DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc and kif5b

DIOPT Version :9

Sequence 1:	NP_476590.1	Gene:	Khc / 36810	FlyBaseID:	FBgn0001308	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001122126.1	Gene:	kif5b / 100038146	XenbaseID:	XB-GENE-854737	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	962	Identity:	596/962 - (61%)
Similarity:	744/962 - (77%)	Gaps:	37/962 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PAEDSIKVVCRFRPLNDSEEKAGSKFVVKFPNNVEENCISIAGKVYLFDKVFKPNASQEKVYNEA 72
            |||.||||:||||||||||...|.|:|.||..   |:.:.:|.|.|:||:||:.|.|||:|||..
Frog     4 PAECSIKVMCRFRPLNDSEVTRGDKYVAKFQG---EDTVVMASKPYVFDRVFQSNTSQEQVYNAC 65

  Fly    73 AKSIVTDVLAGYNGTIFAYGQTSSGKTHTMEGVIGDSVKQGIIPRIVNDIFNHIYAMEVNLEFHI 137
            ||:||.|||.||||||||||||||||||||||.:.|....|||||||.||||:||:|:.||||||
Frog    66 AKAIVKDVLDGYNGTIFAYGQTSSGKTHTMEGKLHDPDGMGIIPRIVQDIFNYIYSMDENLEFHI 130

  Fly   138 KVSYYEIYMDKIRDLLDVSKVNLSVHEDKNRVPYVKGATERFVSSPEDVFEVIEEGKSNRHIAVT 202
            ||||:|||:|||||||||||.||||||||||||||||.|||||.||::|.:.|:|||||||:|||
Frog   131 KVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVT 195

  Fly   203 NMNEHSSRSHSVFLINVKQENLENQKKLSGKLYLVDLAGSEKVSKTGAEGTVLDEAKNINKSLSA 267
            |||||||||||:|||||||||.:.::||||||||||||||||||||||||.|||||||||||||:
Frog   196 NMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSS 260

  Fly   268 LGNVISALADGNKTHIPYRDSKLTRILQESLGGNARTTIVICCSPASFNESETKSTLDFGRRAKT 332
            |||||||||:|: .:|||||||:|||||:|||||.||||||||||:::||:|:||||.||:||||
Frog   261 LGNVISALAEGS-VYIPYRDSKMTRILQDSLGGNCRTTIVICCSPSAYNEAESKSTLLFGQRAKT 324

  Fly   333 VKNVVCVNEELTAEEWKRRYEKEKEKNARLKGKVEKLEIELARWRAGETVKAEEQINMEDL-MEA 396
            :||.||||.|||||:||::|||||||...|:..|:.||.||.|||.||||..|||.:.|.. |:|
Frog   325 IKNTVCVNVELTAEQWKKKYEKEKEKTKSLRSTVQWLENELNRWRKGETVPIEEQYDKEKANMDA 389

  Fly   397 STPNLEVEAAQTAAAEAALAAQRTALANMSASVAVNEQARLATECERLYQQLDDKDEEINQQSQY 461
            ...:..|...:.|.         |..||.:.:    |:.:...|..:||:||||||||||||||.
Frog   390 FVVDNFVNNEKPAV---------TLAANFTDA----ERRKCEEEVTKLYKQLDDKDEEINQQSQL 441

  Fly   462 AEQLKEQVMEQEELIANARREYETLQSEMARIQQENESAKEEVKEVLQALEELAVNYDQKSQEID 526
            .|:||:|:::||||:|:.||:.:.:|:|:.|:|.||:::||||||||||||||||||||||||::
Frog   442 VEKLKQQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVE 506

  Fly   527 NKNKDIDALNEELQQKQSVFNAASTELQQLKDMSSHQKKRITEMLTNLLRDLGEVGQAIAPGESS 591
            :|:|:.|.|:|||.||..:.::..:|||:||:|::|||||.|||:|:||:||.|:|.|:...
Frog   507 DKSKEYDILSEELNQKSVILSSIDSELQKLKEMTNHQKKRATEMMTSLLKDLAEIGIAVGGN--- 568

  Fly   592 IDLKMSALAGTDASKVEEDFTMARLFISKMKTEAKNIAQRCSNMETQQADSNKKISEYEKDLGEY 656
             |.|...::|    .::|:||:|||:|||||:|.|.:.:||..:|..|::||||:.|.||:|...
Frog   569 -DGKQPEVSG----MIDEEFTVARLYISKMKSEVKTMVKRCKQLEGTQSESNKKMEENEKELAAC 628

  Fly   657 RLLISQHEARMKSLQESMREAENKKRTLEEQIDSLREECAKLKAAEHVSAVNAE---EKQRAEEL 718
            :|.||||||::|||.|.::..|.|||.|||.:|||.||..||:|.|.|..:..|   :.|.|.|:
Frog   629 QLRISQHEAKIKSLTEYVQNVEQKKRHLEESVDSLNEELVKLRAQEKVHEMEKEHLNKVQTATEV 693

  Fly   719 RSMFDSQMDELREAHTRQVSELRDEIAAKQHEMDEMKDVHQKLLLAHQQMTADYEKVRQEDAEKS 783
            :...:.|:...||.|.:|:|.|||||..|:..:.|::|.:||::|..:::..::||::..|.|||
Frog   694 KHAVEEQIQSHRETHQKQLSALRDEIETKEKVITELQDQNQKMVLEQERLRVEHEKLKYADQEKS 758

  Fly   784 SELQNIILTNERREQARKDLKGLEDTVAKELQTLHNLRKLFVQDLQQRIRKNVVNEESEEDGGSL 848
            .:|..:.:..:||||||:||||||:||||||||||||||||||||..|::|: ...:|::.|||.
Frog   759 KKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLTTRVKKS-AEMDSDDTGGSA 822

  Fly   849 AQKQKISFLENNLDQLTKVHKQLVRDNADLRCELPKLEKRLRCTMERVKALETALKEAKEGAMRD 913
            |||||||||||||:||||||||||||||||||||||||||||.|.|||||||:|||||||.|.||
Frog   823 AQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRD 887

  Fly   914 RKRYQYEVDRIKEAVRQKHLGRRGPQAQIAKPIRSGQGAI-------AIRGG 958
            |||||.||||||||||.|::.|||..||||||||.||...       |||||
Frog   888 RKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPNAIRGG 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc	NP_476590.1	KISc_KHC_KIF5	10..333	CDD:276820	244/322 (76%)
		KISc	12..340	CDD:214526	248/327 (76%)
		Apolipoprotein	595..744	CDD:279749	68/151 (45%)
kif5b	NP_001122126.1	KISc_KHC_KIF5	6..325	CDD:276820	244/322 (76%)
		Smc	<409..792	CDD:224117	193/394 (49%)
		COG4372	709..>914	CDD:226809	136/205 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	641	1.000	Domainoid score	I165
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55829
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I222
OMA	1	1.010	-	-		QHG52972
OrthoDB	1	1.010	-	-		D1334528at2759
OrthoFinder	1	1.000	-	-		FOG0000669
OrthoInspector	1	1.000	-	-		otm47617
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X952
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080