Protein Alignment Khc and Khc-73

DIOPT Version :9

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 1177
• Identity: 286/1177 - (24%)
• Similarity: 450/1177 - (38%)
• Gaps: 391/1177 - (33%)

  Fly     9 AEDSIKVVCRFRPLNDSEEKAGSKFVVKFP------------NNVEENCISIAGKVYLFDKVF-- 59
            |.|.|||..|.||.|..|.:..:|.:|:..            ..:|..    ..|.:.||..|
  Fly     2 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERK----QPKTFAFDHCFYS 62

  Fly    60 -KPN----ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIV 119
             .|.    ||||.|::...:.|:.:...|||..|||||||.|||::||   :|....:|||||:.
  Fly    63 LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTM---MGTQESKGIIPRLC 124

  Fly   120 NDIFNHIYAMEV-NLEFHIKVSYYEIYMDKIRDLLD--VSKVNLSVHEDKNRVPYVKGATERFVS 181
            :.:|:.|..... .|.:.::|||.|||.:|:.||||  .:|.:|.|.|.....|||.|.::..|:
  Fly   125 DQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVT 189

  Fly   182 SPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSG----KLYLVDLAGS 242
            |.:|:..::.||..:|.:|.||||..|||||:||.:.:.|...:....:||    ::.|||||||
  Fly   190 SYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGS 254

  Fly   243 EKVSKTGAEGTVLDEAKNINKSLSALGNVISALAD-------GNKTHIPYRDSKLTRILQESLGG 300
            |:..||||.|..|.|..||||||:.||.|||.|||       ||...:|||||.||.:|:::|||
  Fly   255 ERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGG 319

  Fly   301 NARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTA-------------------- 345
            |:||.:|...||::.|..||.|||.:..|||.:.|...|||:..|
  Fly   320 NSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHA 384

  Fly   346 -----------------------EEWKRRYEK-EKEKNARLKG-------------KVEKLEIEL 373
                                   :.|:.:..| |:.:|.|.:.             ||||.:..|
  Fly   385 TGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYL 449

  Fly   374 ARWRA-------------------GETVKAEEQ---------------INMEDLMEASTPNLEVE 404
            ....|                   |.|:..::.               |.:||      ..|.:|
  Fly   450 VNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIED------SGLYME 508

  Fly   405 AAQTAA--AEAALAAQRTALANMSA------------SVAVNEQARLATECERLYQQLDDKDEEI 455
            ..|.|.  ...:.|.::|.|.|...            |...|..:..|:|.:...|.:|
  Fly   509 PVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLID------ 567

  Fly   456 NQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQ 520
               ..:|   ::::|:.|  ::|     :.:|:.:||:::::    ||.|:|  |||:....|::
  Fly   568 ---YNFA---RDEIMQNE--LSN-----DPIQTAIARLERQH----EEDKQV--ALEKQRQEYER 613

  Fly   521 KSQEIDN-----------------------KNKDIDALNEE--LQQKQSVFNAASTELQQLK--- 557
            :.|::.|                       .|.....:..|  .|::..:|..:   |.|||
  Fly   614 QFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRS---LGQLKTDI 675

  Fly   558 ---------------DMSSHQKKRIT-------------------------------------EM 570
                           :|....|..:|                                     |.
  Fly   676 MRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEK 740

  Fly   571 LTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDA--SKVEEDF----------TMARLFI----- 618
            |.|.|.|:.|:.|         :.|...|.|.|.  :|.::.|          .:|.:|:
  Fly   741 LENKLIDMREMYQ---------EHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFH 796

  Fly   619 ------------------SKMKTEAKNIA------QRCSNMETQQADSNKKISEYEKDL------ 653
                              .:::.|.:.||      :.|.::.....||.   .||:..:
  Fly   797 DVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSR---DEYDDPVDPTSNQ 858

  Fly   654 ----------------------------GEYRLLISQHEARMKSLQESM----REAENKKRTL-E 685
                                        |...:::....|...:..::|    ...::...|: |
  Fly   859 ITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINE 923

  Fly   686 EQIDSLREECAKLKAAEHVSAVNAEEK-----QRAEELRSMFDSQMDELREAHTRQVSELRDEIA 745
            |.::...|....::...|.||..::.|     |:..:.||:.|      |.|...:..||..||
  Fly   924 EFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVD------RWAELSRKIELWVEI- 981

  Fly   746 AKQHEMD--------EMKDVHQKLLLAHQQMTADYEK---VRQEDAEKSSEL----QNII----- 790
               ||::        |:.:.::.|.....|:....::   ||.:..:.|..|    |:|:
  Fly   982 ---HELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIG 1043

  Fly   791 -LTNERREQARKDLKGLED-TVAKE--LQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQK 851
             :|...|.|...|....|| ||.:|  .:.|...|:...|.:|..|:|...||:..|...||..
  Fly  1044 SVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVH- 1107

  Fly   852 QKISFLE 858
            |.:|..|
  Fly  1108 QWVSLTE 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	144/355 (41%)
		KISc	12..340	CDD:214526	144/360 (40%)
		Apolipoprotein	595..744	CDD:279749	35/233 (15%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	145/361 (40%)
		KISc	6..359	CDD:214526	144/359 (40%)
		Kinesin_assoc	356..468	CDD:292801	15/111 (14%)
		FHA	446..546	CDD:238017	15/105 (14%)
		KIF1B	741..786	CDD:289208	12/53 (23%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940