DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fidipidine and CCDC93

DIOPT Version :9

Sequence 1:	NP_523760.1	Gene:	fidipidine / 36808	FlyBaseID:	FBgn0025519	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_011509661.1	Gene:	CCDC93 / 54520	HGNCID:	25611	Length:	686	Species:	Homo sapiens

Alignment Length:	615	Identity:	234/615 - (38%)
Similarity:	359/615 - (58%)	Gaps:	55/615 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QVERREDSDATAKEQDTFDILVAAGYYRARIKGLSAFDKVVGGMTWCIECCDYDVDVDLLFHESL 92
            :||.|||.:...|..:..::||||||:||||||||.||||||||||||..|::||||||||.|:.
Human    70 EVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCNFDVDVDLLFQENS 134

  Fly    93 SIGQKIALVEKIVAVLIDMKCPHSLEPHQVQGLEFLAIHPVIQWLVKTSVENRAERGQRLKRFAI 157
            :|||||||.||||:||..|||||.|||||:||::|:.|.||:|||||.::|.:.|.|..::.:::
Human   135 TIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSV 199

  Fly   158 GQFHNHYQYKSDKDNLTKIRLASTNIKAIQDLYGPRRQYERQEAPDD-DDDVSRVRLTLLEYGDP 221
            .||...|....|.|.:.:...|...:..:.::|.|||:|:|.:..:: .|:.||:..||||||..
Human   200 SQFQKTYSLPEDDDFIKRKEKAIKTVVDLSEVYKPRRKYKRHQGAEELLDEESRIHATLLEYGRR 264

  Fly   222 -GPTFRSSAERKADRGPG--------------EKDELDL--EEYLRSLSLIKDDPTGTQKRIDLD 269
             |.:.:|..|:..|:...              |:|||..  |:.::||..........:.|:...
Human   265 YGFSRQSKMEKAEDKKTALPAGLSATEKADAHEEDELRAAEEQRIQSLMTKMTAMANEESRLTAS 329

  Fly   270 PTAR------QELQQHYAEFKLEMETDAQELKSQNQQKRLEAAK-IAMEHKIRRYCKENEQ---- 323
            ...:      .|::|..:|:..:.|..|:|...:....:|...| |::..:|.:..|..|:
Human   330 SVGQIVGLCSAEIKQIVSEYAEKSELSAEESPEKLGTSQLHRRKVISLNKQIAQKTKHLEELRAS 394

  Fly   324 ---LQDAENEQKEKTKEVEDQLNTLNTELKAHKDTQDKADPKLLEKIQSLLQQHEELKKSEAEFK 385
               ||...||.|:...|::.....|:.|..|.:..:.||||.:|:.:::|:..:|.||..|.|||
Human   395 HTSLQARYNEAKKTLTELKTYSEKLDKEQAALEKIESKADPSILQNLRALVAMNENLKSQEQEFK 459

  Fly   386 ESCRTDLANLQLQIDDLESFSAQDAEAQAAALAG----------------------EEQRLKELR 428
            ..||.::..||.:|::|::..|...:.:..: :|                      |:::|.::|
Human   460 AHCREEMTRLQQEIENLKAERAPRGDEKTLS-SGEPPGTLTSAMTHDEDLDRRYNMEKEKLYKIR 523

  Fly   429 LQLAKRNRGIVAIERKLDAIPDRTELAQYQRRFHELHNEMSGKHLETKQYYTLYNTLNDKKRYME 493
            |..|:|||.|..:.||:|.:|.|.||.|||:||.||:.::|..|.||||::||||||:|||.|:|
Human   524 LLQARRNREIAILHRKIDEVPSRAELIQYQKRFIELYRQISAVHKETKQFFTLYNTLDDKKVYLE 588

  Fly   494 KELALLNSICEAYNEGMMSPHGREDFIRQFESIVDGVKSAQDKVRHKYNEERMRRDELNEELQSL 558
            ||::|||||.|.:::.|.||..|:.|:||.|.||:|:|.::.|:..|..|.:||||:||::...|
Human   589 KEISLLNSIHENFSQAMASPAARDQFLRQMEQIVEGIKQSRMKMEKKKQENKMRRDQLNDQYLEL 653

  Fly   559 LELQRQYALAVKQLTRECQRCEQLQLQLRS 588
            ||.||.|...||:...|.::.|.|..::::
Human   654 LEKQRLYFKTVKEFKEEGRKNEMLLSKVKA 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fidipidine	NP_523760.1	KOG2701	42..219	CDD:286803	92/177 (52%)
CCDC93	XP_011509661.1	KOG2701	85..262	CDD:286803	92/176 (52%)
CCDC93	XP_011509661.1	DUF342	<332..490	CDD:302792	41/157 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146040
Domainoid	1	1.000	210	1.000	Domainoid score	I2833
eggNOG	1	0.900	-	-		E1_KOG2701
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10393
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1915
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54367
OrthoDB	1	1.010	-	-		D1091136at2759
OrthoFinder	1	1.000	-	-		FOG0004838
OrthoInspector	1	1.000	-	-		oto89874
orthoMCL	1	0.900	-	-		OOG6_104885
Panther	1	1.100	-	-	LDO	PTHR16441
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3346
SonicParanoid	1	1.000	-	-		X4513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800