DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CngA and HCN3

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	NP_065948.1	Gene:	HCN3 / 57657	HGNCID:	19183	Length:	774	Species:	Homo sapiens

Alignment Length:	680	Identity:	170/680 - (25%)
Similarity:	291/680 - (42%)	Gaps:	128/680 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 PSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGS 266
            |..:|.|...||.|..|.|       |....:.|..|.:....:        :|...:.|  .|:
Human    36 PIPKSGPEPKRRHLGTLLQ-------PTVNKFSLRVFGSHKAVE--------IEQERVKS--AGA 83

  Fly   267 SVLCNRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLD 331
            .:      :.|.....:.|..|:.|.::.|:|.:.....|::...|.|  |...:.|.|..:|||
Human    84 WI------IHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP--WIVFNVLSDTFFLLD 140

  Fly   332 TLVHMHEGF-LDQG---LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAY--IWWPPETCSSLY 389
            .:::...|. :::|   ||...|.|.|  |..|  |:| |::|.:|.|..:  :...|...:.:|
Human   141 LVLNFRTGIVVEEGAEILLAPRAIRTR--YLRT--WFLVDLISSIPVDYIFLVVELEPRLDAEVY 201

  Fly   390 LPCPV--------IVRLNRLLRINRL------WE-----WFDRTETATGYPNAFRICKVVLAILV 435
            .....        |:.|.||||::||      ||     .:|......      ||..::..:|:
Human   202 KTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV------RIFNLIGMMLL 260

  Fly   436 LIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIG---ETPTPEND 497
            |.||:.|:.|.:.....|..|.|| ::|...|::..|||.::.:.:...:..||   :.|....|
Human   261 LCHWDGCLQFLVPMLQDFPPDCWV-SINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPD 324

  Fly   498 VEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRW 562
            |  ...:...:.|...:|..:|:..::|.:::.:|.::|.:...|:|||:|.::..:...|:..:
Human   325 V--WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEY 387

  Fly   563 FAYTWSQSGALDEERVLAALPDKLKAEI------AIQVHMDTLKQVRIFHDTEPGLLEALVLKLK 621
            :.:.: |....|||.:|..|.:.|:.||      .:..||.      :|...:|..:.|::.||:
Human   388 YEHRY-QGKMFDEESILGELSEPLREEIINFTCRGLVAHMP------LFAHADPSFVTAVLTKLR 445

  Fly   622 LQVFSPGDYICRKGDVGKEMYIVKRGKLSVVG----DDGITVLATLGAGSVFGEVSVLEIAGNRT 682
            .:||.|||.:.|:|.||::||.::.|.|||:.    |..:|      .||.|||:.:|      |
Human   446 FEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLT------DGSYFGEICLL------T 498

  Fly   683 GNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEAR----STLTQRGCQLLRKDGLLDEQIFADSQ 743
            ..||||:||:..|..|:.|:.......|.::|..|    :....|..::.:|:.:|..:....|
Human   499 RGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPS- 562

  Fly   744 RVHDSIEGGIEKLELSVENLNM-RLARLLAEYTASQAKIKQRLAKLEMNGGPGTWRLECEPQSRA 807
               ....|||.:..|...:.:| |..|..|..|.:|           ::|.|..|    ||...|
Human   563 ---PGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQ-----------LSGKPVLW----EPLVHA 609

  Fly   808 -------RSGRLYSLQPKRRPRS-RPDATA 829
                   .|....:|..:|.|.. .||:.|
Human   610 PLQAAAVTSNVAIALTHQRGPLPLSPDSPA 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	62/248 (25%)
		Ion_trans_2	<477..527	CDD:285168	9/52 (17%)
		Crp	598..>722	CDD:223736	41/131 (31%)
		CAP_ED	604..717	CDD:237999	40/116 (34%)
		CLZ	720..791	CDD:293134	14/71 (20%)
HCN3	NP_065948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		4/11 (36%)
		Involved in subunit assembly. /evidence=ECO:0000250	46..91		12/67 (18%)
		Ion_trans_N	49..91	CDD:285597	10/64 (16%)
		Ion_trans	111..358	CDD:278921	63/261 (24%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	354..774		87/324 (27%)
		Crp	422..>560	CDD:223736	46/155 (30%)
		CAP_ED	428..536	CDD:237999	41/119 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..774
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840