DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and KAT1

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_199436.1	Gene:	KAT1 / 834666	AraportID:	AT5G46240	Length:	677	Species:	Arabidopsis thaliana

Alignment Length:	659	Identity:	138/659 - (20%)
Similarity:	252/659 - (38%)	Gaps:	126/659 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 FLEKFS-NTTNTDKIGKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSH--------YR-WLAI 288
            |.|:|. ...|.|.|      .:.:.||:::..|  |..|::....|:.|        || |...
plant     9 FFERFCVEEYNIDTI------KQSSFLSADLLPS--LGARINQSTKLRKHIISPFNPRYRAWEMW 65

  Fly   289 VSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQGLLVRDAFRL 353
            :.|.|:|:.         |    ..|..:..:.|..|.|:::|.:|:   ||....:::.
plant    66 LVLLVIYSA---------W----ICPFQFAFITYKKDAIFIIDNIVN---GFFAIDIILT----- 109

  Fly   354 RRHYFHTKGWYLDVLSMLPTD------LAYI--WWPPETCSSL-YLPCPVIVRLN------RLLR 403
               :|..   |||..|.|..|      :.|:  |:..:.||:. :.|..::...|      |:|.
plant   110 ---FFVA---YLDSHSYLLVDSPKKIAIRYLSTWFAFDVCSTAPFQPLSLLFNYNGSELGFRILS 168

  Fly   404 INRLW------EWFDRTETATGYPNAF--RICKVVLAILVLIHWNACMYFAISYEIGFSSDSW-- 458
            :.|||      ..|.|.|....: |.|  |..|::...|..||...|..:.|:........:|
plant   169 MLRLWRLRRVSSLFARLEKDIRF-NYFWIRCTKLISVTLFAIHCAGCFNYLIADRYPNPRKTWIG 232

  Fly   459 -VYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETP-TPENDVEYLFVVADFLAGVLIFATIVGNI 521
             ||  ...:..:|..:|:.:.|||..||||.|... ..||..|.||.:...:..:.:.|.::||:
plant   233 AVY--PNFKEASLWNRYVTALYWSITTLTTTGYGDFHAENPREMLFDIFFMMFNLGLTAYLIGNM 295

  Fly   522 GSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKL 586
            .:::.:.......|::.:....::.:..::.|:::.:::......:...| |.::..|..||..:
plant   296 TNLVVHWTSRTRTFRDSVRAASEFASRNQLPHDIQDQMLSHICLKFKTEG-LKQQETLNNLPKAI 359

  Fly   587 KAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLS- 650
            ::.||..:....:..:.:|.......|..||..:..:.|.|.:.|..:.:...::||:..|.:.
plant   360 RSSIANYLFFPIVHNIYLFQGVSRNFLFQLVSDIDAEYFPPKEDIILQNEAPTDLYILVSGAVDF 424

  Fly   651 ---VVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSD 712
               |.|.|.....|.:  |..||||.||..      ..:...||:...|.:..:::..|...:..
plant   425 TVYVDGHDQFQGKAVI--GETFGEVGVLYY------RPQPFTVRTTELSQILRISRTSLMSAMHA 481

  Fly   713 YPEARSTLTQRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLE------------------LS 759
            :.:....:.......||     .:|..|    :.||...|.|..:                  |.
plant   482 HADDGRVIMNNLFMKLR-----GQQSIA----IDDSNTSGHENRDFKSMGWEEWRDSRKDGYGLD 537

  Fly   760 VENLNMRLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRARSGRLYSLQPKRRPRSR 824
            |.|.....|.:.|.:......:|:.|.:.::.      |.:.|..|...:||.|:     ...|:
plant   538 VTNPTSDTALMDAIHKEDTEMVKKILKEQKIE------RAKVERSSSETAGRSYA-----NDSSK 591

  Fly   825 PDATAKSSD 833
            .|....||:
plant   592 KDPYCSSSN 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	59/246 (24%)
		Ion_trans_2	<477..527	CDD:285168	16/50 (32%)
		Crp	598..>722	CDD:223736	25/127 (20%)
		CAP_ED	604..717	CDD:237999	25/116 (22%)
		CLZ	720..791	CDD:293134	15/88 (17%)
KAT1	NP_199436.1	PLN03192	26..677	CDD:215625	132/636 (21%)
		Ion_trans_2	230..301	CDD:285168	21/72 (29%)
		CAP_ED	377..490	CDD:237999	25/120 (21%)
		KHA	611..674	CDD:288667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910