DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and Cenpe

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_038959788.1	Gene:	Cenpe / 362044	RGDID:	1307115	Length:	2456	Species:	Rattus norvegicus

Alignment Length:	1094	Identity:	306/1094 - (27%)
Similarity:	501/1094 - (45%)	Gaps:	261/1094 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AEDSIKVVC-RFRPLNDSEEKAGSKFVVKFPNNVEENCI--SIAGKVYLFDKVFKPNASQEKVYN 70
            ||::...|| |.||||..||:.|....:.:  ..::|.|  |..||.:.||:||..|.:.:.||.
  Rat     2 AEEAAVAVCVRVRPLNSREEELGEASHIYW--KTDKNAIYQSDGGKSFQFDRVFHSNETTKNVYE 64

  Fly    71 EAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEF 135
            |.|..|::..:.||||||||||||:|||||||   :|.....|:|||.::|||..|.... ..||
  Rat    65 EIAVPIISSAIQGYNGTIFAYGQTASGKTHTM---MGSEDCLGVIPRAIHDIFQRIKKFP-EREF 125

  Fly   136 HIKVSYYEIYMDKIRDLL-DVSKVN-LSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRH 198
            .::|||.|||.:.|.||| :..||. |.:.||.||..||...||..|.:.|...:.:..|:.|||
  Rat   126 LLRVSYMEIYNETITDLLCNTQKVKPLIIREDINRNVYVADLTEEVVYTAEMALKWLATGEKNRH 190

  Fly   199 IAVTNMNEHSSRSHSVFLI------NVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDE 257
            ..:|.||:.|||||::|.:      ..:..|.:...|:| .|.||||||||:.::|||||..|.|
  Rat   191 YGITKMNQRSSRSHTIFRMILESREKAESSNCDGSIKVS-HLNLVDLAGSERAAQTGAEGMRLKE 254

  Fly   258 AKNINKSLSALGNVISALADGN-KTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETK 321
            ...||::|..||.||..|:||. ...|.|||||||||||.||||||:|.|:...:|||.:  ||.
  Rat   255 GCYINRNLLILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPASLD--ETL 317

  Fly   322 STLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAE- 385
            :||.|...||.:||...|||....|...:||.:|   ...||.::|::.   .:.||.|..|.:
  Rat   318 TTLQFASTAKYMKNTPYVNEVSNDEALLKRYRRE---IVDLKKQLEEVN---TKTRAQEIEKDQL 376

  Fly   386 -EQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANM---SASVAVNEQ-----ARLATEC 441
             :.::.:||::    .::.|..|.             |..|   |:|:|:.::     .|..|.|
  Rat   377 AQLLDEKDLLQ----KVQDEKIQN-------------LKRMLVTSSSIALQQELEIKKKRRVTWC 424

  Fly   442 ERLYQQLDDK---------------------------------DEEINQQSQYAEQLKEQVMEQE 473
               :.::.|.                                 :..::.:|:..:...|.:.|.|
  Rat   425 ---FGKMKDSNYVKEFKIPTNITTRTRKTSVTPLRENSLMKLGESALSWESEVFDNTLEPLAEAE 486

  Fly   474 ELIANARREYETLQSEMA--------------RIQQENESAKEEVKEVLQALE-ELAVNYDQKSQ 523
            ...|.|....|.|:||:.              ::::|||..|.::||..:..| |.....::|.|
  Rat   487 WSSATALLSEENLESELTSLNTQYNNLVLDYEQLRRENEDLKLKLKEKNELEEFEFLEQREEKDQ 551

  Fly   524 EID---------NKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLG 579
            |:.         |..|..:..|::|:      |..|::::.||:    ::.:|.|:
  Rat   552 ELQLMHEVSNLKNLIKHAEEYNQDLE------NELSSKVELLKE----KEDQIKEL--------- 597

  Fly   580 EVGQAIAPGESSIDLKMSALAGTD---ASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQAD 641
                     :..||.:.|....||   :|:..||...|...:|.:.|.|.:..:..:.:.::..:
  Rat   598 ---------QRYIDAQKSETTKTDLSYSSEATEDLKQAMRTLSDLDTVALDAKRESAFLRSENLE 653

  Fly   642 SNKKISEYEKDLGEYRLLISQHEARMKS-LQESMREAENKKRT---LEEQIDSLREECAKLKAAE 702
            ..::|:|           :|....:|:: :|...|:.|.||:.   ||:::....:|.:||.|..
  Rat   654 LKERINE-----------LSDSCKQMENGIQMYQRQLEAKKQVQADLEKELQLAFQEISKLSALV 707

  Fly   703 HVSAV--NAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAH 765
            ....:  |.|.::|..:|:...:.:::|            ::.:..:.|.:.|:|
  Rat   708 DGKGLLSNLELEKRITDLQKELNKEVEE------------KETLQKEVHLLSELK---------- 750

  Fly   766 QQMTADYEKVRQEDAEKSSELQNIILTNERR----EQARKD--LKGL--------EDTVAKEL-- 814
             .:.::.|.:|:|..|||.||  .::|.||.    |.|.||  ::||        :|..|.:|
  Rat   751 -SLPSEVETLRRELHEKSEEL--CVITTEREKLFSEMAHKDSRIQGLLEEIGNTKDDLAASQLSQ 812

  Fly   815 -------QTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQK-----QKISFLENNLDQLTKV 867
                   |.|.:|.      ::.:.|:..|.||||.....|:||     ||.:..:..|:|:.::
  Rat   813 RSSDEECQALKSLH------VELKHRQEEVLEESERVKQELSQKTQELAQKTAEGQEMLNQMEEL 871

  Fly   868 HKQLVRDNADLRC---ELPKLEKRLRCTMERVKAL---ETALKEAKEGAMRDR------------ 914
            .::|.|.::.|:.   |...|.::|:.|:|.|:||   :..||:.:|....:|
  Rat   872 REKLERRDSSLQSAEKEKNLLTEKLQQTLEEVRALTQEKNDLKQLQESLQTERDQLRSDIQDTVN 936

  Fly   915 ----------------KRYQYEVDRIKEAVRQK---HL---GRRGPQAQIAKPI 946
                            |::|..::.:|....::   ||   ||.|...::.:.:
  Rat   937 MNIDTQEQLLNALESLKQHQETINMLKMKATEEMSDHLPIKGREGSSDEVEQKL 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	151/334 (45%)
		KISc	12..340	CDD:214526	152/339 (45%)
		Apolipoprotein	595..744	CDD:279749	30/157 (19%)
Cenpe	XP_038959788.1	KISc_CENP_E	6..329	CDD:276825	150/331 (45%)
		Smc	<334..1057	CDD:224117	152/753 (20%)
		Smc	787..1603	CDD:224117	46/210 (22%)
		Smc	1320..2167	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910