Protein Alignment CngA and Cnga1

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_445949.2
• Gene: Cnga1 / 85259
• RGDID: 621815
• Length: 683
• Species: Rattus norvegicus
• Alignment Length: 671
• Identity: 308/671 - (45%)
• Similarity: 418/671 - (62%)
• Gaps: 51/671 - (7%)

  Fly   127 IHRQPGGGAEQDEDEEEDDDDVDEDDDDEFGASVCEDNPEEAIARAD----HDTQQKQHYQPNAS 187
            |.|...|......|  .|:..:.|:.::           |:::.|::    ....|::||.|...
  Rat    27 IRRMENGACSSFSD--NDNGSLSEESEN-----------EDSLFRSNSYRRRGPSQREHYLPGTM 78

  Fly   188 DSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCP 252
            ....|.|.....|:|.::.|....:::     :...|:...|.|:   :|.......:|..:..|
  Rat    79 ALFNVNNSSNKDQDPKEKKKKKKEKKS-----KADDKKESKKDPE---KKKKKEKEKEKKKEEKP 135

  Fly   253 AMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFW 317
            ..:......|:         :.:||:...:|.||..::|.|:||...::.||.|.|:......:|
  Rat   136 KEKKEEEKKEV---------VVIDPSGNMYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYW 191

  Fly   318 YTLDYLCDFIYLLDTLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYI---W 379
            ...||:.|.:||.|..|....|:|:|||||:|..:|...|.....:.|||||::||||.|.   |
  Rat   192 LIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDKLKLIEKYKANLQFKLDVLSVIPTDLLYFKFGW 256

  Fly   380 WPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMY 444
            ..||            :||||||||:|::|:|.||||.|.|||.|||..:|:.|:::||||||:|
  Rat   257 NYPE------------IRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVY 309

  Fly   445 FAISYEIGFSSDSWVY-NLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFL 508
            ::||..|||.:|:||| ::|......|.|:|:||.||||||||||||||.|..|.||:|||.|||
  Rat   310 YSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYVFVVVDFL 374

  Fly   509 AGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGAL 573
            .||||||||||||||||||||.||.|||:|:|.:||||.||.|..::|.|||:||.|.|:....:
  Rat   375 IGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTV 439

  Fly   574 DEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVG 638
            ||..||..|||||:|||||.||:||||:||||.|.|.|||..|||||:.||:|||||||:|||:|
  Rat   440 DEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIG 504

  Fly   639 KEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAK 703
            :||||:|.|||:||.|||||....|..||.|||:|:|.|.|::.|||||||::|:||||||||:|
  Rat   505 REMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSK 569

  Fly   704 RDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLA 768
            .||.|.|::||:|::.|.::|.|:|.||||||..| |:.......:|..:.::|.||:.|..|.|
  Rat   570 DDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINI-ANLGSDPKDLEEKVTRMEGSVDLLQTRFA 633

  Fly   769 RLLAEYTASQAKIKQRLAKLE 789
            |:||||.:.|.|:||||.|:|
  Rat   634 RILAEYESMQQKLKQRLTKVE 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	130/250 (52%)
		CAP_ED	604..717	CDD:237999	73/112 (65%)
		CLZ	720..790	CDD:465160	32/70 (46%)
Cnga1	NP_445949.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..144		20/130 (15%)
		Ion_trans	156..398	CDD:459842	132/253 (52%)
		Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:P29973	286..394		70/107 (65%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P29973	353..356		2/2 (100%)
		C-linker. /evidence=ECO:0000250|UniProtKB:P29973	396..472		45/75 (60%)
		CAP_ED	470..586	CDD:237999	74/115 (64%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:P29973	476..596		74/119 (62%)
		CLZ	586..655	CDD:465160	32/70 (46%)