Protein Alignment csul and skb1

DIOPT Version :10

• Sequence 1: NP_477184.1
• Gene: csul / 36809
• FlyBaseID: FBgn0015925
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_595936.2
• Gene: skb1 / 2540099
• PomBaseID: SPBC16H5.11C
• Length: 625
• Species: Schizosaccharomyces pombe
• Alignment Length: 614
• Identity: 194/614 - (31%)
• Similarity: 290/614 - (47%)
• Gaps: 97/614 - (15%)

  Fly    44 HESDPTYPATILSGSDWNSKVIFTMSDVNVDSPNDKLREHAKEVFMRDVAWAEHLQNVGNLMVRL 108
            |..:..:....|| |.|          :.:||.:..:.:.::||.:::.::|.:   .|...:.|
pombe    61 HPEENVHKVVGLS-SAW----------LELDSEDTLIADRSEEVLLKEASYASY---CGLSSIIL 111

  Fly   109 RGPEN-------ENLASIVLAKTKDDFPSGNWFIQVPITNPELATFEHRKDATAEEVAEAESNDP 166
            .||.:       ....|..|..|.    :..:.:|:.|.:.....||                 .
pombe   112 NGPTSPMNVMRYARAVSSALNSTM----NLKFLVQLAIESGHEDYFE-----------------T 155

  Fly   167 WNWWNNLRMVTKHSTKVKVVIELNDADRPSKETVRRWLGEPIEAIIIPSSLFVRNRSNYCVLKKE 231
            |..|:.:|....:..::||.:||..|..|..|.|.||..||||.|.:....||.|.:.|.||.::
pombe   156 WKMWDTIRSACGYHPRLKVALELPPACSPPIELVNRWYAEPIEMITMSCMAFVPNPNGYPVLGRK 220

  Fly   232 WQLIVGHFISVRANIIISTNPNDKALCQYADY------------VNKLINDNCDKHMLNSYENML 284
            .:.|...::.:...|::..|...:.:....||            ...|:.|..|     ||::.|
pombe   221 LRAIYALYLRLNPRILLWDNDAPEKIGDSPDYSIYMKHLFDSQPPAPLVEDLAD-----SYKDYL 280

  Fly   285 EIPLQPLCDNLDTYTYEVFETDPVKYKLYQDAVQAALLDRVSAAEAKTKLTVVMLLGGGRGPLAR 349
            ::|||||..||:..|||:||.|||||..|:.|:.:||:||     .::.:|.:.::|.|||||..
pombe   281 QVPLQPLSYNLENITYEIFERDPVKYAQYEQAIFSALMDR-----DESSVTRIAVVGAGRGPLVD 340

  Fly   350 AVFNAAELTKRKVRLYIIEKNPNAIRTLSNMVKTLWADKDVHIFSKDMRDFSPPELADIMVSELL 414
            ....||..:.|.|.:..:||||||...|....:..||.|...:|. |||.::|....||:|||||
pombe   341 CALRAAISSSRTVDMIALEKNPNAFSMLLMRNRQDWAGKVTLVFG-DMRTWNPDYKIDILVSELL 404

  Fly   415 GSFGDNELSPECLDGALKLLKPD-GISIPYKSTSYINPLMSAVLHQNVCQLLPTYP-AFDYGYVS 477
            ||.||||||||||||...:|..: ||.||....||:.|:||..|......:  ..| ||:..||.
pombe   405 GSMGDNELSPECLDGVQHVLDEETGICIPSSYISYVTPIMSPKLWSEARNM--NDPNAFERQYVV 467

  Fly   478 LLKNIYHI---DE--PQALFEFVHPNR-----AENIDNTRCKTVSFKVNKDCVLHGIGGYFDTHL 532
            |:.:...:   ||  .|:|:.|.|||:     .:|:.|.|..:|.|:.:...:|||..|||:..|
pombe   468 LMNSFDFLAADDEFRFQSLWSFHHPNKDSEVYTKNLHNKRFASVRFQASSPGILHGFAGYFEATL 532

  Fly   533 YKDICLSINPLT---HTPGMFSWFPMFF-ATRPRTLREGQTISIQFWRCVDATKVWYEW------ 587
            ||||.|||.|.|   .:|.||||||::. ..:|..:.|...:....||..|..:||:||
pombe   533 YKDISLSIMPATMEAKSPDMFSWFPIYMPIKKPMYVPENSQLEFHMWRLTDGMRVWFEWCANAYL 597

  Fly   588 ------QVVNSPDDWEHHNTRGTGYNMRL 610
                  |:..|  ..|.||..|..::..:
pombe   598 VLRNGSQIKLS--STEVHNISGKAFSCNM 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
csul	NP_477184.1	PRMT5_TIM	26..269	CDD:435840	51/243 (21%)
		PRMT5	271..441	CDD:428356	77/170 (45%)
		PRMT5_C	444..608	CDD:435841	63/190 (33%)
skb1	NP_595936.2	PRMT5_TIM	24..262	CDD:435840	50/235 (21%)
		PRMT5	267..432	CDD:428356	79/175 (45%)
		PRMT5_C	435..622	CDD:435841	63/190 (33%)