DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and CG5004

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster

Alignment Length:	1014	Identity:	196/1014 - (19%)
Similarity:	337/1014 - (33%)	Gaps:	347/1014 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EREIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKV 68
            |.|.|...|..:|....|..|   ..|.|: ..|..|:.||                 :.:::::
  Fly   172 ELECPKVFSSDLVTVNMPAKD---VLGQKY-ASFARNLAEN-----------------HRNEKQL 215

  Fly    69 YNEAAKSIVTDVLAGYNGTIFAYGQTSSG-----KTHTMEGVIGDSVKQGIIPRIVNDIFN---- 124
            .|:.||.:      |.||   .|....|.     :.|..:   .....|.::.::.||.::
  Fly   216 NNQYAKGV------GSNG---GYWNVPSNAAIYKEQHQQQ---HQQAPQDLLTKVNNDRYDRYPK 268

  Fly   125 ----HIYAM-----EVN----------------LEFHIKV-SYYEIYMDKIRDLLDVS------- 156
                .||:|     ::|                ||..:|: :.|....:.:....:||
  Fly   269 AGGLQIYSMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITS 333

  Fly   157 --------KVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHS 213
                    |.|.|:..|||:.|:.:.|.   |:|..::                ::...||...:
  Fly   334 SPIVQNRIKTNGSLPRDKNKSPFPQQAG---VASSANI----------------SLLSSSSGYEN 379

  Fly   214 VFLINVKQENLENQKKLSGKLYLVDLAG----SEKVSKTGAEGTVLDEA--KNINKSLSALGNVI 272
            |.|:.      .|:.:::|::::...||    |..||......|....|  :|:|::.||
  Fly   380 VRLLG------PNRVEINGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSA----- 433

  Fly   273 SALADGNKTHIPYRDSKLTRILQESLG-------GNARTTIVICCSPASFNESETKST------- 323
               ..|.| ::|  .|..|:|....:.       |||   ..:..||.....|...||
  Fly   434 ---TTGGK-YVP--QSPRTKIRTNCMSPKKDVSFGNA---FALAISPPPLASSAVVSTSKPIPIP 489

  Fly   324 ------------------------LDFGRRAKTV----------KNVVCVNEELTAEEWKRRYEK 354
                                    ..|.|:.:.:          ||:..:...|.:.|.:.:..|
  Fly   490 SMVKPPLAPKPPAPNQQRDYEQLFKSFERKQQQLDRMVPAKRSNKNINNLTLNLQSVESQTQSPK 554

  Fly   355 --------------EKEKNARLKGKVEKLEIELARWRAGETVKA-EEQINMEDLMEASTPNLEVE 404
                          |:.:...|..:.::|:.|||.......::. |.::..:.|..:::|.|:::
  Fly   555 PSRKPAPAPRSIHLEQRQRRELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQ 619

  Fly   405 AAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQV 469
            |.|.....  |.|||.|...|..    |:||:|....|....||......:.|:...| .|||::
  Fly   620 ALQNRVCR--LEAQRNATRVMEE----NQQAKLKQSIEIKQDQLKKLRAMLKQKPNNA-CLKEEL 677

  Fly   470 MEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDA 534
            ....|.:.:.|:.:|.|:.:....:.|:.::.||.|...|.|                      .
  Fly   678 QLVCESLESDRKTFEDLEFQYFEEESEHHASHEEFKRQEQRL----------------------M 720

  Fly   535 LNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSAL 599
            |..||         |:..:|                   :..|..|.|...:||.:..:|....:
  Fly   721 LEAEL---------AALRIQ-------------------IGPDEEEPGSPTSPGSTGSNLVNGVM 757

  Fly   600 AGTDASKVEEDFTMARLFISKMKTE----AKNIAQRC---SNMETQQADSNKKISEYEKDLG--- 654
            :       :..|..|.|...|.:.:    :|::.:..   ..:|...:...:...:..:||.
  Fly   758 S-------QSLFGSAELLCPKRRNQEDLMSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGS 815

  Fly   655 ----EYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRA 715
                .:.|          |||....|....:|.:..| |.:...|.....|...::..|..|
  Fly   816 CEQISFNL----------SLQGDRFEVNPLERRVPSQ-DDIDRSCKVANDAPISASQGASTK--- 866

  Fly   716 EELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQ-QMTADYEKVRQED 779
                 :|||.|:..|                           ::|||||.| ....::|:.:..|
  Fly   867 -----IFDSIMEIER---------------------------NRKLLLAQQGHQVIEHERQKMYD 899

  Fly   780 AEKSS----ELQNIILTNERREQAR---------KDLKGLEDTVAKELQTLHNLRKLFVQDLQQR 831
            .:|.|    ..|.::.|.:..||.|         ||.|..|.|   |||.|:......|.|..|:
  Fly   900 LKKKSHDEARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKT---ELQKLNQKPGEPVDDQVQK 961

  Fly   832 I----RKNVVNEES-----------EEDGGSLAQKQKIS 855
            |    ..||.|.:|           ...||:..|:|:.|
  Fly   962 IAGDKENNVQNRKSTGSSPTTTTTTTTGGGTTPQQQRHS 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	75/416 (18%)
		KISc	12..340	CDD:214526	77/431 (18%)
		Apolipoprotein	595..744	CDD:279749	25/162 (15%)
CG5004	NP_573195.1	FHA	41..104	CDD:278899
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930