DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and kif5c

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_002935337.3	Gene:	kif5c / 100493873	XenbaseID:	XB-GENE-977474	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	968	Identity:	586/968 - (60%)
Similarity:	738/968 - (76%)	Gaps:	41/968 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            |||.||||:|||||||.:|.:.|.||:..|..  |:..:....|.|:|||||..|.:||.||:..
Frog     4 PAECSIKVMCRFRPLNKAEIQRGDKFIPVFKG--EDTVVVGPSKPYVFDKVFPSNTTQEHVYSAC 66

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHI 137
            ||.||.|||.||||||||||||||||||||||.:.|....||||||.:|||:|||:|:.||||||
Frog    67 AKQIVKDVLDGYNGTIFAYGQTSSGKTHTMEGKLHDHQMMGIIPRIAHDIFDHIYSMDENLEFHI 131

  Fly   138 KVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVT 202
            ||||:|||:|||||||||||.||:|||||||||:|||.|||||||||:|.:||:|||:|||:|||
Frog   132 KVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPFVKGCTERFVSSPEEVMDVIDEGKANRHVAVT 196

  Fly   203 NMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSA 267
            |||||||||||:||||:||||:|.:|||||||||||||||||||||||||.||||||||||||||
Frog   197 NMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSA 261

  Fly   268 LGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKT 332
            |||||||||:|.|||:||||||:|||||:|||||.||||:|||||:.|||:||||||.||:||||
Frog   262 LGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIIICCSPSIFNEAETKSTLMFGQRAKT 326

  Fly   333 VKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDLMEAS 397
            :||.|.||.||||||||::|||||:|...||..::.||:||.|||.||.|..:||.:.:|
Frog   327 IKNTVSVNLELTAEEWKKKYEKEKDKTKSLKNIIQHLEMELNRWRRGEAVPVDEQTSAKD----- 386

  Fly   398 TPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQYA 462
            ...|| ....|...:..|..        :.:::..|:.:...:...||.||||||:|||||||..
Frog   387 QKTLE-PCDNTPVIDNGLVG--------ATNISSEEKKKYDEDIASLYGQLDDKDDEINQQSQLI 442

  Fly   463 EQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEIDN 527
            |:||:|:::||||:|:.||:||.:|.|:.|:|.||::||:||||||||||||||||||||||:::
Frog   443 EKLKQQMLDQEELLASTRRDYEKIQEELTRLQIENDAAKDEVKEVLQALEELAVNYDQKSQEVED 507

  Fly   528 KNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSI 592
            |.|..:.|:|||.||.:.......||.||:::|:||:||.||:|..||:||||:|..:...
Frog   508 KTKLNEQLSEELTQKTTNLTVTQRELSQLQELSNHQRKRTTEILNLLLKDLGEIGGIVGTN---- 568

  Fly   593 DLK-MSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEY 656
            |:| ::.:.|.    :||:||||||:|||||:|.|::..|...:|:.|.::|:||:..||:|...
Frog   569 DVKTLAEVNGV----IEEEFTMARLYISKMKSEVKSLVNRSKQLESAQIEANRKINASEKELAAC 629

  Fly   657 RLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAEEKQR------- 714
            :||.|||||::|||.:.|:..|.::|.|||..|:|.||.|:|.|.|.:..|:.::|::
Frog   630 QLLSSQHEAKIKSLTDYMQNMEQRRRQLEEAQDALNEELARLHAQEKMHKVSFQDKEKEHLTRLQ 694

  Fly   715 -AEELRSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQE 778
             |||::...:.||:..||||.:|:|.|||||..||..:|::||::|||.|...::|:||||::.|
Frog   695 DAEEIKKTLEQQMESHREAHQKQLSRLRDEIEEKQKMIDDLKDLNQKLQLQLDKLTSDYEKLKTE 759

  Fly   779 DAEKSSELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEE 843
            :.::..:||.::|.||:|||:|:||||||:|||:||||||||||||:|||..|::|. |..:|:.
Frog   760 EEQREEDLQKLVLLNEKREQSREDLKGLEETVARELQTLHNLRKLFIQDLALRVQKR-VELDSDN 823

  Fly   844 DGGSLAQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKE 908
            .|||.|||||||||||||:||||||||||||||||||||||||||||.|.|||||||.|||||||
Frog   824 GGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALEGALKEAKE 888

  Fly   909 GAMRDRKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQ-------GAIAIRGGG 959
            .|||||:|||.||||||||||.|::.||.|.||||||||.|.       ...:|||||
Frog   889 NAMRDRRRYQQEVDRIKEAVRAKNIARRAPSAQIAKPIRPGHYPASSPTAVHSIRGGG 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	243/322 (75%)
		KISc	12..340	CDD:214526	246/327 (75%)
		Apolipoprotein	595..744	CDD:279749	66/157 (42%)
kif5c	XP_002935337.3	KISc_KHC_KIF5	6..327	CDD:276820	243/322 (75%)
		COG4372	469..>673	CDD:226809	105/211 (50%)
		SMC_prok_B	580..>912	CDD:274008	195/332 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	641	1.000	Domainoid score	I165
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I222
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm47617
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080