DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and CNGC18

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_196991.1	Gene:	CNGC18 / 831339	AraportID:	AT5G14870	Length:	706	Species:	Arabidopsis thaliana

Alignment Length:	549	Identity:	129/549 - (23%)
Similarity:	215/549 - (39%)	Gaps:	107/549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 AALSSEIRGS-----SVLCNRLSVDPTLQSHYRW---LAIVSLAVL-----YNIIFVVGRAVFWE 308
            |:.::..|||     |||.....:||.......|   ..|.|:..|     |..:..||......
plant    18 ASTAASNRGSDGSQFSVLWRHQILDPDSNIVTYWNHVFLITSILALFLDPFYFYVPYVGGPACLS 82

  Fly   309 INKSAPA---FWYTLDYLCDFIYLLDTLVHMHEGFL-------DQGLLVRDAFRLRRHYFHTKGW 363
            |:.|..|   |:.|   :.|..:||...:.....|:       .:|.||.|:..:...|..| .:
plant    83 IDISLAATVTFFRT---VADIFHLLHIFMKFRTAFVARSSRVFGRGELVMDSREIAMRYLKT-DF 143

  Fly   364 YLDVLSMLPTDLAYIWW--PPETCSSL--------------YLPCPVIV---------------- 396
            .:||.:|||.....||.  |..|..:.              |:|...|:
plant   144 LIDVAAMLPLPQLVIWLVIPAATNGTANHANSTLALIVLVQYIPRSFIIFPLNQRIIKTTGFIAK 208

  Fly   397 ------RLNRLLRI------NRLW------EWFDRTETATGYPNAFRICKVVLAIL--------- 434
                  ..|.||.|      ..:|      ..|..........||.|:...:.:.|
plant   209 TAWAGAAYNLLLYILASHVLGAMWYLSSIGRQFSCWSNVCKKDNALRVLDCLPSFLDCKSLEQPE 273

  Fly   435 ---------VLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGE 490
                     ||.|.:|.. ...:::.|..::::...:..|   ....:|:|..:|....|::.|:
plant   274 RQYWQNVTQVLSHCDATS-STTNFKFGMFAEAFTTQVATT---DFVSKYLYCLWWGLRNLSSYGQ 334

  Fly   491 TPTPENDV-EYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHE 554
            ..|....: |.||.:...:.|:::|..::||:.|.:.:|:|...|::.:....:::|..|::..|
plant   335 NITTSVYLGETLFCITICIFGLILFTLLIGNMQSSLQSMSVRVEEWRVKRRDTEEWMRHRQLPPE 399

  Fly   555 LEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLK 619
            |:.||.|:..|.|..:..:|||.:|.:||..|:.||...:.:..:::|..|...:..||:|:...
plant   400 LQERVRRFVQYKWLATRGVDEESILHSLPTDLRREIQRHLCLSLVRRVPFFSQMDDQLLDAICGC 464

  Fly   620 LKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVV----GDDGITVLATLGAGSVFG-EVSVLEIAG 679
            |...:.:.|.||.|:||...||..|.||::...    |..|.....||..|...| |:....:..
plant   465 LVSSLSTAGTYIFREGDPVNEMLFVIRGQIESSTTNGGRSGFFNSTTLRPGDFCGEELLTWALMP 529

  Fly   680 NRTGN--RRTANVRSLGYSDLFCLAKRDL 706
            |.|.|  ..|.:||:|...:.|.|:..||
plant   530 NSTLNLPSSTRSVRALSEVEAFALSAEDL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	57/298 (19%)
		Ion_trans_2	<477..527	CDD:285168	12/50 (24%)
		Crp	598..>722	CDD:223736	35/116 (30%)
		CAP_ED	604..717	CDD:237999	34/110 (31%)
		CLZ	720..791	CDD:293134
CNGC18	NP_196991.1	Ion_trans	92..378	CDD:278921	56/293 (19%)
		Crp	443..>579	CDD:223736	35/116 (30%)
		CAP_ED	449..580	CDD:237999	34/110 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	53	1.000	Domainoid score	I4197
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920