DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ITGAD and if

DIOPT Version :9

Sequence 1:	XP_011544137.1	Gene:	ITGAD / 3681	HGNCID:	6146	Length:	1190	Species:	Homo sapiens
Sequence 2:	NP_001162777.1	Gene:	if / 32661	FlyBaseID:	FBgn0001250	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	1159	Identity:	254/1159 - (21%)
Similarity:	395/1159 - (34%)	Gaps:	410/1159 - (35%)

- Green bases have known domain annotations that are detailed below.

Human     5 TVLLLSVLASYHGFNLDVEEPTIFQEDAGG-FGQSVVQ------FGGSR----LVVGAPLEVVA- 57
            :::||.:..|.||:|:|:.....|::.:.. ||.|:..      |.|::    |:||||....:
  Fly    19 SLILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSR 83

Human    58 ----ANQTGRLYDCAAATGMCQPIPL-------HIRPEAVNMS----LGLTLAASTNGSRLLACG 107
                ..:.|.::.|:.....|:.:|.       ::..|.|:..    ||.|:|...:...::||.
  Fly    84 YQQGVTEAGGVFKCSLNDDDCKLVPFDSKGNNRNVDKEVVDRKSYQWLGATVATGRDSDLVVACA 148

Human   108 PTLHRVCGENSYSKGSCLLLGSRWEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGF 172
            |
  Fly   149 P---------------------------------------------------------------- 149

Human   173 VQAVMGQFEGTDTLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPIVQLKGLTFTATGILTVVTQ 237
                              :|     :..|.|     ||:...:||:    |..||:
  Fly   150 ------------------RY-----VFHTMT-----PSRAFRIDPV----GTCFTS--------- 173

Human   238 LFHHKNGARKSAKKILIVITDGQKYKDPLEYSDVIPQAEKAGIIRYAIGVGHAFQGPTARQELNT 302
                                                               |.|
  Fly   174 ---------------------------------------------------HNF----------- 176

Human   303 ISSAPPQDHVFKVDNFAALGSIQKQLQEKIYAVEGTQSRASSSFQHEMSQEGFSTALTMSLPSPG 367
                                       |:.|.|...::......:....|.|||.|:.
  Fly   177 ---------------------------EEFYEVSPCRTNNWGYHRQGSCQAGFSAAIN------- 207

Human   368 ILSSQDGLFLGAVGSFSWSGGAFLYPPNMSPTF-------------------------INMSQEN 407
              .:...||:||.||:.|.|..:..||:....|                         :..:.|:
  Fly   208 --GNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFSTSES 270

Human   408 VDMR-DSYLGYSTELALWKG--VQNLVLGAPRYQHTGKAVIFTQVSRQWRKK--AEVTGTQIGSY 467
            ..:. |||||||.....:.|  .:::.:|.||    |..::...|..:|...  ..:||.|||.|
  Fly   271 ASVNDDSYLGYSMVTGDFDGDRSEDVAIGMPR----GGNLVGRIVVNRWNMANIFNITGRQIGEY 331

Human   468 FGASLCSVDVDSDGSTDLILIGAPHYY--EQTRG----GQVSVCPLPRG---QRVQWQCDAVLRG 523
            ||.||.:.|||.||..|| |||||.|.  :...|    |:|.:  |.:|   :..:|..:.:..|
  Fly   332 FGYSLATSDVDGDGLDDL-LIGAPMYTDPDNVEGKYDVGRVYI--LLQGGPTEEKRWTTEHIRDG 393

Human   524 EQGHPWGRFGAALTVLGDVNEDKLIDVAIGAPGE-QENRGAVYLFHGASESGISPSHSQRIASSQ 587
            .  |..||||.|||.|||||.|...|.|:|||.: .|.||.||:||| |..|.....||.|.|.|
  Fly   394 Y--HSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHG-SPMGPLAKPSQIIKSEQ 455

