Protein Alignment Khc and Kif21b

DIOPT Version :9

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: XP_006249915.1
• Gene: Kif21b / 289397
• RGDID: 1306206
• Length: 1635
• Species: Rattus norvegicus
• Alignment Length: 1117
• Identity: 283/1117 - (25%)
• Similarity: 476/1117 - (42%)
• Gaps: 282/1117 - (25%)

  Fly    13 IKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIA----------GKVYLFDKVFKPNASQEK 67
            :||..|.||....|:..|...           |.|:.          .|.:.:|.||..:..||:
  Rat     9 VKVAVRIRPQLSKEKIEGCHI-----------CTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQ 62

  Fly    68 VYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSV----KQGIIPRIVNDIFNHI-- 126
            :|:.....::.....|||.|:.|||||.:|||:|| |...|:|    :||||||.:..:|..|
  Rat    63 IYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTM-GTGFDTVTSEEEQGIIPRAIAHLFRGIDE 126

  Fly   127 ---YAMEVNL---EFHIKVSYYEIYMDKIRDLLDVS--------KVNLSVHEDKNRVPYVKGATE 177
               .|.|..:   ||.:...:.|:|.::|.||.|.:        :.|:.:|||.|...|..|.|.
  Rat   127 RKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTS 191

  Fly   178 RFVSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINV------KQENLENQ--------- 227
            |.::|.|::.:.:::|..:|..|.|.||..|||||::|.|::      .|.:|.|:
  Rat   192 RLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGT 256

  Fly   228 -------KKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNK--THI 283
                   :.|:.|.:.|||||||::.:|||.|....|..:||..|.|||||||||.|.:|  .|:
  Rat   257 APTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHV 321

  Fly   284 PYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEW 348
            |||||||||:||:|||||::|.::.|.||:..:..||.:||.:..||:.:||.|.||::.|:::
  Rat   322 PYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQ- 385

  Fly   349 KRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEE------QINMEDLM---EASTPNLEVE 404
                      .:.|:.::.:|::||..::||:.|..|:      .:..|:.|   |.....|.|:
  Rat   386 ----------ISALRAEIARLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVK 440

  Fly   405 AAQTA------------AAEAALAAQRTALAN--------------------MSASVAVNEQARL 437
            |.|.|            :.||.|...:....|                    :..|.|:||..|.
  Rat   441 AMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRR 505

  Fly   438 A---TECERLY----------------QQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREY 483
            :   ......|                ..::|..|.|.:..|..|:||::.:.|....:..:..:
  Rat   506 SLSRASARNPYSLGASPAGPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSSPEKEAF 570

  Fly   484 ETLQSEMARIQQEN-----------------ESAKEEVKEVLQALEELAVNYDQKSQEID-NKNK 530
            :    :.|::||||                 ||..||.::.....||..|:.|...:|.: |...
  Rat   571 K----KRAKLQQENSEETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDSDPEEKEVNFQA 631

  Fly   531 DIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLK 595
            |:..|..|::.||.:.:......::|:.: .||.:....:|.|.:||.......:....|:
  Rat   632 DLADLTCEIEIKQKLIDELENSQRRLQTL-KHQYEEKLILLQNKIRDTQLERDRVLQNLST---- 691

  Fly   596 MSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLI 660
            |.......|:|::.|:       .|...|.....|:....:.:.|...|..|.||::|.:.:..:
  Rat   692 MECYTEEKANKIKADY-------EKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQTEV 749

  Fly   661 SQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAE-----HVSAVNAEEKQRAEELRS 720
            ::.:....:|.:.|||.:.::|.:|.:   ...|.|:||..:     .:.|:.::::|:...||
  Rat   750 AEMKKAKVALMKQMREEQQRRRLVETK---RNREIAQLKKEQRRQEFQIRALESQKRQQEIVLR- 810

  Fly   721 MFDSQMDELREAHTRQVSELR-----------DEIAAKQHEMDEMKDV----------------- 757
                       ..|::||.||           ..:..|...||...:|
  Rat   811 -----------RKTQEVSALRRLAKPMSERVAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVS 864

  Fly   758 ------HQKL---LLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLE----DT 809
                  ::|:   |..|...|.:..:..::..:|....|:.      .:.||...:.||    |.
  Rat   865 SIVRQWNRKINHFLGDHPTATVNGARPARKKFQKKGASQSF------SKAARLKWQSLERRIIDI 923

  Fly   810 VAKELQTLHNL-----------RKLF-VQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLD 862
            |.:.: |:.||           .:|| :|:..:|.|:.:..|..||:.|.....::|..|..|:|
  Rat   924 VMQRM-TIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANID 987

  Fly   863 --------------QLTKVHKQLVRDNADL-----RCELPK----LEKRLRCTMERVKALETALK 904
                          ||.:..::|  |:.|.     .|.|.:    |:..|:.:::  |.|:.|.|
  Rat   988 YINDSITDCQATIMQLEETKEEL--DSTDTSVVISSCSLAEARLLLDNFLKASID--KGLQVAQK 1048

  Fly   905 EAK----EGAMR 912
            ||:    ||.:|
  Rat  1049 EAQIRLLEGRLR 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	133/373 (36%)
		KISc	12..340	CDD:214526	136/380 (36%)
		Apolipoprotein	595..744	CDD:279749	32/164 (20%)
Kif21b	XP_006249915.1	KISc_KIF4	7..372	CDD:276823	133/374 (36%)
		KISc	9..378	CDD:214526	136/380 (36%)
		PKK	657..791	CDD:289257	31/148 (21%)
		JAKMIP_CC3	675..803	CDD:292653	27/141 (19%)
		Prefoldin	961..1097	CDD:298833	26/104 (25%)
		WD40	1303..1611	CDD:238121
		WD40	1304..>1612	CDD:225201
		WD40 repeat	1310..1344	CDD:293791
		WD40 repeat	1349..1385	CDD:293791
		WD40 repeat	1405..1448	CDD:293791
		WD40 repeat	1454..1498	CDD:293791
		WD40 repeat	1507..1539	CDD:293791
		WD40 repeat	1546..1570	CDD:293791

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910