DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc and tea2

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_596620.1	Gene:	tea2 / 2539857	PomBaseID:	SPBC1604.20c	Length:	628	Species:	Schizosaccharomyces pombe

Alignment Length:	511	Identity:	157/511 - (30%)
Similarity:	250/511 - (48%)	Gaps:	69/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YLFDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPR 117
            |||:.||...:....:|..:.||:|.:|.:||||.:||||.|.:|||::|:|...:   .||||.
pombe   179 YLFNNVFGMESKNYDIYKRSVKSVVRNVFSGYNGIVFAYGMTGTGKTYSMQGTENE---PGIIPL 240

  Fly   118 IVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSS 182
            .:||:|..:.....:..|.|::||.|||.::||||:..|.....:.|:.:....|...|...|:|
pombe   241 AMNDLFEMVENNSDDDTFQIRISYLEIYNERIRDLIGNSDEEPRIRENASGEVNVTPLTRVLVTS 305

  Fly   183 PEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSK 247
            ||:|.:|||:..:.|..|.|:.|.:|||||::..:.:.:.|..........|.||||||||:.|
pombe   306 PEEVSQVIEQCNAIRKTAATDFNTYSSRSHAILQVFLIRNNPTAHTSQISSLSLVDLAGSERAS- 369

  Fly   248 TGAEGTVLDEAKNINKSLSALGNVISALA-------DGNKTHIPYRDSKLTRILQESLGGNARTT 305
              |......|...|||||..||.|||.|:       ..|..|||||:|||||:||:||.|.::.:
pombe   370 --AHHERRKEGAFINKSLLTLGTVISRLSAAANPSLTSNSGHIPYRESKLTRLLQQSLSGQSQIS 432

  Fly   306 IVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLE 370
            ::...|..|.:..||.:||.|..||:.:                       .::.|....|..::
pombe   433 LLATISIESNHTMETTNTLKFASRAQNL-----------------------PQDIRQAEAVTNVQ 474

  Fly   371 IELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQA 435
            .|||...:.....|:|......|::..|.:||......|..||. .:|.||::          :|
pombe   475 AELASLHSALEKNAQEVEYYASLVKQLTSDLEERDTYIAMLEAE-RSQGTAIS----------RA 528

  Fly   436 RLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESA 500
            ||     |:.:.|.|.:.||       ..|::::.::|::|...|  |...|.::|..   |:|.
pombe   529 RL-----RMEELLSDHNFEI-------ADLRDELQDKEQIIYALR--YAQKQRDIADF---NQSL 576

  Fly   501 KEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQL 556
            .:...::|:  :.:.......|.:..|:.| .:.|.::  |:||..::.:.|.|.|
pombe   577 AKFPHKILK--KNVTRGSRSSSDQFSNETK-TEILPDD--QQQSKKDSVTQETQLL 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	112/286 (39%)
		KISc	12..340	CDD:214526	112/293 (38%)
		Apolipoprotein	595..744	CDD:279749
tea2	NP_596620.1	Motor_domain	133..460	CDD:277568	112/286 (39%)
tea2	NP_596620.1	Kinesin	138..459	CDD:278646	112/285 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910