Human   588 L---SPRLQYFGQALSGGQDLTQDGLMDLAVGA--RGQVLLLRSLPVLKVGVAMRF-------SP 640
            |   :|..:.||.|||||.|:..:...||||||  ..||.:.:|.||..|.....|       |.
  Fly   456 LVEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISL 520

Human   641 VEVAKAVYRCWEEKPSALEAGDATVCLTIQKSSLDQLGDIQSSVRFDLA--LDPGRLTSRAIF-- 701
            .:.:..:.|..::.|..|    .|.|.:.....|.:..|      ||::  ||..:|.:..:|
  Fly   521 DDRSCQLVRDHKKVPCML----LTTCWSYTGRYLPEQLD------FDVSWLLDAKKLLNPRMFFL 575

Human   702 -NETKNPTLTRRKTLGLGI---HC--ETLKLLLPDCVEDVVSPIILHLNFSLVREPIPSPQNLR- 759
             :|.||   .|.:|:.|..   :|  ||:.||  |.|:|.::|:.:...::| |...|....:|
  Fly   576 RDEGKN---IRNQTIRLNYGQKYCLNETVYLL--DKVQDKLTPLEVEARYNL-RSSRPLDPMVRH 634

Human   760 ------PVLAVGSQDLFTASLPFEKNCGQDGLCEGDLGVTLSFSGLQTLTVGSSLELNVIVTVWN 818
                  ||:....:.:...::..:||||.|.:||.||  .|..|.:.....||...|.:.|.:.|
  Fly   635 RRSILEPVIDQNREIVLRDAINIQKNCGPDNICEPDL--KLKVSTVDKYLFGSPEPLVIEVFISN 697

Human   819 AGEDSYGTVVSLYYPAGLSHRRVSGAQKQPHQSALRLACETVPTEDEGLRSSRCSVNHPIFHEGS 883
            ..||::.....:..|..|..|::   |:...:....:.|.  |...|...:.:|.:.:|: ..|.
  Fly   698 TNEDAFEAAFYMVTPPDLQFRKL---QQLGEKKDTPITCS--PPTPENNHTLKCDIGNPL-ESGK 756

Human   884 NGTFIVTFDVSYKATLGDRMLMRASASSENNKASSSKATFQLELPVKYAVYTMISRCPVPGLPLG 948
            ...|                  :.|...|....|||...|.
  Fly   757 IAHF------------------KISLVPEEKYGSSSSYDFY------------------------ 779

Human   949 PLAFLYAWQEESTKYFNFATSDEKKMKEAEHRYRVNNLSQRDLAISINFWVPVLLNGVAVWDVVM 1013
                   |:..||..       ||...|.:::.|.          |:..||          |..:
  Fly   780 -------WEANSTNL-------EKPGSEYDNKIRQ----------SVGIWV----------DTDL 810

Human  1014 EAPSQSLPCVSERKPPQHSDFLTQISRSPMLDCSIADCLQFRCDVPSFSVQEEL 1067
            :....|||.....|...:.: |...::...:...:....:.|.:.||...:.|:
  Fly   811 DIKGTSLPDYQLYKADDYKE-LENATKEDDIGPQVVHIYEIRNNRPSIIEEAEV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ITGAD	XP_011544137.1	vWA_integrins_alpha_subunit	149..324	CDD:238746	12/174 (7%)
		Int_alpha	464..>506	CDD:214549	23/47 (49%)
		Int_alpha	528..583	CDD:214549	30/55 (55%)
		Int_alpha	593..>625	CDD:214549	16/33 (48%)
		Integrin_alpha2	628..>933	CDD:285619	74/328 (23%)
		Integrin_alpha	1153..1167	CDD:278771
if	NP_001162777.1	Int_alpha	46..110	CDD:214549	14/63 (22%)
		Int_alpha	275..>316	CDD:214549	13/44 (30%)
		Int_alpha	398..451	CDD:214549	30/53 (57%)
		Int_alpha	466..>497	CDD:214549	16/30 (53%)
		Integrin_alpha2	499..893	CDD:285619	95/466 (20%)
		DUF2756	<1120..1178	CDD:298627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142040
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740