DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment csul and prmt5

DIOPT Version :9

Sequence 1:	NP_477184.1	Gene:	csul / 36809	FlyBaseID:	FBgn0015925	Length:	610	Species:	Drosophila melanogaster
Sequence 2:	XP_002941557.1	Gene:	prmt5 / 100145788	XenbaseID:	XB-GENE-975034	Length:	633	Species:	Xenopus tropicalis

Alignment Length:	590	Identity:	234/590 - (39%)
Similarity:	346/590 - (58%)	Gaps:	29/590 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EPHESDP---TYPATILSGSDWNSKVIFTMSD-VNVDSPNDKLREHAKEVFMRDVAWAEHLQNVG 102
            ||.:|.|   |....:|||.|||:.::..:|| :..||....:|:.::....:::.::.:| .:.
Frog    52 EPAKSRPGPQTRSDLLLSGRDWNTLIVGKLSDWIKTDSKVSGIRKTSEAALQQELNFSAYL-GLP 115

  Fly   103 NLMVRLRGPENENLASIVLAKTKDDFPSGNWFIQVPITNPELATFEHRKDATAEE-VAEAESND- 165
            ..::.|:..:|.||:.:::........|..::::||:..|.    :.|.|....| ::::|.::
Frog   116 AFLIPLKQEDNSNLSRLLINHIHTGHHSTMFWMRVPLMAPN----DLRDDIIENEPLSQSEEDNI 176

  Fly   166 ----PWNWWNNLRMVTKHSTKVKVVIELNDADRPSKETVRRWLGEPIEAIIIPSSLFVRNRSNYC 226
                .|.||:|.|.:..::.:|.:.||:. ||.|:...:.|||||||:|..:|:|:|:.|:..:.
Frog   177 DEERTWIWWHNFRSLCDYNKRVALAIEVG-ADLPNGHIIDRWLGEPIKAAFLPTSIFLTNKKGFP 240

  Fly   227 VLKKEWQLIVGHFISVRANIIIS--TNPNDKALCQYADYVNKLIND----NCDKHMLNSYENMLE 285
            ||.|..|.::.....:....:||  .:.::|..|.|..|:..|..:    |..:.....||:.|:
Frog   241 VLSKVHQRLIFRLFKLEVQFVISGAHHHSEKDFCSYLQYLEYLSQNRPPPNAYEMFAKGYEDYLQ 305

  Fly   286 IPLQPLCDNLDTYTYEVFETDPVKYKLYQDAVQAALLDRVSAAEAKTKLTVVMLLGGGRGPLARA 350
            .|||||.|||::.||||||.|||||..||.||...|||||...|.:|.:.|:|:||.|||||..|
Frog   306 SPLQPLMDNLESQTYEVFEKDPVKYSQYQQAVYKCLLDRVPEEEKETNIQVLMVLGAGRGPLVNA 370

  Fly   351 VFNAAELTKRKVRLYIIEKNPNAIRTLSNMVKTLWADKDVHIFSKDMRDFSPPELADIMVSELLG 415
            ...||:..:||:::|.:||||||:.||.......|..: |.:.|.|||::..||.|||:||||||
Frog   371 SLRAAKQAERKIKVYAVEKNPNAVITLEGWRYEEWGSQ-VTVVSGDMREWKAPEKADIIVSELLG 434

  Fly   416 SFGDNELSPECLDGALKLLKPDGISIPYKSTSYINPLMSAVLHQNV--CQLLPTYP--AFDYGYV 476
            |||||||||||||||...||.||:|||.:.|||:.|:.|:.|:..|  |:.....|  .|:..||
Frog   435 SFGDNELSPECLDGAQHFLKEDGVSIPSEYTSYLAPISSSKLYNEVRACREKDRDPEAQFEMPYV 499

  Fly   477 SLLKNIYHIDEPQALFEFVHPNRAENIDNTRCKTVSFKVNKDCVLHGIGGYFDTHLYKDICLSIN 541
            ..|.|.:.:.:|...|.|:|||:...|||.|...:.::|:.:.||||..||||..||||:.|||.
Frog   500 VRLHNFHQLSDPLPCFTFLHPNKDAVIDNNRYICLQYRVDLNTVLHGFAGYFDAVLYKDVTLSIC 564

  Fly   542 PLTHTPGMFSWFPMFFATR-PRTLREGQTISIQFWRCVDATKVWYEWQVVNSPDDWEHHNTRGTG 605
            |.:|:||||||||:.|..: |..||||.|:.::||||.:..|||||| .|.||.....||..|..
Frog   565 PESHSPGMFSWFPILFPIKQPIPLREGDTVCVRFWRCNNGKKVWYEW-AVTSPVCSAIHNPTGRS 628

  Fly   606 YNMRL 610
            |.:.|
Frog   629 YTIGL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
csul	NP_477184.1	PRMT5	163..589	CDD:282971	197/441 (45%)
csul	NP_477184.1	SAMBD	165..442	CDD:293555	128/287 (45%)
prmt5	XP_002941557.1	PRMT5_TIM	32..286	CDD:375105	63/239 (26%)
		PRMT5	291..460	CDD:368326	93/169 (55%)
		PRMT5_C	464..631	CDD:375106	74/167 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3331
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4454
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1830
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205217at33208
OrthoFinder	1	1.000	-	-		FOG0004858
OrthoInspector	1	1.000	-	-		oto104549
Panther	1	1.100	-	-	LDO	PTHR10738
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3428
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160