DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and unc-104

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_611155.3	Gene:	unc-104 / 36876	FlyBaseID:	FBgn0267002	Length:	1739	Species:	Drosophila melanogaster

Alignment Length:	1262	Identity:	308/1262 - (24%)
Similarity:	495/1262 - (39%)	Gaps:	385/1262 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SIKVVCRFRPLNDSEEKAGSKFVV------------KFPNNVEENCISIAGKVYLFDKVFKPN-- 62
            |:||..|.||.|..|....||.::            |.|.|..::.     |.:.||..:..:
  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSV-----KRFNFDYSYWSHDH 62

  Fly    63 -----ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDI 122
                 ::|..||.:..:.::.....|||..|||||||.:||::||.| ..:..::||||.|..|:
  Fly    63 HDADFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMG-RQEEQQEGIIPMICKDL 126

  Fly   123 FNHIYAMEV-NLEFHIKVSYYEIYMDKIRDLLD-VSKVNLSVHEDKNRVPYVKGATERFVSSPED 185
            |..|...|. :|::.::|||.|||.:::||||: .:|.||.|.|.....|||:..::..|:..:|
  Fly   127 FTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTDYQD 191

  Fly   186 VFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQE------NLENQKKLSGKLYLVDLAGSEK 244
            :.::|:||...|.:|.|||||.|||||:||.|...|.      ||..:|  ..|:.||||||||:
  Fly   192 IHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRHDLMTNLTTEK--VSKISLVDLAGSER 254

  Fly   245 VSKTGAEGTVLDEAKNINKSLSALGNVISALAD--GNKTH------IPYRDSKLTRILQESLGGN 301
            ...|||:||.|.|..||||||:.||.||||||:  ..|.:      ||||||.||.:|:|:||||
  Fly   255 ADSTGAKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGN 319

  Fly   302 ARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKV 366
            ::|.::...|||..|..||.|||.:..|||.:.....|||:..|:..:           .||.::
  Fly   320 SKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAKLIR-----------ELKEEI 373

  Fly   367 EKLEIELARWRAGETVKAEEQINMEDLMEASTPN-------LEVEAAQTAAAEAALA-------- 416
            :||. :|.: ..|..|:.|:::....::::.|.:       .|:...|..|:|..:|
  Fly   374 QKLR-DLLK-AEGIEVQEEDELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELNETWEE 436

  Fly   417 ---------AQRTAL-ANMSASVA-------------------VNEQARLATECERLY-----QQ 447
                     .||.|: |.|..:|.                   :||...| :||...|     .:
  Fly   437 KLKRTEEIRVQREAVFAEMGVAVKEDGITVGVFSPKKTPHLVNLNEDPNL-SECLLYYIKEGLTR 500

  Fly   448 LDDKDEEINQQSQYAEQ--LKEQVMEQEE-------------LIANARR--EYETLQS------- 488
            |...:..:.|..|.:..  |||....:.:             :..|.|:  |.|.|::
  Fly   501 LGTHEANVPQDIQLSGSHILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILG 565

  Fly   489 ----------EMAR-----IQQENESAKE----------------------------EVKEVLQA 510
                      |.||     |:.|||:..|                            |:|:.|..
  Fly   566 KNHVFRFTNPEQARELRDKIETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKRLDN 630

  Fly   511 LEELAVNYD----QKSQEIDNKNKD----IDALNEELQQK---QSVFNAASTE-LQQLKDMSSHQ 563
            |||   .|.    |..|:.:.:.|.    ||||.::::::   .|::::.|.| ..|.:|:.::.
  Fly   631 LEE---QYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNP 692

  Fly   564 ------------------KKRITEMLTNLLRDLGEVGQAIAPGES---SIDLKMSA--------- 598
                              :|......|:|..||.  |.||...|:   |::||...
  Fly   693 MYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLW--GNAIFLKEANAISVELKKKVQFQFTLLTD 755

  Fly   599 ---------LAGTDASKVEEDF----TMARLFISKMKTEAKN----------------IAQRCSN 634
                     ||.|.|...:||.    .:::..::...|:.||                :.::..|
  Fly   756 TLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYN 820

  Fly   635 METQQADSNKKISEYEKDLGEYRLLISQH---EARMKSLQESMREAENKKRTLEEQIDSLREECA 696
            :|:..:......|..|. |..:....|||   :|::..|:..: |:|..:.||...|.|
  Fly   821 VESPPSSMLFDTSGMEA-LSGWISPPSQHPGQQAQLLPLEPPV-ESERGRLTLANLIPS------ 877

  Fly   697 KLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRD------------------- 742
                           :||.|.:|.|:.::.:....:....|..|..
  Fly   878 ---------------RQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFI 927

  Fly   743 ---------EIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKV--------------RQEDAEKSS 784
                     .:..|...::|..||...|.:|.|.: .|.|.:              .::||:...
  Fly   928 YLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV-LDEESIDFNNGVKQSARLVFNEDDAKPKY 991

  Fly   785 ELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLA 849
            .     ..||:.:..|....|..|:..:||:.:.:.|.:......:      .:|.|||.|..|.
  Fly   992 R-----ALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASE------CHENSEEPGEHLQ 1045

  Fly   850 QKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALET-ALKEAKEGAMRD 913
            ..::.:|....| |.|.:..:.    ||:.|:...|.:       ..:|..| .:|.:..||...
  Fly  1046 VGKEFTFRVTVL-QATGIGAEY----ADIFCQFNFLHR-------HEEAFSTEPVKNSASGAPLG 1098

  Fly   914 RKRYQ--------------------------YEVDRIKEAVRQKHLGRRGPQAQ------IAKPI 946
            ....|                          |:...:.:..:|..:.|..|:..      |::|:
  Fly  1099 FYHVQNITVPVTKSFIEYLKTQPIMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPV 1163

  Fly   947 RSGQGAIAIRGGGAVGGPSPLAQVNPV 973
            ||.:           .||.|.|..:.|
  Fly  1164 RSPK-----------FGPLPCAPTSTV 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	144/355 (41%)
		KISc	12..340	CDD:214526	144/362 (40%)
		Apolipoprotein	595..744	CDD:279749	33/217 (15%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	144/362 (40%)
		KISc	3..358	CDD:214526	144/362 (40%)
		Kinesin_assoc	355..498	CDD:292801	30/156 (19%)
		FHA	475..574	CDD:238017	17/99 (17%)
		KIF1B	878..923	CDD:289208	7/44 (16%)
		DUF3694	1246..1347	CDD:289256
		PH_KIFIA_KIFIB	1602..1704	CDD:269939
		PH	1607..1700	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940