Protein Alignment Khc and osm-3

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001367796.1
• Gene: osm-3 / 177141
• WormBaseID: WBGene00003884
• Length: 699
• Species: Caenorhabditis elegans
• Alignment Length: 770
• Identity: 236/770 - (30%)
• Similarity: 357/770 - (46%)
• Gaps: 185/770 - (24%)

  Fly    11 DSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEE---NCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            :|::|..|.||.|..|:...:...|....||.:   |....|.|.:.||..:..:::.|::||:.
 Worm     3 ESVRVAVRCRPFNQREKDLNTTLCVGMTPNVGQVNLNAPDGAAKDFTFDGAYFMDSTGEQIYNDI 67

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIY---AMEVNLE 134
            ...:|.:|:.|||||:||||||.||||.:|:|:.....::|:|||    .|:||:   |...|::
 Worm    68 VFPLVENVIEGYNGTVFAYGQTGSGKTFSMQGIETIPAQRGVIPR----AFDHIFTATATTENVK 128

  Fly   135 FHIKVSYYEIYMDKIRDLLDV-SKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRH 198
            |.:..||.|||.:::||||.. :|..|.:.|..:|..||.|.:...........|::..|.:|||
 Worm   129 FLVHCSYLEIYNEEVRDLLGADNKQKLEIKEQPDRGVYVAGLSMHVCHDVPACKELMTRGFNNRH 193

  Fly   199 IAVTNMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINK 263
            :..|.||:.||||||:|.:.| :...|......|||.||||||||:.|||||.|..|.||..||.
 Worm   194 VGATLMNKDSSRSHSIFTVYV-EGMTETGSIRMGKLNLVDLAGSERQSKTGATGDRLKEATKINL 257

  Fly   264 SLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGR 328
            ||||||||||||.||...|||||||||||:||:|||||.:|.::.|.||:|.|..||.|||.:..
 Worm   258 SLSALGNVISALVDGKSKHIPYRDSKLTRLLQDSLGGNTKTIMIACVSPSSDNYDETLSTLRYAN 322

  Fly   329 RAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDL 393
            |||.:||...:||: ..:...|.|:   |:.||||..|:...:       |....|::..::|:
 Worm   323 RAKNIKNKPTINED-PKDALLREYQ---EEIARLKSMVQPGAV-------GVGAPAQDAFSIEE- 375

  Fly   394 MEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQ 458
                                                            ||
 Worm   376 ------------------------------------------------ER--------------- 377

  Fly   459 SQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQ 523
                ::|:|   |.||.:.:.|.|||..|:..|.:|::              ||.|..:|::.:.
 Worm   378 ----KKLRE---EFEEAMNDLRGEYEREQTSKAELQKD--------------LESLRADYERANA 421

  Fly   524 EIDNKNKDIDALNEELQQKQSVF----NAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQA 584
            .:||.|.:..|  :::||.|..|    .|.:|:|:|         ||:.::
 Worm   422 NLDNLNPEEAA--KKIQQLQDQFIGGEEAGNTQLKQ---------KRMKQL-------------- 461

  Fly   585 IAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEY 649
                 ...:.|...||.  |..|.:|..:.:::    .|..:.:....|.:|.:.    ||...|
 Worm   462 -----KEAETKTQKLAA--ALNVHKDDPLLQVY----STTQEKLDAVTSQLEKEV----KKSKGY 511

  Fly   650 EKDL----GEYRL-------LISQHEARMKSLQESMREAEN--KKRTLEEQIDSLREECA----- 696
            |:::    ||:.|       .|.:.:.::|.|.:.|.:.:.  ||.|....:|.:::|..
 Worm   512 EREIEDLHGEFELDRLDYLDTIRKQDQQLKLLMQIMDKIQPIIKKDTNYSNVDRIKKEAVWNEDE 576

  Fly   697 ------KLKAAEHV--SAVNA--EEKQRAEE--LRSMFDSQMDELREAHTRQVSE 739
                  ::..:..:  .|.|.  :|..|.|.  |||.||   |:|||...:..||
 Worm   577 SRWILPEMSMSRTILPLANNGYMQEPARQENTLLRSNFD---DKLRERLAKSDSE 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	148/328 (45%)
		Smc	<341..>807	CDD:440809	85/433 (20%)
		Khc_CBD_cc	856..925	CDD:467880
osm-3	NP_001367796.1	Motor_domain	3..327	CDD:473979	148/328 (45%)
		SMC_prok_B	<342..559	CDD:274008	65/351 (19%)
		OmpH	384..>470	CDD:461098	28/129 (22%)