DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Khc and Kif5c

DIOPT Version :9

Sequence 1:NP_476590.1 Gene:Khc / 36810 FlyBaseID:FBgn0001308 Length:975 Species:Drosophila melanogaster
Sequence 2:NP_032475.2 Gene:Kif5c / 16574 MGIID:1098269 Length:956 Species:Mus musculus


Alignment Length:984 Identity:601/984 - (61%)
Similarity:750/984 - (76%) Gaps:64/984 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            |||.||||:|||||||::|...|.||:.||..  ||..:...||.|:||:|..||.:||:|||..
Mouse     4 PAECSIKVMCRFRPLNEAEILRGDKFIPKFKG--EETVVIGQGKPYVFDRVLPPNTTQEQVYNAC 66

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHI 137
            ||.||.|||.||||||||||||||||||||||.:.|....||||||.:|||:|||:|:.||||||
Mouse    67 AKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHI 131

  Fly   138 KVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVT 202
            ||||:|||:|||||||||||.||:|||||||||||||.|||||||||:|.:||:|||:|||:|||
Mouse   132 KVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVT 196

  Fly   203 NMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSA 267
            |||||||||||:||||:||||:|.:|||||||||||||||||||||||||.||||||||||||||
Mouse   197 NMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSA 261

  Fly   268 LGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKT 332
            |||||||||:|.|||:||||||:|||||:|||||.||||||||||:.|||:||||||.||:||||
Mouse   262 LGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKT 326

  Fly   333 VKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMED----- 392
            :||.|.||.||||||||::||||||||..||..::.||:||.|||.||.|..:|||:.:|     
Mouse   327 IKNTVSVNLELTAEEWKKKYEKEKEKNKALKSVLQHLEMELNRWRNGEAVPEDEQISAKDQKSLE 391

  Fly   393 ------LMEASTPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDK 451
                  :::..||.::                     .:||     |:.:...|...||:|||||
Mouse   392 PCDNTPIIDNITPVVD---------------------GISA-----EKEKYDEEITSLYRQLDDK 430

  Fly   452 DEEINQQSQYAEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAV 516
            |:|||||||.||:||:|:::|:||:|:.||:||.:|.|:.|:|.|||:||:||||||||||||||
Mouse   431 DDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAV 495

  Fly   517 NYDQKSQEIDNKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEV 581
            ||||||||:::|.:..:.|.:||.||.:.......||.||:::|:|||||.||:|..||:||||:
Mouse   496 NYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKDLGEI 560

  Fly   582 GQAIAPGESSIDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKI 646
            |..|...:      :..||..: ..:||:||||||:|||||:|.|::..|...:|:.|.|||:|:
Mouse   561 GGIIGTND------VKTLADVN-GVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNRKM 618

  Fly   647 SEYEKDLGEYRLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEE 711
            :..|::|...:||||||||::|||.:.|:..|.|:|.|||..|||.||.|||:|.|.:..|:.::
Mouse   619 NASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVSFQD 683

  Fly   712 KQR--------AEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQM 768
            |::        |||::...:.||:..||||.:|:|.|||||..||..:||::|::|||.|..:::
Mouse   684 KEKEHLTRLQDAEEVKKALEQQMESHREAHQKQLSRLRDEIEEKQRIIDEIRDLNQKLQLEQERL 748

  Fly   769 TADYEKVRQEDAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIR 833
            ::||.|::.||.|:..:|:.::|.|::|||||:||||||:||::||||||||||||||||..|::
Mouse   749 SSDYNKLKIEDQEREVKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVK 813

  Fly   834 KNVVNEESEEDGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKA 898
            |: |..:|::.|||.|||||||||||||:||||||||||||||||||||||||||||.|.|||||
Mouse   814 KS-VELDSDDGGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKA 877

  Fly   899 LETALKEAKEGAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQ-------GAIAIR 956
            ||:|||||||.|||||||||.||||||||||.|::.||...||||||||.|.       ...|:|
Mouse   878 LESALKEAKENAMRDRKRYQQEVDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAVR 942

  Fly   957 GGGAVGGPS 965
            |||  ||.|
Mouse   943 GGG--GGSS 949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KhcNP_476590.1 KISc_KHC_KIF5 10..333 CDD:276820 248/322 (77%)
KISc 12..340 CDD:214526 251/327 (77%)
Apolipoprotein 595..744 CDD:279749 70/156 (45%)
Kif5cNP_032475.2 KISc_KHC_KIF5 6..327 CDD:276820 248/322 (77%)
KISc 8..334 CDD:214526 251/327 (77%)
Microtubule-binding 174..315 119/140 (85%)
Lebercilin 605..798 CDD:292252 89/192 (46%)
BAR 636..817 CDD:299863 89/181 (49%)
Globular 859..956 65/93 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..956 20/42 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 643 1.000 Domainoid score I164
eggNOG 1 0.900 - - E2759_KOG0240
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1143 1.000 Inparanoid score I212
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52972
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000669
OrthoInspector 1 1.000 - - otm42515
orthoMCL 1 0.900 - - OOG6_100344
Panther 1 1.100 - - O PTHR24115
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2595
SonicParanoid 1 1.000 - - X952
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.860

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