Protein Alignment Khc and klp-20

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_497178.1
• Gene: klp-20 / 3565057
• WormBaseID: WBGene00002230
• Length: 646
• Species: Caenorhabditis elegans
• Alignment Length: 708
• Identity: 238/708 - (33%)
• Similarity: 354/708 - (50%)
• Gaps: 116/708 - (16%)

  Fly    11 DSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAG-------KVYLFDKVFKPNASQEKV 68
            :.:|||.|.||::.:|:..|.|..|..  |.||..::|..       :.:.||.||.||..|..|
 Worm     5 EKVKVVVRCRPISTTEKLQGHKIAVTC--NDEEKAVNIKSLSQEDPPRTFYFDAVFSPNTDQMTV 67

  Fly    69 YNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNL 133
            ||.||:.||.:||.||||||||||||.:|||.||.|.:.....:||||.....||:||...:.:.
 Worm    68 YNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMRGIIPNSFAHIFDHIAKCQHDT 132

  Fly   134 EFHIKVSYYEIYMDKIRDLLDVS-KVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNR 197
            .|.::|||.|||.::|||||... ..||.:.|..:...||:..:...|.:...:..::|.|..||
 Worm   133 TFLVRVSYLEIYNEEIRDLLSKDHNGNLEIKERPDVGVYVRNLSNPTVENASKMQALMEFGSKNR 197

  Fly   198 HIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNIN 262
            .:..|.||..|||||::|.:.:  |:..|.....|||.||||||||:.|||||:|..|.||..||
 Worm   198 KVGATAMNLESSRSHAMFTVTI--ESCRNGLVTQGKLQLVDLAGSERQSKTGAQGERLKEAAKIN 260

  Fly   263 KSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFG 327
            .|||.||||||:|.||..||||||:|||||:||:|||||::|.::....||::|..||.|||.:.
 Worm   261 LSLSTLGNVISSLVDGKSTHIPYRNSKLTRLLQDSLGGNSKTVMIANVGPATYNYDETLSTLRYA 325

  Fly   328 RRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMED 392
            .|||.::||..:||:              .|:|:|: |.: ||||..|....|....::: |.|:
 Worm   326 NRAKNIQNVAKINED--------------PKDAQLR-KFQ-LEIEALRKILDEENPGDDE-NQEE 373

  Fly   393 LMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQ 457
            ..||.....|||          :..:|..|.....| |||::     |..||.:::.:.:.|:.:
 Worm   374 AWEAKMQEREVE----------MEKKRKILEERVNS-AVNDE-----ETHRLVKEMMENEAELKK 422

  Fly   458 -QSQY-----------------AEQLKEQVMEQEELIANARREYETLQSEMARIQ---QENESAK 501
             :|::                 .|.|.|:|.||.:|:....:|.|..:.:.|.::   :|..:.|
 Worm   423 ARSEHEKLRSKLEKIEKKLIVGGENLLEKVEEQAKLLEVNNKELEQSKFQEAHLRTQLEERTAVK 487

  Fly   502 EEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKR 566
            .|::|...:|:|.|....:|.:::.|:.||..|                    :|||:....:::
 Worm   488 VEIEERYSSLQEEAFVKSKKIKKVSNELKDARA--------------------ELKDLEEDHQRQ 532

  Fly   567 ITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEE--DFTMARLFISKMKTEAKNIA 629
            :..||.::.:...|:...||..:..|.::...|.....|..||  |:            :.|.||
 Worm   533 VEAMLDDIRQLRKELLLNIAIIDEYIPVEHVELIEKYVSWSEEHGDW------------QLKAIA 585

  Fly   630 QRCSNMETQQADSNKKIS----------EYEKDLG----EYRLLIS--QHEARMKSLQ 671
            ...:||......:.|:.|          .|..|||    |:|...|  :|.|.::..|
 Worm   586 YTGNNMRASAPPAKKEFSNNNQTVPMYYSYRADLGASTAEHRPRTSSKKHRASIRLQQ 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	153/329 (47%)
		Smc	<341..>807	CDD:440809	82/370 (22%)
		Khc_CBD_cc	856..925	CDD:467880
klp-20	NP_497178.1	Motor_domain	5..331	CDD:473979	153/329 (47%)
		Smc	<325..>556	CDD:440809	65/283 (23%)