Protein Alignment Khc and Kif21a

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: XP_038934809.1
• Gene: Kif21a / 300158
• RGDID: 1305126
• Length: 1677
• Species: Rattus norvegicus
• Alignment Length: 1017
• Identity: 267/1017 - (26%)
• Similarity: 458/1017 - (45%)
• Gaps: 224/1017 - (22%)

  Fly    10 EDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIA----------GKVYLFDKVFKPNAS 64
            |.|::|..|.||....|:..|...           |.|:.          .|.:.||.||..::.
  Rat     7 ESSVRVAVRIRPQLAKEKIEGCHI-----------CTSVTPGEPQVFLGKDKAFTFDYVFDIDSQ 60

  Fly    65 QEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSV---KQGIIPRIVNDIFNHI 126
            ||::|.:..:.::.....|||.|:||||||.:|||:||......::   :||||.|.|..:|..|
  Rat    61 QEQIYTQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGIISRAVKHLFKSI 125

  Fly   127 YAMEVNL--------EFHIKVSYYEIYMDKIRDLLDVS--------KVNLSVHEDKNRVPYVKGA 175
            ...:.:.        ||.:...:.|:|.:::.||.|.:        |.|:.:|||.....|..|.
  Rat   126 EEKKTSAIKNGVPPPEFKVNAQFLELYNEEVLDLFDTTRDIDAKNKKSNIRIHEDSTGGIYTVGV 190

  Fly   176 TERFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQ---------ENLENQK--- 228
            |.|.|::..::.:.::.|..:|..|.|.||..|||||::|.|:|.|         ||:.:.|
  Rat   191 TTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQTDAENVTDNKMVS 255

  Fly   229 ---------KLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNK--TH 282
                     .|:.|.:.|||||||::.:|||.|....|..:||..|.|||||||||.|.:|  ||
  Rat   256 ESPQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRATH 320

  Fly   283 IPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEE 347
            :|||||||||:||:|||||::|.::.|.||:..:..||.:||.:..||:.:||.|.||::..::
  Rat   321 VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQ- 384

  Fly   348 WKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQI-NMED------LMEASTPNLEVEA 405
                     :.|| |:.::.:|::||..::.|:.:..||.: ::.|      :::....||.|..
  Rat   385 ---------QINA-LRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRI 439

  Fly   406 AQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEI-NQQSQY---AEQLK 466
            ........||.|:.|.|        |:|||      .::..:..:.:||| |....|   .|.|:
  Rat   440 KAMQETVDALRARITQL--------VSEQA------NQVLARAGEGNEEISNMIHSYIKEIEDLR 490

  Fly   467 EQVMEQEELIANARR-------------------------EYETLQ-SEMARIQQENESAKEE-V 504
            .:::|.|.:..|.|:                         :.||:: .::|:...|....||: .
  Rat   491 AKLLESEAVNENLRKSLTRATARSPFFSASSAFSSTILSSDKETIEIIDLAKKDLEKLKRKEKRK 555

  Fly   505 KEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTE--LQQLKDMSSHQKKRI 567
            |:.||.|||.:    ::.:.:..|..:.|. ::|.::::.|....|:|  :.:.::.|.|:.:..
  Rat   556 KKRLQKLEESS----REERSVAGKENNADP-DQEKKEEKGVSEKESSEVDVDENQEASDHEDEED 615

  Fly   568 TEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRC 632
            .|.......|:        .||.|          :|.|..|.|             |..|.....
  Rat   616 EEEEDEEEDDI--------EGEES----------SDESDSESD-------------EKANYQADL 649

  Fly   633 SNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMREAE-NKKRTLEE--QIDSLREE 694
            :|:..:.|...|.|.|.|......:.|..|:|.::..||..:|:.: .:.:.|:.  .::|..||
  Rat   650 ANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGSVESYSEE 714

  Fly   695 CAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQ 759
            .||....|:...::|..|    ||:.:..:|.:..|  ..:..|:...::...|.::.|||....
  Rat   715 KAKKVKCEYEKKLHAMNK----ELQRLQTAQKEHAR--LLKNQSQYEKQLKKLQQDVTEMKKTKV 773

  Fly   760 KLLLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLF 824
            :|:   :||..:.||.|..::.::.|:..:     :::|.::|               |.||.|
  Rat   774 RLM---KQMKEEQEKARLTESRRNREIAQL-----KKDQRKRD---------------HQLRLL- 814

  Fly   825 VQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLT-KVHKQLVRD------------NA 876
              :.|:|.::.|:..::||......|.:.:|      |::. ||.::|...            :.
  Rat   815 --EAQKRNQEVVLRRKTEEVTALRRQVRPMS------DKVAGKVTRKLSSSESPTPDAGSSVTSG 871

  Fly   877 DLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQ 918
            :.....|..::::|..:.||:||.|.....      .|||||
  Rat   872 EADASRPGTQQKMRIPVARVQALPTPTTNG------TRKRYQ 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	132/374 (35%)
		Smc	<341..>807	CDD:440809	103/508 (20%)
		Khc_CBD_cc	856..925	CDD:467880	16/76 (21%)
Kif21a	XP_038934809.1	KISc_KIF4	8..372	CDD:276823	131/374 (35%)
		SCP-1	<389..1040	CDD:114219	128/613 (21%)
		EnvC	642..>853	CDD:443969	54/248 (22%)
		Rcc_KIF21A	938..1019	CDD:410204
		WD40	1342..1655	CDD:238121
		WD40 repeat	1393..1452	CDD:293791
		WD40 repeat	1458..1493	CDD:293791
		WD40 repeat	1498..1542	CDD:293791
		WD40 repeat	1550..1583	CDD:293791
		WD40 repeat	1590..1626	CDD:293791