DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and klp-11

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001369897.1	Gene:	klp-11 / 177685	WormBaseID:	WBGene00002222	Length:	782	Species:	Caenorhabditis elegans

Alignment Length:	851	Identity:	246/851 - (28%)
Similarity:	393/851 - (46%)	Gaps:	150/851 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDSIKVVCRFRPLNDSEEKAG--SKFV----------VKFPNNVEENCISIAGKVYLFDKVFKPN 62
            ::::||:.|.|||: |:|.|.  ||.|          :|.|...:|     ..|.:.||.::..|
Worm    11 QETVKVIVRCRPLS-SQEIANNYSKIVHMRPQRGQIELKNPKEQDE-----PSKDFTFDAIYDEN 69

  Fly    63 ASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIY 127
            ::|..:|.|..:.:|..||.|||.||||||||.:||||||||...|..::|:|.:.::.||.|:.
Worm    70 STQSDLYEETFRDLVDSVLNGYNATIFAYGQTGTGKTHTMEGKSSDPEQRGVIYKCIDHIFEHMA 134

  Fly   128 AMEVNLEFHIKVSYYEIYMDKIRDLLDV-SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIE 191
            |.. |.|:.::.||.|||.:::||||:. |...|.:.|..:...|||..|.:...:..::.||:.
Worm   135 ASH-NQEYLVRASYLEIYQEELRDLLEAESNKKLEIKERPDGGVYVKDLTSKLTRTVGEIHEVMI 198

  Fly   192 EGKSNRHIAVTNMNEHSSRSHSVFLINVKQENL--ENQKKLS-GKLYLVDLAGSEKVSKTGAEGT 253
            .|..:|.:..|||||||||||::|:|.|:...:  :.:..:: |:|.||||||||:.|||||.|.
Worm   199 RGNGHRSVGRTNMNEHSSRSHAIFIITVECSRIGEDGESHITVGRLNLVDLAGSERQSKTGATGE 263

  Fly   254 VLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNES 318
            ...||..||.||||||||||||.|....|||||||||||:||:|||||::|.:|.|..|||:|..
Worm   264 RFKEATKINLSLSALGNVISALVDAKSAHIPYRDSKLTRLLQDSLGGNSKTVMVACIGPASYNFE 328

  Fly   319 ETKSTLDFGRRAKTVKNVVCVNE--------------ELTAEEWKRRYEKEKE---------KNA 360
            ||..||.:..|||.:||...:||              |:..|:.|:|..:.::         :.|
Worm   329 ETLGTLRYANRAKNIKNQPKINEDPKDALLREFQEEIEMLREQLKQRKTRSRDGATQSFYDAERA 393

  Fly   361 RLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAALAAQRTALANM 425
            :|:..:|.::      :....:|.|:...:.::.|      :.:..:....|.|..|:|.|....
Worm   394 KLEDDIEAIQ------KDDSLIKHEKDRLIREIQE------KHDLLEKERIEQARVAERIANIQS 446

  Fly   426 SASVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEM 490
            ...|...|..||.:..:..:.||:.|..|:.:|.:...::.|.:..|||...:.::.:..|::|:
Worm   447 RLIVGSEEDGRLESRTKEQHAQLEKKRRELAEQKRREREMVEALERQEEDTVDLKQTFSDLRTEV 511

  Fly   491 ARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQ 555
                   |:..:::|::|..|.:........|....::.:|:|                    |.
Worm   512 -------EAKTKKLKKMLIKLRQARNEIRDVSGAYSDERQDLD--------------------QT 549

  Fly   556 LKDMSSHQKKRITEMLTNLLRDLGE-VGQAIAPGESSIDLKMSALAGTDAS---------KVEED 610
            :.::|...|.::..:...:.||:.| :.:.....|.|.:..::|...|.::         :|.||
Worm   550 IAEVSKELKLKLLIVENFIPRDVSERIKERAEWNEDSFEWNVNAFQSTSSNSSTPLNNTIEVNED 614

  Fly   611 FTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKIS-----EYEKDLGEYRLLISQHEARMKSL 670
            ....|                     :..|||...:|     .......:.||:.:....|..|:
Worm   615 GVFTR---------------------SSGADSGVSVSGGNGTPATSQFLDKRLVATPGCRRPMSM 658

  Fly   671 QESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFDSQMDELREAHTR 735
            .|.|     ...|..||..:.|..... .:...|.|...||..|       |..:...:..|..|
Worm   659 CERM-----LVETAREQFGAQRRPPIS-GSGSFVEATIPEETIR-------FCGENVVVFSALER 710

  Fly   736 QVSELRDEIAAKQHEMDEMKDVHQKLLLAH----QQMTADYEKVRQEDAEKSSELQNIILTNERR 796
            .|.|:.|.        |.....:..::.|.    :.:|.|..||......:|:    :||.|.:.
Worm   711 FVPEVTDS--------DPSTFSNSMMMSARRPSIENLTIDASKVLVPILNQST----MILKNSKN 763

  Fly   797 EQARKD 802
            .|||.|
Worm   764 GQARND 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	152/338 (45%)
		KISc	12..340	CDD:214526	154/343 (45%)
		Apolipoprotein	595..744	CDD:279749	31/162 (19%)
klp-11	NP_001369897.1	Motor_domain	12..343	CDD:419868	152/337 (45%)
klp-11	NP_001369897.1	SMC_prok_B	337..>584	CDD:274008	50/285 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910