Protein Alignment Khc and kif3b

DIOPT Version :10

• Sequence 1: NP_476590.1
• Gene: Khc / 36810
• FlyBaseID: FBgn0001308
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001093615.1
• Gene: kif3b / 100101641
• ZFINID: ZDB-GENE-050119-3
• Length: 775
• Species: Danio rerio
• Alignment Length: 805
• Identity: 260/805 - (32%)
• Similarity: 396/805 - (49%)
• Gaps: 133/805 - (16%)

  Fly     9 AEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAG----------KVYLFDKVFKPNA 63
            :.:|:|||.|.||:|:.|..|....||..  :|:...:::..          ||:.||.|:..|:
Zfish     6 SSESVKVVVRCRPMNEKERVANFNRVVSV--DVKLGQVAVCNPRGASSHEHPKVFTFDSVYDWNS 68

  Fly    64 SQEKVYNEAAKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYA 128
            .|.::|:|..:.:|..||.|:||||||||||.:|||:|||||..|..::|:||.....||.||..
Zfish    69 KQMELYDETFRPLVDSVLFGFNGTIFAYGQTGTGKTYTMEGVRNDPERRGVIPNSFEHIFTHISC 133

  Fly   129 MEVNLEFHIKVSYYEIYMDKIRDLLDVSKV-NLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEE 192
            .: |.::.::.||.|||.::|||||...:. .|.:.|..:...|||..:.....|..::..|:..
Zfish   134 SQ-NQQYLVRASYLEIYQEEIRDLLSKDQARRLELKERPDTGVYVKDLSSFVTKSVREIEHVMNV 197

  Fly   193 GKSNRHIAVTNMNEHSSRSHSVFLINVKQENL----ENQKKLSGKLYLVDLAGSEKVSKTGAEGT 253
            |..||.:..|||||||||||::|:|.::...|    ||..:: |||.||||||||:.:||||:|.
Zfish   198 GNQNRSVGATNMNEHSSRSHAIFVITIECSELGPDGENHIRV-GKLNLVDLAGSERQTKTGAQGE 261

  Fly   254 VLDEAKNINKSLSALGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNES 318
            .|.||..||.||||||||||||.||..||||||||||||:||:||||||||.:|....|||:|..
Zfish   262 RLKEATKINLSLSALGNVISALVDGRSTHIPYRDSKLTRLLQDSLGGNARTVMVANIGPASYNVE 326

  Fly   319 ETKSTLDFGRRAKTVKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEK----LEIELARWRAG 379
            ||.:||.:..|||.:||...|||: ..:...|.::   |:.||||.::||    ......|.|.|
Zfish   327 ETLTTLRYANRAKNIKNKPRVNED-PKDALLREFQ---EEIARLKEQLEKRSGRKRRRRRRRRVG 387

  Fly   380 ETVKAEEQINMEDLMEASTPNLEVEAAQTAAAEAA---------LAAQRTALANMSASVAVNEQA 435
            |  ..||..:.||..:....:.:.|....|....|         |..:|.|:        :.:.:
Zfish   388 E--GGEEFEDGEDEEDDDDDDEDEEEGVDADKNIADYWHEQQEKLEKERRAI--------MEDHS 442

  Fly   436 RLATECERLYQQLDDKDEEINQQSQYAEQL--KEQVMEQEELIA------NARREYETLQSEMAR 492
            .:|.|.:||.::.:.|..:::::.:.:|.|  |.:.||.:.|:.      :...:.:.|:.:
Zfish   443 LVAEEKQRLLKEKERKMTDLHKEKEASEMLTAKVKAMESKLLVGGKNIVDHTNEQQKVLELK--- 504

  Fly   493 IQQENESAKEEVKEVLQALE-------ELAVNYDQKSQEIDNKNKDIDALNEELQQKQSVFNAAS 550
             :||....|...:|:.|.:|       ||...|....||:|.|.|.:..|..:||..:|
Zfish   505 -RQEIAEQKRREREMKQEMECRDEETLELKETYSSLQQEVDIKTKKLKKLFSKLQSVKS------ 562

  Fly   551 TELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESSIDLKMSALAGTDASKVEEDFTMAR 615
             |:|..:|.....::.:.:....|.|:| ::...|.  |:.|.::......|.|:..|||.....
Zfish   563 -EIQDAQDEHVKYRQELEQTQNELTREL-KLKHLII--ENFIPMEEKNKIVTRATFDEEDDLWKM 623

  Fly   616 LFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEYRLLISQHEARMKSLQESMR----- 675
            ..|::::                  :|:.::.:.......||..:||| |||..|   ||
Zfish   624 TPITRIQ------------------NSDHQMMKRPVSAVGYRRPLSQH-ARMAML---MRPDVRY 666

  Fly   676 EAEN--------KKRTLEEQ-------------IDSLREE----------CAKLKAAEHVSAVNA 709
            :|||        ..||.::.             .|:||||          .|.|.::..:||..|
Zfish   667 KAENILLLELDLPSRTTKDYEGPVIAPKVAAALEDALREEDEIQVDASGFHASLGSSPGLSASAA 731

  Fly   710 EEKQRAEELRSMFDSQMDELREAHT 734
            ...::.:..|.....::.....||:
Zfish   732 GFSKKPKSGRPKTGKKVSTPTSAHS 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	158/337 (47%)
		Smc	<341..>807	CDD:440809	98/458 (21%)
		Khc_CBD_cc	856..925	CDD:467880
kif3b	NP_001093615.1	KISc_KIF3	15..341	CDD:276822	154/329 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..419		11/48 (23%)
		Mplasa_alph_rch	<425..>611	CDD:275316	42/207 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..775		8/41 (20%)