DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and KT2/3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_567651.1	Gene:	KT2/3 / 828311	AraportID:	AT4G22200	Length:	802	Species:	Arabidopsis thaliana

Alignment Length:	574	Identity:	127/574 - (22%)
Similarity:	243/574 - (42%)	Gaps:	63/574 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 GKGCPAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYR---------------WLAIVSLAVLYNI 297
            |||.....||:..|....|.::...|.|....|:|.|               |...:.|.|.|:.
plant    26 GKGREEEYDASSLSLNNLSKLILPPLGVASYNQNHIRSSGWIISPMDSRYRCWEFYMVLLVAYSA 90

  Fly   298 IFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ--GLLVRDAFRLRRHYFHT 360
            ........|  :|.|........|.:.|..:.:|.::.....::|:  .||||:..::...|..|
plant    91 WVYPFEVAF--LNSSPKRNLCIADNIVDLFFAVDIVLTFFVAYIDERTQLLVREPKQIAVRYLST 153

  Fly   361 KGWYL-DVLSMLPTD-LAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYP-- 421
              |:| ||.|.:|.| :.|:   ....|:|.:.|. ::.|.|..|:.|:...|.|.|....|.
plant   154 --WFLMDVASTIPFDAIGYL---ITGTSTLNITCN-LLGLLRFWRLRRVKHLFTRLEKDIRYSYF 212

  Fly   422 --NAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLT 484
              ..||:..|.   |.|:|...|.|:.|:........:|...:......:|..:||.:.|||..|
plant   213 WIRCFRLLSVT---LFLVHCAGCSYYLIADRYPHQGKTWTDAIPNFTETSLSIRYIAAIYWSITT 274

  Fly   485 LTTIGETPT-PENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAF 548
            :||:|.... ..|.:|.:|:....|..:.:.|.::||:.:::.......:||:|.::....::..
plant   275 MTTVGYGDLHASNTIEMVFITVYMLFNLGLTAYLIGNMTNLVVEGTRRTMEFRNSIEAASNFVNR 339

  Fly   549 RRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLL 613
            .|:...|:.:::.:....: ::.:|:::.::..||..:...|...:.:.::::|.:|......:|
plant   340 NRLPPRLKDQILAYMCLRF-KAESLNQQHLIDQLPKSIYKSICQHLFLPSVEKVYLFKGVSREIL 403

  Fly   614 EALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGD--DGITVLATLGAGSVFGEVSVLE 676
            ..||.|:|.:...|.:.:..:.:...::||:..|::.::..  :..:||.||..|.:||||..|.
plant   404 LLLVSKMKAEYIPPREDVIMQNEAPDDVYIIVSGEVEIIDSEMERESVLGTLRCGDIFGEVGALC 468

  Fly   677 IAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDGLLDEQIFAD 741
            .    .....|...:||  |.|..|....|.||:               |:.::|.....:.|..
plant   469 C----RPQSYTFQTKSL--SQLLRLKTSFLIETM---------------QIKQQDNATMLKNFLQ 512

  Fly   742 SQRVHDSIEGGIEKLELSVENLNM----RLARLLAEYTASQAKIKQRLAKLEMN 791
            ..:...:::.|..|.:.:.||.::    ..:.|:|..|...|.:...|.|.:::
plant   513 HHKKLSNLDIGDLKAQQNGENTDVVPPNIASNLIAVVTTGNAALLDELLKAKLS 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	58/228 (25%)
		Ion_trans_2	<477..527	CDD:285168	14/50 (28%)
		Crp	598..>722	CDD:223736	30/125 (24%)
		CAP_ED	604..717	CDD:237999	29/114 (25%)
		CLZ	720..791	CDD:293134	13/74 (18%)
KT2/3	NP_567651.1	PLN03192	23..802	CDD:215625	127/574 (22%)
		ANK repeat	574..604	CDD:293786
		ANK repeat	606..668	CDD:293786
		ANK repeat	670..695	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm987
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910