Protein Alignment Khc and klp-18

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_501093.1
• Gene: klp-18 / 177474
• WormBaseID: WBGene00002228
• Length: 932
• Species: Caenorhabditis elegans
• Alignment Length: 1045
• Identity: 268/1045 - (25%)
• Similarity: 442/1045 - (42%)
• Gaps: 229/1045 - (21%)

  Fly    13 IKVVCRFRP---LNDSEEK--AGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            ||...|.||   |....|.  .|.:.|....:|        ..|.|....:|..::|||.|:...
 Worm     5 IKCYGRVRPSARLGAPSESLFVGGRVVTIETDN--------GSKRYELHHIFDSSSSQEDVFGTV 61

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIG---DSVKQGIIPRIVNDIFNHI--YAMEV- 131
            ||.||.|.:.|||||:||||||.|||||||.|...   |....|:|||.|..:|.|:  .|.|.
 Worm    62 AKKIVEDCVEGYNGTVFAYGQTGSGKTHTMLGPCDSWTDQELMGLIPRSVEHVFQHLDTKAKECQ 126

  Fly   132 NLEFHIKVSYYEIYMDKIRDLLDV-SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKS 195
            .|.|.:.|.:.|:|.:.|.|||:. :||.|   .|..:...:.||..:.|.:|.|:..::::|..
 Worm   127 KLTFSVSVEFVELYNEVIYDLLNAKNKVQL---RDSGKDIQLVGALSKNVDNPLDLMHLVQKGWQ 188

  Fly   196 NRHIAVTNMNEHSSRSHSVFLINVKQENLENQ--KKLSGKLYLVDLAGSEKVSKTGAEGTVLDEA 258
            .|....|.||..|||||::.:|.:|.:....:  |:.|..|.||||||||:.:.|.:.|..|.||
 Worm   189 ERSTGSTAMNAESSRSHALLIIRIKTQERTGELVKERSSILNLVDLAGSERQTHTKSSGDRLKEA 253

  Fly   259 KNINKSLSALGNVISALADGNKT--HIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETK 321
            .|||.||:.||..|..|||.:|.  |:|||||.||.||:.|||||::|.:::...|......|:.
 Worm   254 TNINSSLTVLGRCIRLLADPSKAKGHVPYRDSHLTHILKNSLGGNSKTAVIVNMHPDRDFAQESN 318

  Fly   322 STLDFGRRAKTVKNVVCVNEELTA----------EEWKRRYEKEKEK-NARLKGKVEKLEIELAR 375
            |||.|.:....:.|:...||.:|.          :|.::..::.:|| ......::::.|:|..|
 Worm   319 STLMFAQSCTMIMNIATRNEVMTGDQESSYKKAIQELRQEVDETREKVRTEFASQLDEAEVEQLR 383

  Fly   376 WRAGETVKAEEQINMEDLMEAS----TPNLEVE---------AAQTAAAEAALAAQRTALANMSA 427
            .:........|.:::....:.:    |...|.|         .::.:||.::...:..||.|.:.
 Worm   384 LKTENNSLRLENVDLRAKYDFALLKYTIGSENEQIVNEFKKIISEFSAANSSSPFECIALKNQTL 448

  Fly   428 SVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMAR 492
            .:.:...       |:.||:|..:...:  :::|.|.|...::               :|:..|:
 Worm   449 QLEIEAS-------EKRYQELQKETSAL--RNRYQENLDATIL---------------MQTPSAK 489

  Fly   493 IQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLK 557
            .::.:...|....:...:...:|:..:.::.|  :...|:...||:|          |.||..||
 Worm   490 ERRSSSRPKRRETQYRPSPARMALFAEVETSE--DAVLDLQCQNEKL----------SCELSSLK 542

  Fly   558 DMSSHQK---KRI-TEMLTN-----LLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTM 613
            |  .|::   |.| ||.|..     |.:::..|.:::...|:.            |...:|..|.
 Worm   543 D--KHEEATSKSIETERLLQGEIVALQKEVSIVSESLRKSEAV------------AEGYKEKVTA 593

  Fly   614 ARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRL----LISQHEARMKSLQESM 674
            ..|.:.|:........:|.:.:|....:|..:.||   :|.|.||    :|...|.:......::
 Worm   594 NNLTLDKLLLHIDASRKRIAELELSSKESENRSSE---ELEEQRLYYVSMIEDLERKASDEYAAL 655

  Fly   675 REAENKK----RTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFD-----SQM---- 726
            ||..|:|    ..|:.|:|.|:...|.:|      .:||:...:|..:||:.|     |||
 Worm   656 REELNQKTLSSNLLQVQVDELQLSNATIK------KLNADLSTKAGLIRSLEDSIEKKSQMITRL 714

  Fly   727 --------------------DELREAHTRQVSELRDEIAAKQHEM-DEMKDVHQ-----KLLLAH 765
                                ..|.....|::||  :..:|.|.:: |..||:.|     ||.:..
 Worm   715 EEQAVLDSSELSSTKRQLEHSRLEAIQWRKISE--ETTSAMQTQLKDHQKDIDQCRHKKKLEIQS 777

  Fly   766 QQMTADYEKVRQEDAE----------------KSSELQNIILTNERREQARKDLKGLEDTVAKEL 814
            .|::.|....|.:::|                |.||::|..     :|:....||..|||:.::
 Worm   778 MQLSLDNANARVKESEAMMKKLQNDEKQKFDMKMSEIENTF-----KEKLSVSLKKQEDTIRRQ- 836

  Fly   815 QTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRD----N 875
            ....|..||.|.:.:.|:                        |...::.|...|.|   |    |
 Worm   837 SLAENQGKLEVMENKNRV------------------------LSETIESLQSQHSQ---DTEVIN 874

  Fly   876 ADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQA 940
            |.||....::....:..:|: ||||..:.:.:.           |.|::|:.:|.:...:...::
 Worm   875 AGLRTRGDRVGYVDKLRVEK-KALEETISQLRS-----------ENDKLKKIMRGESANKPVLRS 927

  Fly   941 QIAKP 945
            |..||
 Worm   928 QTTKP 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	131/335 (39%)
		Smc	<341..>807	CDD:440809	106/557 (19%)
		Khc_CBD_cc	856..925	CDD:467880	16/72 (22%)
klp-18	NP_501093.1	KISc	5..328	CDD:276812	131/333 (39%)
		SMC_prok_B	<448..>716	CDD:274008	66/326 (20%)
		SMC_N	543..>917	CDD:481474	93/443 (21%)