DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment csul and Prmt5

DIOPT Version :9

Sequence 1:	NP_477184.1	Gene:	csul / 36809	FlyBaseID:	FBgn0015925	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	NP_001102337.2	Gene:	Prmt5 / 364382	RGDID:	1309053	Length:	637	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	243/587 - (41%)
Similarity:	347/587 - (59%)	Gaps:	24/587 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EPHESDP---TYPATILSGSDWNSKVIFTMSD-VNVDSPNDKLREHAKEVFMRDVAWAEHLQNVG 102
            ||.::.|   |....:|||.|||:.::..:|. ::.||..:|:|.:::...::::.:..:| .:.
  Rat    57 EPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIHPDSKVEKIRRNSEAAMLQELNFGAYL-GLP 120

  Fly   103 NLMVRLRGPENENLASIVLAKTKDDFPSGNWFIQVPITNPELA---TFEHRKDATAEEVAEAESN 164
            ..::.|...:|.|||.::.........|..::::||:..||..   ..|:...|..||.:..|..
  Rat   121 AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDVIENAPTAHTEEYSGEEKT 185

  Fly   165 DPWNWWNNLRMVTKHSTKVKVVIELNDADRPSKETVRRWLGEPIEAIIIPSSLFVRNRSNYCVLK 229
              |.||:|.|.:..:|.::.|.:|:. ||.||...:.|||||||:|.|:|:|:|:.|:..:.||.
  Rat   186 --WLWWHNFRTLCDYSKRIAVALEIG-ADLPSSHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLS 247

  Fly   230 KEWQLIVGHFISVRANIIIS-TN-PNDKALCQYADYVNKLIND----NCDKHMLNSYENMLEIPL 288
            |..|.::...:.:....||: || .::|..|.|..|:..|..:    |..:.....||:.|:.||
  Rat   248 KMQQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPL 312

  Fly   289 QPLCDNLDTYTYEVFETDPVKYKLYQDAVQAALLDRVSAAEAKTKLTVVMLLGGGRGPLARAVFN 353
            |||.|||::.||||||.||:||..||.|:...|||||...|.:|.:.|:|:||.|||||..|...
  Rat   313 QPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKETNVQVLMVLGAGRGPLVNASLR 377

  Fly   354 AAELTKRKVRLYIIEKNPNAIRTLSNMVKTLWADKDVHIFSKDMRDFSPPELADIMVSELLGSFG 418
            ||:..:|::|||.:||||||:.||.|.....|..: |.:.|.|||::..||.|||:||||||||.
  Rat   378 AAKQAERRIRLYAVEKNPNAVVTLENWQFEEWGSQ-VTVVSSDMREWVAPEKADIIVSELLGSFA 441

  Fly   419 DNELSPECLDGALKLLKPDGISIPYKSTSYINPLMSAVLHQNV--CQLLPTYP--AFDYGYVSLL 479
            ||||||||||||...||.||:|||.:.||::.|:.|:.|:..|  |:.....|  .|:..||..|
  Rat   442 DNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRL 506

  Fly   480 KNIYHIDEPQALFEFVHPNRAENIDNTRCKTVSFKVNKDCVLHGIGGYFDTHLYKDICLSINPLT 544
            .|.:.:..||..|.|.||||...|||.|..|:.|.|..:.||||..|||:|.||:||.|||.|.|
  Rat   507 HNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYRDITLSIRPET 571

  Fly   545 HTPGMFSWFPMFFATR-PRTLREGQTISIQFWRCVDATKVWYEWQVVNSPDDWEHHNTRGTGYNM 608
            |:||||||||:||..: |.|:.|||.|.::||||.::.|||||| .|.:|.....||..|..|.:
  Rat   572 HSPGMFSWFPIFFPIKQPITVHEGQNICVRFWRCSNSKKVWYEW-AVTAPVCSSIHNPTGRSYTI 635

  Fly   609 RL 610
            .|
  Rat   636 GL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
csul	NP_477184.1	PRMT5	163..589	CDD:282971	205/436 (47%)
csul	NP_477184.1	SAMBD	165..442	CDD:293555	131/282 (46%)
Prmt5	NP_001102337.2	PRMT5_TIM	37..290	CDD:407398	69/236 (29%)
		PRMT5	295..464	CDD:398725	92/169 (54%)
		PRMT5_C	468..635	CDD:407399	78/167 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341545
Domainoid	1	1.000	185	1.000	Domainoid score	I3304
eggNOG	1	0.900	-	-		E1_KOG0822
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4454
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1660
OMA	1	1.010	-	-		QHG54770
OrthoDB	1	1.010	-	-		D205217at33208
OrthoFinder	1	1.000	-	-		FOG0004858
OrthoInspector	1	1.000	-	-		oto97858
orthoMCL	1	0.900	-	-		OOG6_101720
Panther	1	1.100	-	-	LDO	PTHR10738
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3428
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770