DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and KCNH7

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_011510411.1	Gene:	KCNH7 / 90134	HGNCID:	18863	Length:	1204	Species:	Homo sapiens

Alignment Length:	837	Identity:	198/837 - (23%)
Similarity:	344/837 - (41%)	Gaps:	182/837 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 APFAPTATITVEQAATSIPMA-VDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDD 147
            :|.....|..:.|.:...|:. :.|.:.| ..|:|.|.|.|               .|..:....
Human   209 SPSEADDTKALIQPSKCSPLVNISGPLDH-SSPKRQWDRLY---------------PDMLQSSSQ 257

  Fly   148 VDEDDDDEFGASVCEDNPEEAIARAD--HDTQQKQHYQPN------ASDSSYVENGRK------- 197
            :......|   |:|      :|.||.  ||.:....:..|      ||:    :|||.
Human   258 LSHSRSRE---SLC------SIRRASSVHDIEGFGVHPKNIFRDRHASE----DNGRNVKVSRSW 309

  Fly   198 LIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSE 262
            :...|....|.|.|..|..:...:.:..|  |.|...| .||. ..|:|.....|:.:...::.:
Human   310 MAGGPFNHIKSSLLGSTSDSNLNKYSTIN--KIPQLTL-NFSE-VKTEKKNSSPPSSDKTIIAPK 370

  Fly   263 IR----------------GSSVLCNRLSVDPTLQS----HYR-----WLAIVSLAVLYNIIFVVG 302
            ::                |:.||.......|.:..    ||.     |..::.|.|:|..||...
Human   371 VKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPY 435

  Fly   303 RAVFW----------EINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRH 356
            .|.|.          |...|.... ..:|.:.|.::::|.|::....:::|. .:|.|..::..|
Human   436 SAAFLLNDREEQKRRECGYSCSPL-NVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIH 499

  Fly   357 YFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGY 420
            ||  |||:| |:::.:|.||.......:..::|.    .:::..||||:.|:....||   .:.|
Human   500 YF--KGWFLIDMVAAIPFDLLIFGSGSDETTTLI----GLLKTARLLRLVRVARKLDR---YSEY 555

  Fly   421 PNAFRICKVVLAILVLI-HWNACMYFAI-SYEIGFSSD--SWVYNLN---GTRNN--------TL 470
            ..|  :..:::.|..|| ||.||:::|| :.|..:.:|  .|:.:|.   |.|.|        ::
Human   556 GAA--VLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSI 618

  Fly   471 QRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534
            :.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......
Human   619 KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 683

  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599
            :..:|..||:::.|.::.:.|..|:..:|.:.|:.:..:|...||...|:.|:|:|.:.::...|
Human   684 YHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 748

  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664
            :..:.|.....|.|.||.:|.|.....|||.:...|||...:|.:.||.:.::.||  .|:|.||
Human   749 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDD--IVVAILG 811

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729
            ...:|||:..|.....::    .|:||:|.|.||..:.:.||.|.|..|||
Human   812 KNDIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE-------------- 858

  Fly   730 KDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQA---------KIKQRL 785
                     |:|.         .:..|||:   .|:|.....|:...||:         |:::|.
Human   859 ---------FSDH---------FLTNLELT---FNLRHESAKADLLRSQSMNDSEGDNCKLRRRK 902

  Fly   786 AKLEMNGGPGTWRLECE-----PQSRARSGRLYSLQPKRR----PRSRPDATAKSSD 833
            ...|..|       |.|     |:..|.:.|.|  |..:|    .:||..:...|.|
Human   903 LSFESEG-------EKENSTNDPEDSADTIRHY--QSSKRHFEEKKSRSSSFISSID 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	61/237 (26%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	41/123 (33%)
		CAP_ED	604..717	CDD:237999	40/112 (36%)
		CLZ	720..791	CDD:293134	13/79 (16%)
KCNH7	XP_011510411.1	PAS_9	29..134	CDD:290162
		PAS	41..130	CDD:238075
		Ion_trans	456..679	CDD:278921	60/234 (26%)
		Ion_trans_2	<622..676	CDD:285168	16/53 (30%)
		Crp	747..>884	CDD:223736	49/177 (28%)
		CAP_ED	753..864	CDD:237999	42/148 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840