Protein Alignment Khc and Cenpe

DIOPT Version :9

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_776123.3
• Gene: Cenpe / 229841
• MGIID: 1098230
• Length: 2471
• Species: Mus musculus
• Alignment Length: 1092
• Identity: 308/1092 - (28%)
• Similarity: 498/1092 - (45%)
• Gaps: 209/1092 - (19%)

  Fly    10 EDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCI--SIAGKVYLFDKVFKPNASQEKVYNEA 72
            |.|:.|..|.||||..||:.|....:.:  ..::|.|  |..||.:.||:||..|.:.:.||.|.
Mouse     4 EASVAVCVRVRPLNSREEELGEATHIYW--KTDKNAIYQSDGGKSFQFDRVFDSNETTKNVYEEI 66

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHI 137
            |..|::..:.||||||||||||:|||||||   :|.....|:|||.::|||..|.... ..||.:
Mouse    67 AVPIISSAIQGYNGTIFAYGQTASGKTHTM---MGSEDCLGVIPRAIHDIFQRIKKFP-EREFLL 127

  Fly   138 KVSYYEIYMDKIRDLL-DVSKVN-LSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIA 200
            :|||.|||.:.|.||| :..|:. |.:.||.||..||...||..|.:.|...:.:..|:.|||..
Mouse   128 RVSYMEIYNETITDLLCNAQKMKPLIIREDTNRTVYVSDLTEEVVYTAEMALKWLATGEKNRHYG 192

  Fly   201 VTNMNEHSSRSHSVFLI------NVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAK 259
            :|.||:.|||||::|.:      ..:..|.:...|:| .|.||||||||:.::|||||..|.|..
Mouse   193 ITKMNQRSSRSHTIFRMILESREKAEPSNCDGSVKVS-HLNLVDLAGSERAAQTGAEGVRLKEGC 256

  Fly   260 NINKSLSALGNVISALADGN-KTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKST 323
            .||::|..||.||..|:||. ...|.|||||||||||.||||||:|.|:...:|||.:  ||.:|
Mouse   257 FINRNLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPASLD--ETLTT 319

  Fly   324 LDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVK----- 383
            |.|...||.:||...|||....|...:||.:|   .|.|:.::|::.   .:.||.|..|
Mouse   320 LQFASTAKYMKNTPYVNEVSNDEALLKRYRRE---IADLRKQLEEVN---TKTRAQEMEKDQLAQ 378

  Fly   384 -AEEQINMEDLMEASTPNLE--VEAAQTAAAEAALAAQR-----------------------TAL 422
             .:|:..::.:.:....||:  :..:.:.|.:..|..:|                       |::
Mouse   379 LLDEKDLLQKVQDEKINNLKRMLVTSSSIALQQELEIKRKRRVTWCYGKMKDSNYEKEFKVPTSI 443

  Fly   423 ANMSASVAVNE----------QARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIA 477
            .......:|..          ::..::|.|.|...|:...|.  :.|.....|.|:.:|.|....
Mouse   444 TTRKRKTSVTSLRENSLMKFGESAASSEFEMLNNTLESLAEV--EWSSATTLLSEENVESELNSL 506

  Fly   478 NARREYETLQSEMARIQQENESAKEEVKEVLQALE-ELAVNYDQKSQEIDNKNKDIDALNEELQQ 541
            ||  :|..|..:..::::|||..|.::||..:..| ||....:::.||:.        |..|:..
Mouse   507 NA--QYNDLVLDYEQLRRENEDLKLKLKEKNELEEFELLEQKEERDQEMQ--------LMHEVSN 561

  Fly   542 KQSVFNAASTELQQLK-DMSSHQK--KRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTD 603
            .:::...|....|.|: |:||..|  |...|.:.||        |.....:.|..:|:.....:|
Mouse   562 LKNLIKHAEEYNQDLENDLSSKVKLLKEKEEQIKNL--------QEYIDAQKSEKMKIDLSYTSD 618

  Fly   604 ASKVEEDFTMARLFISKMKTEAKNIAQ-----RCSNMETQQ-----ADSNKK----ISEYEKDL- 653
            |:   ||...|...:|.:.|.|.:..:     |..|:|.::     :||.|:    |..|::.|
Mouse   619 AT---EDLKQAMRTLSDLDTVALDAKKESAFLRSENLELKEKINELSDSRKQMESDIQMYQRQLE 680

  Fly   654 ----------------------------GEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDS 690
                                        |:..|...:.|.|:..||:.:.:...:|:||:|:::.
Mouse   681 AKKKMQTDLDKELQLAFQEISKLSALVDGKGLLSNLELEKRITDLQKELNKEAEEKQTLQEEVNL 745

  Fly   691 LREECAKLKA-AEHVSAVNAEEKQRAEEL-------RSMF------DSQMDELREAHTRQVSELR 741
            |.|    ||: ...|..:..|..:::|||       ..:|      ||::..|.|    ::...|
Mouse   746 LSE----LKSLPSEVETLRRELYEKSEELHIITTEREKLFSEMAHKDSRIQGLLE----EIGNTR 802

  Fly   742 DEIAAKQ-------HEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKSSELQNIILTNERREQA 799
            |::|..|       .|...::.:|.:|...|..:..:.|:::||....|.|.:::..:
Mouse   803 DDLATSQLSRRGSDGEWQALESLHAELEHRHAGVLEERERLKQEIGALSKEAESLAFS------- 860

  Fly   800 RKDLKGLEDTVAKELQTLHNLRKLFVQDL--QQRIRK-NVVNEESEEDGGSL--AQKQKISFLEN 859
                   .|:|..||.  |..::|..:.:  |:|:.| ..:.||.|....||  .:|:|: .|..
Mouse   861 -------LDSVKAELS--HKTQELEQKTVEGQERLNKMEALREELESRDSSLQSVEKEKV-LLTE 915

  Fly   860 NLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKA-------LETALKEAKEGAMRDRKRY 917
            .|.|..|..|.|.::..:|:    :|::.|:...:::::       :....:|....|:...|::
Mouse   916 KLQQALKEVKALTQEKKNLK----QLQESLQTERDQLRSDIQDTVNMNIDTQEQLLNALESLKQH 976

  Fly   918 QYEVDRIKEAVRQK-----HLGRRGPQAQIAKPIRSG-----QGAIAIRGGG 959
            |..::.:|....::     |:..||.....|:....|     :.|..:.|||
Mouse   977 QETINMLKMKAAEELSDNLHVKDRGGARDEAQQKMDGIDEQNESAHTLLGGG 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	150/333 (45%)
		KISc	12..340	CDD:214526	151/338 (45%)
		Apolipoprotein	595..744	CDD:279749	44/205 (21%)
Cenpe	NP_776123.3	KISc	6..336	CDD:214526	151/338 (45%)
		KISc_CENP_E	6..329	CDD:276825	149/331 (45%)
		SMC_prok_B	586..1436	CDD:274008	100/483 (21%)
		DUF972	1041..>1119	CDD:283750
		SCP-1	1100..1841	CDD:114219
		SbcC	1570..2128	CDD:223496
		Kinetochore binding domain. /evidence=ECO:0000250|UniProtKB:Q02224	1959..2249
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2193..2214
		Globular autoinhibitory domain. /evidence=ECO:0000250	2283..2468
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2368..2438

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910