. :....:.||.||....|...
  Fly   188 IMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNAT 252

  Fly    68 VYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVI---GDSVKQGIIPRIVNDIFNHIYAM 129
            ||...|:.::..:..|...|.||||||.||||:||.|..   ..|...||......|:|:.:..:
  Fly   253 VYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTV 317

  Fly   130 EVN-LEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEG 193
            ..| |...:..|::|||..::.|||...|..|.|.||:|:...|.|.|:..|.:..:|.:::|.|
  Fly   318 PYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELG 382

  Fly   194 KSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLD-- 256
            .|.|....|:.|..|||||:||.|.::....|   ||.||..|:||||:|:    ||:.:..|
  Fly   383 NSVRTSGHTSANSKSSRSHAVFQIVLRSAAGE---KLHGKFSLIDLAGNER----GADNSSADRQ 440

  Fly   257 ---EAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQES-LGG-NARTTIVICCSPASFN 316
               |...|||||..|...|.||. ...:|:|:|.||||::|::| :|| ..:|.::...||...:
  Fly   441 TRLEGSEINKSLLVLKECIRALG-RQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHS 504

  Fly   317 ESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGET 381
            ...|.:||.:..|.|          ||:.|.    ...::..:|.|                |.|
  Fly   505 VEHTLNTLRYADRVK----------ELSVES----IPSKRMPDANL----------------GST 539

  Fly   382 VKAEEQINMEDLM-EASTPNLEVEAAQTAAAEAA-LAAQRTALAN-MSASVAVNEQARLATECER 443
                   :|.|:: ::||..|...|:.|:..... .|.|.|..|| ::.|.....:....|..::
  Fly   540 -------SMSDIVCQSSTQRLFPCASSTSMPGGGNQAQQHTNTANDLNRSQKPTSKPTYPTSGQQ 597

  Fly   444 LYQQLDDKDEE 454
            |.|:......|
  Fly   598 LVQRKGSSQRE 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	118/340 (35%)
		KISc	12..340	CDD:214526	118/347 (34%)
		Apolipoprotein	595..744	CDD:279749
Klp59C	NP_611759.1	KISc_KIF2_like	187..519	CDD:276818	117/338 (35%)
Klp59C	NP_611759.1	Kinesin	193..520	CDD:278646	116/344 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030