DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and Kif7

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001278151.1	Gene:	Kif7 / 16576	MGIID:	1098239	Length:	1348	Species:	Mus musculus

Alignment Length:	1108	Identity:	299/1108 - (26%)
Similarity:	471/1108 - (42%)	Gaps:	256/1108 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAEREIPAEDS-IKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISI---AGKVYL------- 54
            :.|:|...||:: ::|..|.|||...|...|           .::|:.:   .|::.|
Mouse     3 LEAQRLPGAEEAPVRVALRVRPLLPKELLHG-----------HQSCLRVEPERGRITLGRDRHFG 56

  Fly    55 FDKVFKPNASQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSV---KQGIIP 116
            |..|...:..||.||....:.::.....|:|.|:||||||.||||:||......|:   :|||||
Mouse    57 FHVVLGEDTGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTMGEASVASLHEDEQGIIP 121

  Fly   117 RIVNDIFNHIYAMEVNLEFHIKVSYYEIYMDKIRDLLDVSKV--NLSVHEDKNRVPYVKGATERF 179
            |.:.:.|..|...:: |:..:.|||.|:|.::.||||:|...  ::.:.||......:.|..|..
Mouse   122 RAMAEAFKLIDENDL-LDCLVHVSYLELYKEEFRDLLEVGTASRDIQLREDDRGNVVLCGVKEVD 185

  Fly   180 VSSPEDVFEVIEEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENLENQK--------KLSGKLYL 236
            |...::|..::|.|.:.||...|:.|..|||||:||.:.::|......:        .|..|.:.
Mouse   186 VEGLDEVLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRTPSRLPRPAAGHLLVSKFHF 250

  Fly   237 VDLAGSEKVSKTGAEGTVLDEAKNINKSLSALGNVISALADGNK--THIPYRDSKLTRILQESLG 299
            |||||||:|.|||:.|..|.|:..||.:|.|||||||||.|..:  :||||||||:||||::|||
Mouse   251 VDLAGSERVLKTGSTGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRILKDSLG 315

  Fly   300 GNARTTIVICCSPASFNESETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNA---- 360
            |||:|.::.|.||:|.:..||.:||::..||:.::|...||       |:...|:..|:.|
Mouse   316 GNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVN-------WRPEAERVPEEQAAGAR 373

  Fly   361 ---------RL--KGK------------VEKLEIELARWRAGETVKAEEQINMEDLMEASTPNLE 402
                     |:  :|:            ...|..|.||.||  ...|...:..|...|...|.
Mouse   374 GPPRHRSETRIIHRGRRVPCPAVGSAAVAAGLGAECARCRA--RTSAAYSLLRELQAEPGLPG-- 434

  Fly   403 VEAAQTAAAE------AALAAQRTALANMSA------SVAVNEQARLATECERLYQQLDDKDEEI 455
                  |||.      .|:..:|:.|::.|.      |....:||...|.        ..|.:|.
Mouse   435 ------AAARKVRDWLCAVEGERSTLSSASGPDSGIESAPAEDQAAQGTS--------GRKGDEG 485

  Fly   456 NQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQ 520
            .||                |:        ||||::||:::||       ::.|.|||:....|..
Mouse   486 TQQ----------------LL--------TLQSQVARLEEEN-------RDFLAALEDAMEQYKL 519

  Fly   521 KSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAI 585
            :|..:..:.:::..|...|:..|..:.|... ||.|...|...:.....:.......||.:....
Mouse   520 QSDRLREQQEEMVELRLRLELAQPGWGAPGL-LQGLPPGSFVPRPHTAPLGGAHTHMLGMMPSTC 583

  Fly   586 APGE---------SSIDLKMSALAGTD----ASKV-------------EEDFTMARLFISKMKTE 624
            .|||         |..::|...||..|    ||..             ||:....|..:...:..
Mouse   584 LPGEEVSSEQQVVSGKEVKAEVLAQADKLRSASSTTSEEEGEEEEEEEEEEEEPPRRTLYLRRNG 648

  Fly   625 AKNIAQRCSNMETQQAD-SNKKISEYE--------KDLGEYRLLISQHEA--------RMKSLQE 672
            ..|.:||.........| ...::...|        :.:|..::.:...:|        |:...|:
Mouse   649 ISNWSQRAGLSPGSPPDRKGPEVCPEEPAAAIPAPQAVGSGKVPVQTRQAPAAMASEWRLAQAQQ 713

  Fly   673 SMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQR-------AEELRSMFDSQMDELR 730
            .:||.....|..||.|..|      ::..:...|:|.:..||       ||.:|:.......:||
Mouse   714 KIRELAINIRMKEELIGEL------VRTGKAAQALNRQHSQRIRELEQEAERVRAELCEGQRQLR 772

  Fly   731 EAHTRQ---------VSELRDEIAAKQHE---MDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKS 783
            |...|:         :.|.|..:||.|.:   :.|.|...::|:....|     .:.|.::.|::
Mouse   773 ELEGREPQDASERSRLQEFRKRVAAAQSQVQVLKEKKQATERLVSLSAQ-----SETRLQELERN 832

  Fly   784 SELQNIILTNERREQARKDLKGLEDTVAK-ELQTLHNLRKLFVQDL------QQRIRKNVVNEE- 840
            .:|.       ||:|.:...:..|:|..| .|:|..|.|:..|::|      ||:|.| :..||
Mouse   833 VQLM-------RRQQGQLQRRLREETEQKRRLETEMNKRQHRVKELELKHEQQQKILK-IKTEEI 889

  Fly   841 --------SEEDGG--SLAQKQKISFLENNLDQ-LTKVHKQLVRDNADLRCELPKLEKRLRCTME 894
                    |..:|.  ||.|:|||...:..||| :.||.:|        |..|.:|.:.|| ..|
Mouse   890 AAFQRKRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQ--------RRALEELGEELR-KRE 945

  Fly   895 RVKALETALKEAKEG--AMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQGAIAIRG 957
            .:.|.:.||.:.|.|  :.|.|.......|.::.:.|.:||     :.::::  :|||    :|.
Mouse   946 VILAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHL-----EKELSE--KSGQ----LRQ 999

  Fly   958 GGA 960
            |.|
Mouse  1000 GSA 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	130/348 (37%)
		KISc	12..340	CDD:214526	130/353 (37%)
		Apolipoprotein	595..744	CDD:279749	38/198 (19%)
Kif7	NP_001278151.1	KISc_KIF4	15..350	CDD:276823	129/346 (37%)
		Interaction with SMO. /evidence=ECO:0000269\|PubMed:25644602	358..1211		162/734 (22%)
		Interaction with DLG5. /evidence=ECO:0000269\|PubMed:25644602	358..479		26/138 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..486		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..674		11/66 (17%)
		Smc	<734..1063	CDD:224117	78/302 (26%)
		PRK11281	949..>1202	CDD:236892	17/65 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1314
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1328..1348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910