DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and KIF7

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_011519833.1	Gene:	KIF7 / 374654	HGNCID:	30497	Length:	1384	Species:	Homo sapiens

Alignment Length:	1319	Identity:	303/1319 - (22%)
Similarity:	497/1319 - (37%)	Gaps:	458/1319 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAEREIPAEDS-IKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISI---AGKVYL------- 54
            :.|:|...||:: ::|..|.|||...|...|           .::|:.:   .|:|.|
Human    44 LEAQRLPGAEEAPVRVALRVRPLLPKELLHG-----------HQSCLQVEPGLGRVTLGRDRHFG 97

  Fly    55 FDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTM-EGVIGDSV--KQGIIP 116
            |..|...:|.||.||....:.::.....|:|.|:||||||.||||:|| |..:...:  :|||:|
Human    98 FHVVLAEDAGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLLEDEQGIVP 162

  Fly   117 RIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKV--NLSVHEDKNRVPYVKGATERF 179
            |.:.:.|..|...:: |:..:.|||.|:|.::.||||:|...  ::.:.||:.....:.|..|..
Human   163 RAMAEAFKLIDENDL-LDCLVHVSYLEVYKEEFRDLLEVGTASRDIQLREDERGNVVLCGVKEVD 226

  Fly   180 VSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQK--------KLSGKLYL 236
            |...::|..::|.|.:.||...|::|..|||||:||.:.::|......:        .|..|.:.
Human   227 VEGLDEVLSLLEMGNAARHTGATHLNHLSSRSHTVFTVTLEQRGRAPSRLPRPAPGQLLVSKFHF 291

  Fly   237 VDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNK--THIPYRDSKLTRILQESLG 299
            |||||||:|.|||:.|..|.|:..||.||.|||||||||.|..:  :||||||||:||||::|||
Human   292 VDLAGSERVLKTGSTGERLKESIQINSSLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLG 356

  Fly   300 GNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNA---- 360
            |||:|.::.|.||:|.:..||.:||::..||:.::|...||       |:...|:..|:.|
Human   357 GNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVN-------WRPEAERPPEETASGAR 414

  Fly   361 ----------------RLKGKVE-------KLEIELARWRAG--------ETVKAEEQI------ 388
                            |..|...       :|..|.||:||.        ..::||..:
Human   415 GPPRHRSETRIIHRGRRAPGPATASAAAAMRLGAECARYRACTDAAYSLLRELQAEPGLPGAAAR 479

  Fly   389 NMED-----------LMEASTPNLEVEAA--QTAAAEAALAAQRTALANMSASVAVNEQARLATE 440
            .:.|           |..||.|:..:|:|  :..||:.|...:....|....::. |:.|||..|
Human   480 KVRDWLCAVEGERSALSSASGPDSGIESASVEDQAAQGAGGRKEDEGAQQLLTLQ-NQVARLEEE 543

  Fly   441 CERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEEL------------------------------ 475
            .......|:|..|:...||   ::|:||..|..||
Human   544 NRDFLAALEDAMEQYKLQS---DRLREQQEEMVELRLRLELVRPGWGGPRLLNGLPPGSFVPRPH 605

  Fly   476 ---------------------------------IANARREYETLQSEMARIQQENESAKEEVKE- 506
                                             :.|.|.....|.:|:.|:...:.:|.||.:|
Human   606 TAPLGGAHAHVLGMVPPACLPGDEVGSEQRGEQVTNGREAGAELLTEVNRLGSGSSAASEEEEEE 670

  Fly   507 ----------------------------------------------------------------- 506

Human   671 EEPPRRTLHLRRNRISNCSQRAGARPGSLPERKGPELCLEELDAAIPGSRAVGGSKARVQARQVP 735

  Fly   507 -----------VLQALEELAVNYDQKSQ---EIDNKNKDIDALNEELQQKQSVFNAASTELQQLK 557
                       ..|.:.|||:|...|.:   |:....|...|||.:..|:   ......|.:|::
Human   736 PATASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQHSQR---IRELEQEAEQVR 797

  Fly   558 DMSSHQKKRITEMLTNLLRDLG------EVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARL 616
            ...|..::::.|:....|:|.|      |..:.:|..:|.:
Human   798 AELSEGQRQLRELEGKELQDAGERSRLQEFRRRVAAAQSQV------------------------ 838

  Fly   617 FISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMREAENKK 681
               ::..|.|...:|..::..|   |.|::.|.|:::    .|:.|.:.:   ||..:||...:|
Human   839 ---QVLKEKKQATERLVSLSAQ---SEKRLQELERNV----QLMRQQQGQ---LQRRLREETEQK 890

  Fly   682 RTLEEQIDSLR---------------------EECA----KLKAAEHVSAVNAEEKQRAEELRSM 721
            |.||.::...:                     ||.|    |.::..:.|.|:.|::|:.||.:..
Human   891 RRLEAEMSKRQHRVKELELKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQKKW 955

  Fly   722 FDSQMDELREAHTRQVSELRDE-------IAAKQHEMDEMKDVHQKLLLAHQQMTAD-------Y 772
            .|.:|:::.: ..|.:.||.:|       :|.|:..|.|...:..|.|.:.|.:..|       .
Human   956 LDQEMEKVLQ-QRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRL 1019

  Fly   773 EKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVV 837
            |.:.:|.:|||.:|:      :...|:::.::|..|::.:|..:|          |:||:
Human  1020 EHLEKELSEKSGQLR------QGSAQSQQQIRGEIDSLRQEKDSL----------LKQRL----- 1063

  Fly   838 NEESEEDG----GSLAQKQKISFLENNLDQLTKV-----------------HKQLVRDNADL--R 879
                |.||    |||...::    |..|.||.:.                 .::::|.:|.|  :
Human  1064 ----EIDGKLRQGSLLSPEE----ERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRASASLLSQ 1120

  Fly   880 CEL---------------------------------------PKLEKRLRCTMERVKALETALKE 905
            ||:                                       .:||.:|......|..||.||:.
Human  1121 CEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYWLEVALER 1185

  Fly   906 AK------------------------------EGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQA 940
            .:                              ||....|::|:..:..:     :|.|||.....
Human  1186 QRLEMDRQLTLQQKEHEQNMQLLLQQSRDHLGEGLADSRRQYEARIQAL-----EKELGRYMWIN 1245

  Fly   941 QIAKPIRSGQGAIAIRGGG 959
            |..|....|..|:....||
Human  1246 QELKQKLGGVNAVGHSRGG 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	132/348 (38%)
		KISc	12..340	CDD:214526	132/353 (37%)
		Apolipoprotein	595..744	CDD:279749	34/180 (19%)
KIF7	XP_011519833.1	KISc	56..397	CDD:214526	132/352 (38%)
		KISc_KIF4	56..391	CDD:276823	131/346 (38%)
		TPP_enzymes	<541..615	CDD:294952	12/76 (16%)
		FAM184	774..993	CDD:292293	51/259 (20%)
		Utp11	891..1069	CDD:295201	44/203 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910