DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and Kif3b

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001099999.1	Gene:	Kif3b / 296284	RGDID:	1306815	Length:	747	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	258/788 - (32%)
Similarity:	387/788 - (49%)	Gaps:	143/788 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EIPAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAG---------KVYLFDKVFKP 61
            ::.:.:|::||.|.||:|..|:.|....||..  :|:...:|:..         |.:.||.|:..
  Rat     3 KLKSSESVRVVVRCRPMNGKEKAAAYDKVVDV--DVKLGQVSVKNPKGTSHEMPKTFTFDAVYDW 65

  Fly    62 NASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHI 126
            ||.|.::|:|..:.:|..||.|:||||||||||.:|||:|||||.||..|:|:||...:.||.||
  Rat    66 NAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGVRGDPEKRGVIPNSFDHIFTHI 130

  Fly   127 YAMEVNLEFHIKVSYYEIYMDKIRDLL--DVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEV 189
             :...|.::.::.||.|||.::|||||  |.:| .|.:.|..:...|||..:.....|.:::..|
  Rat   131 -SRSQNQQYLVRASYLEIYQEEIRDLLSKDQTK-RLELKERPDTGVYVKDLSSFVTKSVKEIEHV 193

  Fly   190 IEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENL----ENQKKLSGKLYLVDLAGSEKVSKTGA 250
            :..|..||.:..|||||||||||::|:|.|:...:    ||..:: |||.||||||||:.:||||
  Rat   194 MNVGNQNRSVGATNMNEHSSRSHAIFVITVECSEVGLDGENHIRV-GKLNLVDLAGSERQAKTGA 257

  Fly   251 EGTVLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASF 315
            :|..|.||..||.||||||||||||.||..||||||||||||:||:||||||:|.:|....|||:
  Rat   258 QGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVANVGPASY 322

  Fly   316 NESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWR--- 377
            |..||.:||.:..|||.:||...|||: ..:...|.::   |:.||||.::||..|...:.|
  Rat   323 NVEETLTTLRYANRAKNIKNKPRVNED-PKDALLREFQ---EEIARLKAQLEKRSIGRRKRREKR 383

  Fly   378 --------AGETVK------AEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSAS 428
                    .||..:      .||..:.:|........||:|              :.|:
  Rat   384 REGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEKLEIE--------------KRAI------ 428

  Fly   429 VAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVM------------------EQEEL 475
              |.:.:.:|.|..||.::.:.|.|::.::...||.|..::.                  ||:::
  Rat   429 --VEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKNIVDHTNEQQKI 491

  Fly   476 IANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQ 540
            :...|:|....:.....|||:.||..||..       ||...|....||:|.|.|.:..|..:||
  Rat   492 LEQKRQEIAEQKRREREIQQQMESRDEETL-------ELKETYTSLQQEVDIKTKKLKKLFSKLQ 549

  Fly   541 QKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDAS 605
                   |...|:..|::....:::.:.:....|.|:| ::...|.  |:.|.|:
  Rat   550 -------AVKAEIHDLQEEHIKERQELEQTQNELTREL-KLKHLII--ENFIPLE---------- 594

  Fly   606 KVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSL 670
              |::..|.|.|....:...|  ....:.:|.||. ..:.:|.    :| |:..:||| |||..:
  Rat   595 --EKNKIMNRSFFDDEEDHWK--LHPITRLENQQM-MKRPVSA----VG-YKRPLSQH-ARMSMM 648

  Fly   671 --QESMREAEN--------KKRT------------LEEQIDSL--REECAKLKAAEHVSAVNAEE 711
              .|....|||        ..||            ::..:|:.  .|:..::.|:...|..|.:.
  Rat   649 IRPEPRYRAENIMLLELDMPSRTTRDYEGPAISPKVQAALDAALQDEDEIQVDASSFESTANRKA 713

  Fly   712 KQRAEELR 719
            |.|.:..|
  Rat   714 KARPKSGR 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	161/337 (48%)
		KISc	12..340	CDD:214526	163/342 (48%)
		Apolipoprotein	595..744	CDD:279749	31/149 (21%)
Kif3b	NP_001099999.1	KISc_KIF3	8..340	CDD:276822	161/336 (48%)
Kif3b	NP_001099999.1	Smc	<352..>614	CDD:224117	66/317 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910