DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and osm-3

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001367796.1	Gene:	osm-3 / 177141	WormBaseID:	WBGene00003884	Length:	699	Species:	Caenorhabditis elegans

Alignment Length:	770	Identity:	236/770 - (30%)
Similarity:	357/770 - (46%)	Gaps:	185/770 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEE---NCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            :|::|..|.||.|..|:...:...|....||.:   |....|.|.:.||..:..:::.|::||:.
Worm     3 ESVRVAVRCRPFNQREKDLNTTLCVGMTPNVGQVNLNAPDGAAKDFTFDGAYFMDSTGEQIYNDI 67

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIY---AMEVNLE 134
            ...:|.:|:.|||||:||||||.||||.:|:|:.....::|:|||    .|:||:   |...|::
Worm    68 VFPLVENVIEGYNGTVFAYGQTGSGKTFSMQGIETIPAQRGVIPR----AFDHIFTATATTENVK 128

  Fly   135 FHIKVSYYEIYMDKIRDLLDV-SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRH 198
            |.:..||.|||.:::||||.. :|..|.:.|..:|..||.|.:...........|::..|.:|||
Worm   129 FLVHCSYLEIYNEEVRDLLGADNKQKLEIKEQPDRGVYVAGLSMHVCHDVPACKELMTRGFNNRH 193

  Fly   199 IAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINK 263
            :..|.||:.||||||:|.:.| :...|......|||.||||||||:.|||||.|..|.||..||.
Worm   194 VGATLMNKDSSRSHSIFTVYV-EGMTETGSIRMGKLNLVDLAGSERQSKTGATGDRLKEATKINL 257

  Fly   264 SLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGR 328
            ||||||||||||.||...|||||||||||:||:|||||.:|.::.|.||:|.|..||.|||.:..
Worm   258 SLSALGNVISALVDGKSKHIPYRDSKLTRLLQDSLGGNTKTIMIACVSPSSDNYDETLSTLRYAN 322

  Fly   329 RAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDL 393
            |||.:||...:||: ..:...|.|:   |:.||||..|:...:       |....|::..::|:
Worm   323 RAKNIKNKPTINED-PKDALLREYQ---EEIARLKSMVQPGAV-------GVGAPAQDAFSIEE- 375

  Fly   394 MEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQ 458
                                                            ||
Worm   376 ------------------------------------------------ER--------------- 377

  Fly   459 SQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQ 523
                ::|:|   |.||.:.:.|.|||..|:..|.:|::              ||.|..:|::.:.
Worm   378 ----KKLRE---EFEEAMNDLRGEYEREQTSKAELQKD--------------LESLRADYERANA 421

  Fly   524 EIDNKNKDIDALNEELQQKQSVF----NAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQA 584
            .:||.|.:..|  :::||.|..|    .|.:|:|:|         ||:.::
Worm   422 NLDNLNPEEAA--KKIQQLQDQFIGGEEAGNTQLKQ---------KRMKQL-------------- 461

  Fly   585 IAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEY 649
                 ...:.|...||.  |..|.:|..:.:::    .|..:.:....|.:|.:.    ||...|
Worm   462 -----KEAETKTQKLAA--ALNVHKDDPLLQVY----STTQEKLDAVTSQLEKEV----KKSKGY 511

  Fly   650 EKDL----GEYRL-------LISQHEARMKSLQESMREAEN--KKRTLEEQIDSLREECA----- 696
            |:::    ||:.|       .|.:.:.::|.|.:.|.:.:.  ||.|....:|.:::|..
Worm   512 EREIEDLHGEFELDRLDYLDTIRKQDQQLKLLMQIMDKIQPIIKKDTNYSNVDRIKKEAVWNEDE 576

  Fly   697 ------KLKAAEHV--SAVNA--EEKQRAEE--LRSMFDSQMDELREAHTRQVSE 739
                  ::..:..:  .|.|.  :|..|.|.  |||.||   |:|||...:..||
Worm   577 SRWILPEMSMSRTILPLANNGYMQEPARQENTLLRSNFD---DKLRERLAKSDSE 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	148/328 (45%)
		KISc	12..340	CDD:214526	150/334 (45%)
		Apolipoprotein	595..744	CDD:279749	41/175 (23%)
osm-3	NP_001367796.1	Motor_domain	3..327	CDD:419868	148/328 (45%)
osm-3	NP_001367796.1	SMC_prok_B	<342..559	CDD:274008	65/351 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910