Protein Alignment CngA and Cnga3

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_001385615.1
• Gene: Cnga3 / 85257
• RGDID: 70948
• Length: 670
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 330/691 - (47%)
• Similarity: 433/691 - (62%)
• Gaps: 70/691 - (10%)

  Fly   172 ADHDTQQKQH-----YQPNASDSSYVENGRKLIQEPSK----------RSKPSALRRTLQALRQR 221
            ||.|..|.::     :.|....||.|..|  ::.|..:          ...|:.:.|.:.::|..
  Rat    22 ADRDLDQVENGLGRSHSPCEETSSTVHQG--IVMETGELAGAAQSLFTSQGPARVSRFIISIRAW 84

  Fly   222 LTK--RNRPKPPDWFLEKF-----SNTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTL 279
            ..:  .:....||.||::|     ...::.::..:..|..::.....:.|..    :.:.|||:.
  Rat    85 AARHLHHEDPTPDSFLDRFHGAELKEVSSQERNAQPNPGGQEPPEGGKGRKK----DPIVVDPSS 145

  Fly   280 QSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQG 344
            ..:||||..::|.|.||...:|.||.|.|:.......|..|||..|.:|::|.||....|||:||
  Rat   146 NIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADALYVVDMLVRARTGFLEQG 210

  Fly   345 LLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWE 409
            |:|||..||.:||..|..:.||:||::||||||:        .|.:..|.: |.|||||.:||:|
  Rat   211 LMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYL--------KLGMNYPEL-RFNRLLRFSRLFE 266

  Fly   410 WFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-NLNGTRNNTLQRQ 473
            :||||||.|.|||.|||..:||..|::||||||:|||||..|||.:||||| |.:......|.|:
  Rat   267 FFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRK 331

  Fly   474 YIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNR 538
            ||||.||||||||||||||.|..|.||||||.|||.|||||||||||:||||||||.:|.|||.:
  Rat   332 YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 396

  Fly   539 MDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVR 603
            :|.:||||.||:|..:||.||||||.|.|:....:||:.||..|||||||||||.||:||||:||
  Rat   397 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVR 461

  Fly   604 IFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSV 668
            ||.|.|.|||..|||||:..|||||||||:|||:|:||||:|.|||:||.|||:|....|..||.
  Rat   462 IFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSY 526

  Fly   669 FGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGL 733
            |||:|:|.|.|:::|||||||:||:||||||||:|.||.|||::||:|:..|.::|.|:|.||.|
  Rat   527 FGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEYPDAKRALEEKGRQILMKDNL 591

  Fly   734 LDEQIF---ADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPG 795
            :|:.:.   ||::    :||..:|.||.|::.|..|.|||||||:|||.|:||||::||
  Rat   592 IDDDLVTARADAR----NIEEKVEYLESSLDGLQTRFARLLAEYSASQMKLKQRLSQLE------ 646

  Fly   796 TWRLECEPQSRARSGRLYSLQPKRRPRSRPDATAKSSDAAK 836
                    ....|.|..:|          || ...|.||:|
  Rat   647 --------SQMTRRGHGFS----------PD-RENSEDASK 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	141/247 (57%)
		CAP_ED	604..717	CDD:237999	74/112 (66%)
		CLZ	720..790	CDD:465160	34/72 (47%)
Cnga3	NP_001385615.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..138		2/30 (7%)
		Ion_trans	148..390	CDD:459842	143/250 (57%)
		Ion conduction pathway. /evidence=ECO:0000250|UniProtKB:P29973	278..386		75/107 (70%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P29973	345..348		2/2 (100%)
		C-linker. /evidence=ECO:0000250|UniProtKB:P29973	388..464		46/75 (61%)
		CAP_ED	462..578	CDD:237999	75/115 (65%)
		Cyclic nucleotide-binding domain. /evidence=ECO:0000250|UniProtKB:P29973	468..588		75/119 (63%)
		CLZ	578..647	CDD:465160	35/86 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..670		11/50 (22%)