DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and klp-18

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_501093.1	Gene:	klp-18 / 177474	WormBaseID:	WBGene00002228	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	1045	Identity:	268/1045 - (25%)
Similarity:	442/1045 - (42%)	Gaps:	229/1045 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IKVVCRFRP---LNDSEEK--AGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            ||...|.||   |....|.  .|.:.|....:|        ..|.|....:|..::|||.|:...
Worm     5 IKCYGRVRPSARLGAPSESLFVGGRVVTIETDN--------GSKRYELHHIFDSSSSQEDVFGTV 61

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIG---DSVKQGIIPRIVNDIFNHI--YAMEV- 131
            ||.||.|.:.|||||:||||||.|||||||.|...   |....|:|||.|..:|.|:  .|.|.
Worm    62 AKKIVEDCVEGYNGTVFAYGQTGSGKTHTMLGPCDSWTDQELMGLIPRSVEHVFQHLDTKAKECQ 126

  Fly   132 NLEFHIKVSYYEIYMDKIRDLLDV-SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKS 195
            .|.|.:.|.:.|:|.:.|.|||:. :||.|   .|..:...:.||..:.|.:|.|:..::::|..
Worm   127 KLTFSVSVEFVELYNEVIYDLLNAKNKVQL---RDSGKDIQLVGALSKNVDNPLDLMHLVQKGWQ 188

  Fly   196 NRHIAVTNMNEHSSRSHSVFLINVKQENLENQ--KKLSGKLYLVDLAGSEKVSKTGAEGTVLDEA 258
            .|....|.||..|||||::.:|.:|.:....:  |:.|..|.||||||||:.:.|.:.|..|.||
Worm   189 ERSTGSTAMNAESSRSHALLIIRIKTQERTGELVKERSSILNLVDLAGSERQTHTKSSGDRLKEA 253

  Fly   259 KNINKSLSALGNVISALADGNKT--HIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETK 321
            .|||.||:.||..|..|||.:|.  |:|||||.||.||:.|||||::|.:::...|......|:.
Worm   254 TNINSSLTVLGRCIRLLADPSKAKGHVPYRDSHLTHILKNSLGGNSKTAVIVNMHPDRDFAQESN 318

  Fly   322 STLDFGRRAKTVKNVVCVNEELTA----------EEWKRRYEKEKEK-NARLKGKVEKLEIELAR 375
            |||.|.:....:.|:...||.:|.          :|.::..::.:|| ......::::.|:|..|
Worm   319 STLMFAQSCTMIMNIATRNEVMTGDQESSYKKAIQELRQEVDETREKVRTEFASQLDEAEVEQLR 383

  Fly   376 WRAGETVKAEEQINMEDLMEAS----TPNLEVE---------AAQTAAAEAALAAQRTALANMSA 427
            .:........|.:::....:.:    |...|.|         .::.:||.::...:..||.|.:.
Worm   384 LKTENNSLRLENVDLRAKYDFALLKYTIGSENEQIVNEFKKIISEFSAANSSSPFECIALKNQTL 448

  Fly   428 SVAVNEQARLATECERLYQQLDDKDEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMAR 492
            .:.:...       |:.||:|..:...:  :::|.|.|...::               :|:..|:
Worm   449 QLEIEAS-------EKRYQELQKETSAL--RNRYQENLDATIL---------------MQTPSAK 489

  Fly   493 IQQENESAKEEVKEVLQALEELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLK 557
            .::.:...|....:...:...:|:..:.::.|  :...|:...||:|          |.||..||
Worm   490 ERRSSSRPKRRETQYRPSPARMALFAEVETSE--DAVLDLQCQNEKL----------SCELSSLK 542

  Fly   558 DMSSHQK---KRI-TEMLTN-----LLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTM 613
            |  .|::   |.| ||.|..     |.:::..|.:::...|:.            |...:|..|.
Worm   543 D--KHEEATSKSIETERLLQGEIVALQKEVSIVSESLRKSEAV------------AEGYKEKVTA 593

  Fly   614 ARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRL----LISQHEARMKSLQESM 674
            ..|.:.|:........:|.:.:|....:|..:.||   :|.|.||    :|...|.:......::
Worm   594 NNLTLDKLLLHIDASRKRIAELELSSKESENRSSE---ELEEQRLYYVSMIEDLERKASDEYAAL 655

  Fly   675 REAENKK----RTLEEQIDSLREECAKLKAAEHVSAVNAEEKQRAEELRSMFD-----SQM---- 726
            ||..|:|    ..|:.|:|.|:...|.:|      .:||:...:|..:||:.|     |||
Worm   656 REELNQKTLSSNLLQVQVDELQLSNATIK------KLNADLSTKAGLIRSLEDSIEKKSQMITRL 714

  Fly   727 --------------------DELREAHTRQVSELRDEIAAKQHEM-DEMKDVHQ-----KLLLAH 765
                                ..|.....|::||  :..:|.|.:: |..||:.|     ||.:..
Worm   715 EEQAVLDSSELSSTKRQLEHSRLEAIQWRKISE--ETTSAMQTQLKDHQKDIDQCRHKKKLEIQS 777

  Fly   766 QQMTADYEKVRQEDAE----------------KSSELQNIILTNERREQARKDLKGLEDTVAKEL 814
            .|::.|....|.:::|                |.||::|..     :|:....||..|||:.::
Worm   778 MQLSLDNANARVKESEAMMKKLQNDEKQKFDMKMSEIENTF-----KEKLSVSLKKQEDTIRRQ- 836

  Fly   815 QTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRD----N 875
            ....|..||.|.:.:.|:                        |...::.|...|.|   |    |
Worm   837 SLAENQGKLEVMENKNRV------------------------LSETIESLQSQHSQ---DTEVIN 874

  Fly   876 ADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQA 940
            |.||....::....:..:|: ||||..:.:.:.           |.|::|:.:|.:...:...::
Worm   875 AGLRTRGDRVGYVDKLRVEK-KALEETISQLRS-----------ENDKLKKIMRGESANKPVLRS 927

  Fly   941 QIAKP 945
            |..||
Worm   928 QTTKP 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	131/335 (39%)
		KISc	12..340	CDD:214526	132/342 (39%)
		Apolipoprotein	595..744	CDD:279749	39/185 (21%)
klp-18	NP_501093.1	KISc	5..328	CDD:276812	131/333 (39%)
klp-18	NP_501093.1	SbcC	342..913	CDD:223496	128/676 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910