Protein Alignment Khc and CG5004

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Alignment Length: 1014
• Identity: 195/1014 - (19%)
• Similarity: 339/1014 - (33%)
• Gaps: 347/1014 - (34%)

  Fly     4 EREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKV 68
            |.|.|...|..:|....|..|   ..|.|: ..|..|:.||                 :.:::::
  Fly   172 ELECPKVFSSDLVTVNMPAKD---VLGQKY-ASFARNLAEN-----------------HRNEKQL 215

  Fly    69 YNEAAKSIVTDVLAGY-----NGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFN---- 124
            .|:.||.:.::  .||     |..|:.       :.|..:   .....|.::.::.||.::
  Fly   216 NNQYAKGVGSN--GGYWNVPSNAAIYK-------EQHQQQ---HQQAPQDLLTKVNNDRYDRYPK 268

  Fly   125 ----HIYAM-----EVN----------------LEFHIKV-SYYEIYMDKIRDLLDVS------- 156
                .||:|     ::|                ||..:|: :.|....:.:....:||
  Fly   269 AGGLQIYSMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITS 333

  Fly   157 --------KVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHS 213
                    |.|.|:..|||:.|:.:.|.   |:|..::                ::...||...:
  Fly   334 SPIVQNRIKTNGSLPRDKNKSPFPQQAG---VASSANI----------------SLLSSSSGYEN 379

  Fly   214 VFLINVKQENLENQKKLSGKLYLVDLAG----SEKVSKTGAEGTVLDEA--KNINKSLSALGNVI 272
            |.|:.      .|:.:::|::::...||    |..||......|....|  :|:|::.||
  Fly   380 VRLLG------PNRVEINGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSA----- 433

  Fly   273 SALADGNKTHIPYRDSKLTRILQESLG-------GNARTTIVICCSPASFNESETKST------- 323
               ..|.| ::|  .|..|:|....:.       |||   ..:..||.....|...||
  Fly   434 ---TTGGK-YVP--QSPRTKIRTNCMSPKKDVSFGNA---FALAISPPPLASSAVVSTSKPIPIP 489

  Fly   324 ------------------------LDFGRRAKTV----------KNVVCVNEELTAEEWKRRYEK 354
                                    ..|.|:.:.:          ||:..:...|.:.|.:.:..|
  Fly   490 SMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQLDRMVPAKRSNKNINNLTLNLQSVESQTQSPK 554

  Fly   355 --------------EKEKNARLKGKVEKLEIELARWRAGETVKA-EEQINMEDLMEASTPNLEVE 404
                          |:.:...|..:.::|:.|||.......::. |.::..:.|..:::|.|:::
  Fly   555 PSRKPAPAPRSIHLEQRQRRELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQ 619

  Fly   405 AAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQV 469
            |.|.....  |.|||.|...|..    |:||:|....|....||......:.|:...| .|||::
  Fly   620 ALQNRVCR--LEAQRNATRVMEE----NQQAKLKQSIEIKQDQLKKLRAMLKQKPNNA-CLKEEL 677

  Fly   470 MEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDA 534
            ....|.:.:.|:.:|.|:.:....:.|:.::.||.|...|.|                      .
  Fly   678 QLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRL----------------------M 720

  Fly   535 LNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSAL 599
            |..||         |:..:|                   :..|..|.|...:||.:..:|....:
  Fly   721 LEAEL---------AALRIQ-------------------IGPDEEEPGSPTSPGSTGSNLVNGVM 757

  Fly   600 AGTDASKVEEDFTMARLFISKMKTE----AKNIAQRC---SNMETQQADSNKKISEYEKDLG--- 654
            :       :..|..|.|...|.:.:    :|::.:..   ..:|...:...:...:..:||.
  Fly   758 S-------QSLFGSAELLCPKRRNQEDLMSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGS 815

  Fly   655 ----EYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRA 715
                .:.|          |||....|....:|.:..| |.:...|.....|...::..|..|
  Fly   816 CEQISFNL----------SLQGDRFEVNPLERRVPSQ-DDIDRSCKVANDAPISASQGASTK--- 866

  Fly   716 EELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQ-QMTADYEKVRQED 779
                 :|||.|:..|                           ::|||||.| ....::|:.:..|
  Fly   867 -----IFDSIMEIER---------------------------NRKLLLAQQGHQVIEHERQKMYD 899

  Fly   780 AEKSS----ELQNIILTNERREQAR---------KDLKGLEDTVAKELQTLHNLRKLFVQDLQQR 831
            .:|.|    ..|.::.|.:..||.|         ||.|..|.|   |||.|:......|.|..|:
  Fly   900 LKKKSHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKT---ELQKLNQKPGEPVDDQVQK 961

  Fly   832 I----RKNVVNEES-----------EEDGGSLAQKQKIS 855
            |    ..||.|.:|           ...||:..|:|:.|
  Fly   962 IAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHS 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	74/416 (18%)
		Smc	<341..>807	CDD:440809	97/508 (19%)
		Khc_CBD_cc	856..925	CDD:467880	195/1014 (19%)
CG5004	NP_573195.1	FHA_PHLB1	1..122	CDD:438765
		SMC_N	<570..730	CDD:481474	43/197 (22%)
		Caldesmon	<664..801	CDD:460421	32/194 (16%)
		PH-like	1142..1242	CDD:473070