DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and Cnga4

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_445948.2	Gene:	Cnga4 / 85258	RGDID:	619844	Length:	575	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	243/516 - (47%)
Similarity:	343/516 - (66%)	Gaps:	10/516 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEG 339
            :||:...:|.||..:...::||:|.||.||.|.::..|....|:.|||..|.:||||..|..|.|
  Rat    27 LDPSGDYYYWWLNTMVFPIMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLLYLLDIGVRFHTG 91

  Fly   340 FLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRI 404
            ||:||:||.|...:...|..|..:.||:.|::|||.||:...|      ::|   .:||||.||:
  Rat    92 FLEQGILVVDKGMIASRYVRTWSFLLDLASLVPTDAAYVQLGP------HIP---TLRLNRFLRV 147

  Fly   405 NRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRN-N 468
            .||:|.||||||.|.|||||||.|::|.|.|:||||:|:|||:|..:||..|:|||....... .
  Rat   148 PRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFE 212

  Fly   469 TLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARV 533
            .|:|||:||||:|||.|||:|:||.|:.:.||||:|.|||..|:.||||:|::.|:|.|||.|..
  Rat   213 RLRRQYLYSFYFSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADA 277

  Fly   534 EFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDT 598
            .|......||:||..:.|...||.|||.|:.:........:|..:|..||::|:||:|:.||:.|
  Rat   278 AFYPDHALVKKYMKLQHVNKRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLST 342

  Fly   599 LKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATL 663
            |.:|:||.:.|..|||.|||||:.|.:|||:|:|||||:|:||||::.|:|:||.|||:|..|.|
  Rat   343 LSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVL 407

  Fly   664 GAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLL 728
            |||..|||:|::.|.||.:|||||||::||||||||||:|.||.|.||:||:|::.:.::|.::|
  Rat   408 GAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREIL 472

  Fly   729 RKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLE 789
            .|...||....|....:.::.|..::.|:..:::|..:.||||||..:|..||..|:.:||
  Rat   473 LKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAELESSALKIAYRIERLE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	109/220 (50%)
		Ion_trans_2	<477..527	CDD:285168	29/49 (59%)
		Crp	598..>722	CDD:223736	75/123 (61%)
		CAP_ED	604..717	CDD:237999	71/112 (63%)
		CLZ	720..791	CDD:293134	21/70 (30%)
Cnga4	NP_445948.2	Ion_trans	58..273	CDD:278921	110/223 (49%)
		P-loop_NTPase	116..>174	CDD:304359	34/66 (52%)
		IQ-type. /evidence=ECO:0000250	292..302		3/9 (33%)
		Crp	342..>519	CDD:223736	90/176 (51%)
		CAP_ED	348..464	CDD:237999	72/115 (63%)
		CLZ	464..535	CDD:293134	21/70 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338698
Domainoid	1	1.000	270	1.000	Domainoid score	I1752
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	1	1.000	-	-		otm45723
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750