DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fidipidine and C16A11.2

DIOPT Version :9

Sequence 1:	NP_523760.1	Gene:	fidipidine / 36808	FlyBaseID:	FBgn0025519	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001021959.1	Gene:	C16A11.2 / 173758	WormBaseID:	WBGene00015815	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	620	Identity:	153/620 - (24%)
Similarity:	256/620 - (41%)	Gaps:	124/620 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DSDATAKEQ---------DTFDILVAAGYYRARIKGLSAFDKVVGGMTWCI-ECCDYDVDVDLLF 88
            |.:|.|.|:         |...:|.|:||:|||:..|:.:||:|||:.|.| .|.|.||.||||:
Worm     2 DLNAAAAEKPETSSNCRNDIIAMLSASGYHRARVSCLNDYDKIVGGIVWAIMRCDDVDVAVDLLY 66

  Fly    89 HESLSIGQKIAL----VEKIVAVLIDMKCPHSLEPHQVQGLEFLAIHPVIQWLVKTSVENRAERG 149
            .||..  |.|.|    .||::..|..::|||.:..||:.||:|||:..|||||:: .|..:..:|
Worm    67 EESED--QNIKLRTEQSEKLIEALKAVQCPHEIATHQISGLDFLALKNVIQWLLR-HVLAQESKG 128

  Fly   150 QRLKRFAIGQFHNHYQYKSD--KDNLTKIRLASTNIKAIQDLYGPRRQYERQEAPDDDDDVSRVR 212
            .:.|.|. ..|..|::::.:  ||....:|...|..:.:       ::::.....:...|   .:
Worm   129 NKFKHFT-EWFSMHHEHRDEALKDFRHHLRRGVTTTRYM-------KRFDNSAMFNLSMD---AK 182

  Fly   213 LTLLEYGDPGPTFRSSAERKADRGPGEKDELDLEEYLRSLSLIKDDPTGTQKRIDLDPTARQELQ 277
            .||.||        ....|..||..|..||.:..:.|:..|..|..||.|.::: :|....:..:
Worm   183 CTLAEY--------VVYSRTGDRLVGFTDETEETDNLKEASTKKHVPTTTVRKM-MDEAVVETFK 238

  Fly   278 QHYAEFKLEMETDAQELKSQNQQKRLEAAK--IAMEHKIRRYCKE-NEQLQDAENEQKEKTKEVE 339
            ......|...|...:|:...|..:||||.:  :..|.::.:..|: ::||.|..|..|.:... .
Worm   239 NDTESIKTSREGMCKEVDELNIPQRLEALESLVIDEAELFQQVKDTHKQLSDRYNTIKNRVVS-N 302

  Fly   340 DQLNTL---NTEL-------KAHKDTQDKADP--KLLEKIQSLLQQHEELKKSEAEFKESCRTDL 392
            ||:.|.   |::|       |..:.||.:||.  ...|....:.|.||.|.:...:.....:...
Worm   303 DQMFTFYNSNSDLDQLAEIVKFFEVTQARADELRACAECDVRMAQNHENLLRQNRDKNGKMQKYC 367

  Fly   393 ANLQLQIDDLESFSAQDAEAQAAALAGEEQRLKELRLQLAKRNRGIVAIERKLDAIPDRTELAQY 457
            ...:..:||.                  .:|:|.:.:..    |.:||::.:||... :|.::.|
Worm   368 VKQREIVDDW------------------AERMKMVYVTC----RDVVALQFRLDRYL-KTLISHY 409

  Fly   458 QRRFHELHNEMSGKHLETKQYYTLYNTLNDKKRYMEKELALLNSICEAYNEGMMSPHGREDFIRQ 522
            ::|..|...|.|....|.|.....:|...|...:..|    :....:...:.::.....:::...
Worm   410 RKRHMEKLLESSELTQEAKTNVIDHNVTIDILTFSAK----IKGFMDEVEKSLVVEPASQEYRDA 470

  Fly   523 FESIVDGV-----------KSAQDK--------------VRHKYNEERMRRDELN---------E 553
            |.|.::.|           |..|||              :|.|..|.....||:.         :
Worm   471 FVSYMNDVRTQLGEYHWKAKLTQDKTLAEKDTLAALRTRIRQKEREVSNTSDEMKRMLKIYESLK 535

  Fly   554 ELQSLLELQR-------QYALAVKQLTRECQRCEQ 581
            |:.||| .||       ||||..::...|.:..|:
Worm   536 EVDSLL-AQREEISPAFQYALDSREAEEEDEEAEE 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fidipidine	NP_523760.1	KOG2701	42..219	CDD:286803	61/192 (32%)
C16A11.2	NP_001021959.1	KOG2701	19..188	CDD:370668	60/182 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158792
Domainoid	1	1.000	95	1.000	Domainoid score	I4663
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I3412
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54367
OrthoDB	1	1.010	-	-		D1091136at2759
OrthoFinder	1	1.000	-	-		FOG0004838
OrthoInspector	1	1.000	-	-		oto20338
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16441
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3346
SonicParanoid	1	1.000	-	-		X4513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.040