DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and cnga1b

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_701036.4	Gene:	cnga1b / 572249	ZFINID:	ZDB-GENE-110408-39	Length:	639	Species:	Danio rerio

Alignment Length:	653	Identity:	300/653 - (45%)
Similarity:	410/653 - (62%)	Gaps:	56/653 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 EEEDDDDVDEDDDDEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPSKR 205
            |:...:||.|:...:.||..  :|...:....:.|.::|:.           |...|..::..|.
Zfish    19 EQVTMEDVIENKRPDAGALF--NNTNNSNNNEEEDKKKKKK-----------EKKEKKEKKEKKE 70

  Fly   206 SKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSEIRGSSVLC 270
            .|....::..|..:::..::.:.|..:...||                 |......||.
Zfish    71 KKEKKEKKKEQEEKEKEKEKEKEKEKEKEKEK-----------------EKKEPLKEIE------ 112

  Fly   271 NRLSVDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVH 335
               .|||....:|.||.:::..|:||.||::.||.|.|:.......|:.||||.|.:||||.:..
Zfish   113 ---VVDPAGNMYYNWLFVITCPVMYNWIFIIARACFEELQGDYLILWFFLDYLSDAVYLLDMVFR 174

  Fly   336 MHEGFLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWP---PETCSSLYLPCPVIVR 397
            ...|:|:|||||:|..:||..|..:..:.||:.||:|||:.|:::.   ||            :|
Zfish   175 TRTGYLEQGLLVKDQKKLRDRYTDSLQFRLDLASMVPTDIFYLYFGMNYPE------------IR 227

  Fly   398 LNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-N 461
            :|:|||||||:|:|.||||.|.:||.|||..:|:.|:::||||||||::.|..|||.||::|| :
Zfish   228 MNKLLRINRLFEFFQRTETRTNFPNVFRISNLVMYIVIIIHWNACMYYSFSKAIGFGSDAFVYPD 292

  Fly   462 LNGTRNNTLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMIS 526
            .:......|.|:|.||.||||||||||||||.|..:.||.|||.|||.|||||||||||:||||:
Zfish   293 PSDPEFGRLVRKYAYSMYWSTLTLTTIGETPPPVENSEYFFVVTDFLVGVLIFATIVGNVGSMIT 357

  Fly   527 NMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIA 591
            |.|.||.:||.|:|.:||||:||:|..:||.|||:||.|.|:...|:||..||..|||||:||||
Zfish   358 NANAARADFQARIDAIKQYMSFRKVTKDLEKRVIKWFDYLWTNKKAVDEREVLKYLPDKLRAEIA 422

  Fly   592 IQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDG 656
            |.||:||||:||||.|.|.|||..|||||:.||:|||||||:|||:|:||||:|.|||:||.|||
Zfish   423 INVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDG 487

  Fly   657 ITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLT 721
            ||....|..||.|||:|:|.|.|:|.|||||||:||:||||||||:|.||.|.|::||:|::.|.
Zfish   488 ITQFVVLSDGSYFGEISILNIKGSRAGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKAMLE 552

  Fly   722 QRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLA 786
            ::|.|:|.||.|||.::........| :|..::|:...:|:|..|.||||||..|:|.|:|:|:.
Zfish   553 EKGRQILMKDNLLDLELAKQGPDPKD-MEEKVQKIGGVLEDLQTRFARLLAEQEAAQGKLKKRVT 616

  Fly   787 KLE 789
            |||
Zfish   617 KLE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	114/223 (51%)
		Ion_trans_2	<477..527	CDD:285168	39/49 (80%)
		Crp	598..>722	CDD:223736	82/123 (67%)
		CAP_ED	604..717	CDD:237999	75/112 (67%)
		CLZ	720..791	CDD:293134	29/70 (41%)
cnga1b	XP_701036.4	Ion_trans	151..363	CDD:278921	115/223 (52%)
		Crp	429..629	CDD:223736	110/192 (57%)
		CAP_ED	435..551	CDD:237999	76/115 (66%)
		CLZ	551..621	CDD:293134	29/70 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578299
Domainoid	1	1.000	289	1.000	Domainoid score	I1516
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I925
OMA	1	1.010	-	-		QHG48384
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	1	1.000	-	-		otm25512
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X511
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770