DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and DND1

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_197045.1	Gene:	DND1 / 831393	AraportID:	AT5G15410	Length:	726	Species:	Arabidopsis thaliana

Alignment Length:	568	Identity:	119/568 - (20%)
Similarity:	200/568 - (35%)	Gaps:	175/568 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 GCPAME----DAALSSEIR---GSSVL--------------CNRLS------VDPTLQSHYRWLA 287
            |.||..    |.|.:.|.|   |||::              ..||.      :||..:...||..
plant    62 GVPAFHSTSCDQAHAPEWRASAGSSLVPIQEGSVPNPARTRFRRLKGPFGEVLDPRSKRVQRWNR 126

  Fly   288 IVSLA--------VLYNIIFVVGRAVFWEINKSAPAFWY---------TLDYLC-DFIYLLDTLV 334
            .:.||        .|:.....:||.       :.||..|         |:...| |.::|....:
plant   127 ALLLARGMALAVDPLFFYALSIGRT-------TGPACLYMDGAFAAVVTVLRTCLDAVHLWHVWL 184

  Fly   335 HMHEGFLDQ-------GLLVRDAFRLRRHYFHT-KGWYLDVLSMLPTDLAYIWWPPETCSSLYLP 391
            .....::.:       |.||.|...:..||..: .|::.||:.:||...|..|          |.
plant   185 QFRLAYVSRESLVVGCGKLVWDPRAIASHYARSLTGFWFDVIVILPVPQAVFW----------LV 239

  Fly   392 CPVIVR------LNRLLRINRLWEWFD----------RTETATGYPNAFRICKVVLAILVLIHW- 439
            .|.::|      :..:|.:..|:::..          |.:..|||            |...|.|
plant   240 VPKLIREEKVKLIMTILLLIFLFQFLPKIYHCICLMRRMQKVTGY------------IFGTIWWG 292

  Fly   440 ---NACMYFAISYEIG---------------------------------------FSSDSWV-Y- 460
               |...||..|:..|                                       .|..|.| |
plant   293 FALNLIAYFIASHVAGGCWYVLAIQRVASCIRQQCMRTGNCNLSLACKEEVCYQFVSPTSTVGYP 357

  Fly   461 ----NLNGTRN-------------------------NTLQRQYIYSFYWSTLTLTTIGETPTP-E 495
                ||....|                         |:|..:.:|..:|..:||:|......| .
plant   358 CLSGNLTSVVNKPMCLDSNGPFRYGIYRWALPVISSNSLAVKILYPIFWGLMTLSTFANDLEPTS 422

  Fly   496 NDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVI 560
            |.:|.:|.:...|:|:|:|..::|||...:..:...:.:.|.|...::.:|..|::...|..||.
plant   423 NWLEVIFSIVMVLSGLLLFTLLIGNIQVFLHAVMAKKRKMQIRCRDMEWWMKRRQLPSRLRQRVR 487

  Fly   561 RWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVF 625
            |:....|:..|..||..::..||..|:.:|...:..|.:.:|.:|...:..:|:.:..:.|.:||
plant   488 RFERQRWNALGGEDELELIHDLPPGLRRDIKRYLCFDLINKVPLFRGMDDLILDNICDRAKPRVF 552

  Fly   626 SPGDYICRKGDVGKEMYIVKRGKLSVVG--DDGITVLATLGAGSVFGE 671
            |..:.|.|:||..:.|..:.||::..:.  ..|:...:||..|...|:
plant   553 SKDEKIIREGDPVQRMIFIMRGRVKRIQSLSKGVLATSTLEPGGYLGD 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	62/328 (19%)
		Ion_trans_2	<477..527	CDD:285168	15/50 (30%)
		Crp	598..>722	CDD:223736	19/76 (25%)
		CAP_ED	604..717	CDD:237999	18/70 (26%)
		CLZ	720..791	CDD:293134
DND1	NP_197045.1	PLN03192	<388..>600	CDD:215625	53/211 (25%)
DND1	NP_197045.1	CAP_ED	531..641	CDD:237999	18/70 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	53	1.000	Domainoid score	I4197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920