DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CngA and cnga4

DIOPT Version :9

Sequence 1:	NP_001188960.1	Gene:	CngA / 36806	FlyBaseID:	FBgn0261612	Length:	840	Species:	Drosophila melanogaster
Sequence 2:	XP_002663442.3	Gene:	cnga4 / 568123	ZFINID:	ZDB-GENE-070912-292	Length:	648	Species:	Danio rerio

Alignment Length:	517	Identity:	240/517 - (46%)
Similarity:	345/517 - (66%)	Gaps:	12/517 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 VDPTLQSHYRWLAIVSLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEG 339
            :||:.:.:|.||.|::|.:.||.:.::.|..|:.|.::..|.|.|||||||.:|:|||::....|
Zfish    46 IDPSEEFYYTWLQIMTLPICYNWVIIICRTCFYTIEEAYVATWLTLDYLCDLVYVLDTIIGFRTG 110

  Fly   340 FLDQGLLVRDAFRLRRHYFHTKGWYLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRI 404
            ||:||:||||..||:..|..:..:..|:.|:|||||.|:        .|.:..| :||:||.||.
Zfish   111 FLEQGILVRDLSRLKTRYLRSSRFKWDMTSLLPTDLLYL--------QLGIHTP-LVRVNRFLRT 166

  Fly   405 NRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMYFAISYEIGFSSDSWVY-NLNGTRNN 468
            .||.|..||.||.|.:|||||:.|::|.|.||||||||:||::|..|||.:|.||| |::.....
Zfish   167 GRLNEALDRMETRTSFPNAFRVAKLMLYIFVLIHWNACIYFSLSNYIGFGADPWVYPNISHPEFA 231

  Fly   469 TLQRQYIYSFYWSTLTLTTIGETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARV 533
            :::|||.|.|::|||.|||:|:|||||.:.||:|::||.|..||:||::||::|.:||::.....
Zfish   232 SMRRQYFYCFWFSTLILTTVGDTPTPEREEEYMFLIADMLIAVLVFASVVGSMGDVISSLRDRDN 296

  Fly   534 EFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDT 598
            .|....:.||.|:...|:..||:.||..|:.:.........|..:|..||..|:...|:.||:.|
Zfish   297 VFFPDHELVKGYLRSHRISKELQKRVNDWYQHLHINKKITRENEILQHLPMTLQTATAVSVHLPT 361

  Fly   599 LKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATL 663
            |.:|.||.:.|..|||.|||||..||:|||:|:|:|||||.||||:|.|||:||.|||:|..|.|
Zfish   362 LSKVTIFQNCENSLLEQLVLKLTPQVYSPGEYVCKKGDVGHEMYIIKEGKLAVVADDGVTQFAVL 426

  Fly   664 GAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLL 728
            |.|:.|||:|:|.|.||::|||||||:||:||||||.|:|.||.|||.:||.|:..|.::|.|:|
Zfish   427 GDGNFFGEISILNIKGNKSGNRRTANIRSIGYSDLFSLSKEDLTETLLEYPAAKRLLEEKGRQIL 491

  Fly   729 RKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQAKIKQRLAKLEM 790
            .|.|:|:|.:..:.:  .:..|..:.:||..:|.|..:||||:||..:|..|:.||:.:||:
Zfish   492 TKMGMLEEAVEGEGE--VEKTEDKVNRLEGILEMLQTKLARLIAELESSARKMMQRVDQLEL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	309..529	CDD:278921	109/220 (50%)
		Ion_trans_2	<477..527	CDD:285168	27/49 (55%)
		Crp	598..>722	CDD:223736	78/123 (63%)
		CAP_ED	604..717	CDD:237999	73/112 (65%)
		CLZ	720..791	CDD:293134	25/71 (35%)
cnga4	XP_002663442.3	Ion_trans	77..294	CDD:278921	110/225 (49%)
		Crp	361..>497	CDD:223736	83/135 (61%)
		CAP_ED	367..483	CDD:237999	74/115 (64%)
		CLZ	483..552	CDD:293134	25/71 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578271
Domainoid	1	1.000	139	1.000	Domainoid score	I4733
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100817
Panther	1	1.100	-	-	O	PTHR45638
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750